INT17559

Context Info Confidence 0.28 First Reported 1985 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 13 Total Number 13 Disease Relevance 4.47 Pain Relevance 2.37

transport (Scn7a)

Anatomy Link Frequency urine 2 neurons 1 Brain 1 Scn7a (Mus musculus)

Pain Link Frequency Relevance Heat Neurotransmitter 3 100.00 tetrodotoxin 9 99.48 agonist 27 99.24 antagonist 6 97.68 Calcium channel 5 90.80 Morphine 7 89.56 anesthesia 5 88.56 Action potential 178 88.36 Kinase C 2 85.08 ischemia 13 82.92

Disease Link Frequency Relevance Heat Infection 15 99.88 Pressure And Volume Under Development 50 99.32 Cerebral Edema 4 97.36 Giardiasis 10 97.28 Targeted Disruption 7 90.32 Toxicity 2 87.84 Alzheimer's Dementia 3 85.60 Cv Unclassified Under Development 10 82.92 Hypoxia 3 82.44 INFLAMMATION 15 79.48

Sentences Mentioned In

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Under basal conditions, intact tissues exhibited net Na+ absorption and net Cl- secretion, whereas mucosal tissues displayed greater net Na+ absorption and net Cl- absorption.

Localization (secretion) of Na

1) Confidence 0.28 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2724141 Disease Relevance 0 Pain Relevance 0.18

It has been suggested that ATPase might be the enzyme responsible for the observed pharmacological responses of the neurons to the application of the drug by affecting the Na+, K+ flux and neurotransmitter release.

Localization (release) of Na in neurons associated with neurotransmitter

2) Confidence 0.19 Published 1985 Journal J Hirnforsch Section Abstract Doc Link 3005393 Disease Relevance 0 Pain Relevance 0.84

Although the presence of Ca(2+)-ionophore in the medium resulted in a net secretion of Na+ and Cl- in controls, it could not cause any change in the fluxes of these ions in infected animals.

Localization (secretion) of Na

3) Confidence 0.13 Published 1991 Journal J Diarrhoeal Dis Res Section Abstract Doc Link 1918833 Disease Relevance 0.45 Pain Relevance 0.16

Net secretion of Na+ and Cl- was observed in infected animals, whereas in non-infected (control) animals there was net absorption of Na+ ions and marginal secretion of Cl- ions.

Localization (secretion) of Na

4) Confidence 0.13 Published 1991 Journal J Diarrhoeal Dis Res Section Abstract Doc Link 1918833 Disease Relevance 0.37 Pain Relevance 0.12

The addition of the neurotoxin, tetrodotoxin caused net absorption of Na+, Cl- and net secretion of Ca2+ in the control group, but it could not produce any effect on the fluxes of these ions in the infected group.

Localization (secretion) of Na associated with tetrodotoxin

5) Confidence 0.13 Published 1991 Journal J Diarrhoeal Dis Res Section Abstract Doc Link 1918833 Disease Relevance 0.49 Pain Relevance 0.19

These findings demonstrate that, in G. lamblia infection, the secretion of Na+ and Cl- is associated with an increase in absorption of Ca2+ and an increase in calmodulin activity in intestinal microvillar core.

Localization (secretion) of Na associated with infection

6) Confidence 0.13 Published 1991 Journal J Diarrhoeal Dis Res Section Abstract Doc Link 1918833 Disease Relevance 0.48 Pain Relevance 0.17

Net secretion of Na+ and Cl- was observed in infected animals, whereas in non-infected (control) animals there was net absorption of Na+ ions and marginal secretion of Cl- ions.

Localization (secretion) of Na

7) Confidence 0.13 Published 1991 Journal J Diarrhoeal Dis Res Section Abstract Doc Link 1918833 Disease Relevance 0.30 Pain Relevance 0.03

Urine osmolality and 24-hour excretion of fluid, Na+, K+ and albumin were not different between genotypes, but urine pH was more alkaline in PKC-beta-/- mice.

Localization (excretion) of Na in urine

8) Confidence 0.07 Published 2006 Journal Kidney Blood Press. Res. Section Abstract Doc Link 16582576 Disease Relevance 0.22 Pain Relevance 0.17

The RSBFI increased in response to the Na+ entry that occurred upon addition of monensin to cells in medium HS (Fig. 1B) and decreased when monensin promoted Na+ release into a Na+-deficient (NMDG-substituted) medium (Fig. 1C).

Localization (release) of Na

9) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2729922 Disease Relevance 0 Pain Relevance 0

The response to urine was completely eliminated when both extracellular Ca2+ and Na+ were removed (Fig. 4).

Localization (removed) of Na in urine

10) Confidence 0.05 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2806418 Disease Relevance 0 Pain Relevance 0.07

As K channels are predominantly closed, the net membrane and axial current variability must result from Na channel noise (cf. matching SD curves between ?

Localization (noise) of Na

11) Confidence 0.04 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.08

Brain edema is generally separated into two components, an initial osmotic swelling of cells (cytotoxic edema) that depletes the extracellular space of Na+, Cl?

Localization (space) of Na in Brain associated with pressure and volume under development and cerebral edema

12) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 1.45 Pain Relevance 0.08

release to the same extent as did the NA, suggesting that PPAR?

Localization (release) of NA

13) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2581793 Disease Relevance 0.70 Pain Relevance 0.28

General Comments

This test has worked.