INT17562

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Context Info
Confidence 0.51
First Reported 1983
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 16.91
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lipg) extracellular space (Lipg) extracellular region (Lipg)
molecular_function (Lipg)
Anatomy Link Frequency
soleus 3
blood 2
pancreas 2
plasma 1
myocardium 1
Lipg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 13 98.74 Very High Very High Very High
analgesia 6 98.64 Very High Very High Very High
qutenza 5 96.24 Very High Very High Very High
GABA receptor 1 94.88 High High
tolerance 38 93.92 High High
antagonist 14 93.60 High High
ischemia 8 93.28 High High
opioid receptor 2 93.16 High High
Bile 1 88.24 High High
alcohol 21 86.40 High High
Disease Link Frequency Relevance Heat
Hyperlipidemia 113 99.92 Very High Very High Very High
Pancreatitis 68 99.74 Very High Very High Very High
Diabetes Mellitus 245 99.64 Very High Very High Very High
Body Weight 69 99.36 Very High Very High Very High
Stress 28 99.16 Very High Very High Very High
Disorder Of Lipid Metabolism 117 99.04 Very High Very High Very High
Obesity 193 98.62 Very High Very High Very High
Fatty Liver 2 96.78 Very High Very High Very High
Death 44 95.36 Very High Very High Very High
Syndrome 5 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the hepatic activity of hepatic lipase was reduced by 29% after 60 min of hepatic dearterialization, a reduction which remained after 60 min of reperfusion.
Negative_regulation (reduced) of lipase
1) Confidence 0.51 Published 1991 Journal J. Hepatol. Section Abstract Doc Link 1918876 Disease Relevance 0.08 Pain Relevance 0.08
Axotomy at P2 results in statistically significant (p < 0.05) motor unit loss in both EDL and soleus in all age groups.
Negative_regulation (loss) of EDL in soleus
2) Confidence 0.51 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC522819 Disease Relevance 0.27 Pain Relevance 0.03
A lipase inhibitor, varepsilon-polylysine, coinjected with corn oil completely suppressed the corn oil-induced changes in ASNA and GVNA.
Negative_regulation (inhibitor) of lipase
3) Confidence 0.50 Published 2010 Journal Neurosci. Res. Section Abstract Doc Link 20362017 Disease Relevance 0 Pain Relevance 0
Preliminary administration of membrane protectors, the antioxidant ionol and nicotinamid , a lipase inhibitor, prevents such post-stress disturbances to a considerable degree.
Negative_regulation (inhibitor) of lipase associated with stress
4) Confidence 0.47 Published 1984 Journal Kardiologiia Section Abstract Doc Link 6233446 Disease Relevance 0.65 Pain Relevance 0.15
In infarction, these above said stress-induced disturbances of the contractile function of nonischemic divisions of the heart were found to be prevented or limited by factors stabilizing the membranous lipid bilayer of cardiomyocytes, i.e., by antioxidant ionol, by nicotinamide, a lipase inhibitor, and by chloroquine, a phospholipase inhibitor.
Negative_regulation (inhibitor) of lipase in cardiomyocytes associated with stress and infarction
5) Confidence 0.46 Published 1983 Journal Clin Cardiol Section Abstract Doc Link 6682360 Disease Relevance 0.99 Pain Relevance 0.18
Ischemic preconditioning, applied prior to induction of pancreatitis, caused the reduction in plasma lipase, plasma interleukin-1beta and histological signs of pancreatic damage, as well as attenuated the reduction in pancreatic blood flow and DNA synthesis.
Negative_regulation (reduction) of plasma lipase in blood associated with pancreatitis
6) Confidence 0.43 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12892840 Disease Relevance 0.94 Pain Relevance 0.43
It is noticeable, however, that there is a marked reduction in muscle weight from P28 to adulthood both in the EDL and the soleus.
Negative_regulation (reduction) of EDL in soleus
7) Confidence 0.37 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC522819 Disease Relevance 0.65 Pain Relevance 0
This marked reduction of tension developing ability of both EDL and soleus, in adult rats, is established after the first month of life.
Negative_regulation (reduction) of EDL in soleus
8) Confidence 0.37 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC522819 Disease Relevance 0.17 Pain Relevance 0
RESULTS: EA significantly decreased the pancreatic weight/body weight ratio in CCK-induced acute pancreatitis, increased the pancreatic levels of HSP60 and HSP72, and decreased the beta-amylase and lipase levels associated with CCK-induced acute pancreatitis.
Negative_regulation (decreased) of lipase in body
9) Confidence 0.26 Published 2007 Journal Neuroimmunomodulation Section Body Doc Link 17804915 Disease Relevance 0.07 Pain Relevance 0
In the EDL, the total protein level of AKT was unaffected by a 24 h LPS infusion (Fig. 4A), although a trend (P?
Neg (unaffected) Negative_regulation (unaffected) of EDL
10) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0.04
This is in contrast to our previously published findings where declines in AKT Ser473 phosphorylation and total protein levels of AKT were reported in EDL following 24 h LPS treatment [3].
Negative_regulation (reported) of EDL
11) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
The protein-to-DNA ratio, a marker of protein content, was significantly reduced in the EDL following 24 h LPS administration (23%; P<0.05), but was no different from controls in the myocardium.
Negative_regulation (reduced) of EDL in myocardium
12) Confidence 0.20 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
1) intravenously for 2 h, 6 h or 24 h (saline administered control animals were also included), after which the extensor digitorum longus (EDL) and myocardium were removed under terminal anaesthesia.
Negative_regulation (removed) of EDL in EDL
13) Confidence 0.20 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
The findings as reported, would suggest that derangements in UP-mediated muscle protein degradation were predominantly responsible for the observed reductions in EDL protein content, although direct measures of muscle protein synthesis and muscle protein breakdown would have been useful in providing further support of this view.
Negative_regulation (reductions) of EDL protein in muscle
14) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
Other blood metabolites and pancreatic myeloperoxidase, amylase and lipase, were significantly decreased.
Negative_regulation (decreased) of lipase in blood
15) Confidence 0.17 Published 2003 Journal Pancreatology Section Body Doc Link 14631103 Disease Relevance 0 Pain Relevance 0
This was accompanied by the reduction of serum lipase, and TNFalpha activities.
Negative_regulation (reduction) of serum lipase
16) Confidence 0.16 Published 2009 Journal Growth Horm. IGF Res. Section Abstract Doc Link 19615927 Disease Relevance 0.82 Pain Relevance 0.20
Acute insulin deficiency initially causes an increase in free fatty acid mobilization from adipose tissue, resulting in increased secretion of VLDL-triglyceride from liver.[26] In diabetic rats, there is a decrease in lipoprotein lipase activity[27] resulting in impaired clearance of VLDL and chylomicrons from plasma.[28] In our study, treatment with ‘Glycoherb’ granules suspended in 1% CMC solution significantly decreased both serum cholesterol and triglyceride levels in diabetic rats.
Negative_regulation (decrease) of lipase in plasma associated with diabetes mellitus, obesity and disorder of lipid metabolism
17) Confidence 0.15 Published 2010 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2859276 Disease Relevance 1.38 Pain Relevance 0.03
Thereby, to improve obesity and hyperlipidemia, it may be effective to reduce fat absorption by lipase inhibition [28].
Negative_regulation (inhibition) of lipase in fat associated with obesity and hyperlipidemia
18) Confidence 0.12 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC3002919 Disease Relevance 0.57 Pain Relevance 0.03
Glucocorticoids have been reported to induce hyperlipidemia by inhibiting lipoproteins lipase and altering the level/action of hormone sensitive lipase [56,57] thus it disable the uptake of FFA by adipose tissue [58].
Negative_regulation (inhibiting) of lipase in adipose tissue associated with obesity and hyperlipidemia
19) Confidence 0.11 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.50 Pain Relevance 0
In children this can result from a deficiency of lipoprotein lipase (LPL) or its cofactor, apolipoprotein (apo) C-II.
Negative_regulation (deficiency) of lipase associated with disorder of lipid metabolism
20) Confidence 0.11 Published 2010 Journal Curr Diab Rep Section Body Doc Link PMC2890983 Disease Relevance 2.17 Pain Relevance 0.14

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