INT175626

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Context Info
Confidence 0.03
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.72
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TIMP1, MMP9) peptidase activity (MMP9) extracellular space (MMP9)
aging (TIMP1) proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9)
Anatomy Link Frequency
basement membrane 2
TIMP1 (Homo sapiens)
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 18 100.00 Very High Very High Very High
cytokine 5 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 33 96.88 Very High Very High Very High
Prostate Cancer 87 86.16 High High
Cancer 37 55.16 Quite High
Malignant Neoplastic Disease 6 49.04 Quite Low
Adhesions 28 48.64 Quite Low
Benign Prostatic Hypertrophy 4 41.84 Quite Low
Carcinoma 4 5.00 Very Low Very Low Very Low
Breast Cancer 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the main component of the basement membrane (BM) is collagen type IV, a substrate for both MMP-2 and MMP-9, it is conceivable that the higher expression of MMP-9 and MT1-MMP and the higher ratios of MMP-2 and MMP-9 to TIMP-1 play important roles in the destruction of the BM necessary for invasion and metastasis.
TIMP-1 Positive_regulation (ratios) of Gene_expression (expression) of MMP-9 in basement membrane associated with metalloproteinase and metastasis
1) Confidence 0.03 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 0.72 Pain Relevance 0.57

General Comments

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