INT175636

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Context Info
Confidence 0.30
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 11.38
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MMRN1) cell adhesion (MMRN1)
Anatomy Link Frequency
ECM 6
stroma 2
MMRN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 97 99.98 Very High Very High Very High
Pain 21 99.28 Very High Very High Very High
Osteoarthritis 65 95.72 Very High Very High Very High
Inflammation 61 91.36 High High
cytokine 62 89.52 High High
COX-2 inhibitor 6 75.04 Quite High
rheumatoid arthritis 16 35.28 Quite Low
imagery 27 5.00 Very Low Very Low Very Low
Central nervous system 21 5.00 Very Low Very Low Very Low
positron emission tomography 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 854 99.40 Very High Very High Very High
Pain 25 99.28 Very High Very High Very High
Metastasis 111 98.74 Very High Very High Very High
Pancreatic Cancer 93 98.20 Very High Very High Very High
Osteoarthritis 65 95.72 Very High Very High Very High
Adhesions 39 94.00 High High
INFLAMMATION 64 91.36 High High
Cold Sores 367 90.36 High High
Apoptosis 81 89.80 High High
Stomach Cancer 108 86.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This progress would rely on invadopodia which are membrane protrusions that localize enzymes required for ECM degradation, and MMP9 would be required in the initial steps of invadopodia formation [20].
Positive_regulation (required) of Protein_catabolism (degradation) of ECM
1) Confidence 0.30 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 1.70 Pain Relevance 0.07
High levels of proteases facilitate ECM degrading, thereby creating a path for the migration of cancer cells.
Positive_regulation (facilitate) of Protein_catabolism (degrading) of ECM associated with cancer
2) Confidence 0.22 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 1.64 Pain Relevance 0.08
Thus, we supposed that MMPs-mediated degradation of BM and ECM can act as both positive and negative regulators of tumor progression which resulted in the unexpected results predicted in the traditional view because of the change of the tumor stroma during the cancer progression.
Positive_regulation (mediated) of Protein_catabolism (degradation) of ECM in stroma associated with cancer and metalloproteinase
3) Confidence 0.20 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 1.06 Pain Relevance 0.18
Further more, the process of pericellular proteolysis leads to ECM degradation and realignment during cell movement and integrate it into established steps of cell migration [11].
Positive_regulation (leads) of Protein_catabolism (degradation) of ECM
4) Confidence 0.20 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 0.72 Pain Relevance 0.08
The cysteine protease cathepsin C and the aspartic protease cathepsin D have been implicated in ECM degradation, facilitating tumor growth, invasion and metastasis.
Positive_regulation (protease) of Protein_catabolism (degradation) of ECM in ECM associated with cancer and metastasis
5) Confidence 0.13 Published 2009 Journal Journal of Proteome Research Section Body Doc Link PMC2652408 Disease Relevance 0.84 Pain Relevance 0
The cysteine protease cathepsin C and the aspartic protease cathepsin D have been implicated in ECM degradation, facilitating tumor growth, invasion and metastasis.
Positive_regulation (protease) of Protein_catabolism (degradation) of ECM in ECM associated with cancer and metastasis
6) Confidence 0.13 Published 2009 Journal Journal of Proteome Research Section Body Doc Link PMC2652408 Disease Relevance 0.84 Pain Relevance 0
Plasmin is the main protease involved in (pro)-u-PA activation, which gives origin to the initiation of the classical protease cascade (plasmin, interstitial MMPs, MT1-MMP, Gelatinase A) leading to ECM degradation.
Positive_regulation (leading) of Protein_catabolism (degradation) of ECM associated with metalloproteinase
7) Confidence 0.09 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 0.15 Pain Relevance 0.05
An excessive increase in the uPA system was shown to associate with tumour progression and metastasis formation [29-31], and an increase in MMPs is associated with degradation of ECM leading to the release of growth factors like bFGF and VEGF.
Positive_regulation (leading) of Protein_catabolism (degradation) of ECM associated with cancer and metastasis
8) Confidence 0.06 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2841144 Disease Relevance 1.05 Pain Relevance 0.04
Recent studies revealed that senescent cells from preneoplasic tissues also promoted ECM degradation via the secretion of metalloproteinases such as MMP-3 [52].
Positive_regulation (promoted) of Protein_catabolism (degradation) of ECM associated with metalloproteinase
9) Confidence 0.05 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2845788 Disease Relevance 1.22 Pain Relevance 0.37
However, some concerns about strategies that cause degradation of ECM exist.
Positive_regulation (cause) of Protein_catabolism (degradation) of ECM
10) Confidence 0.05 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.20 Pain Relevance 0.04
B activates the expression of matrix degrading enzymes such as matrix metalloproteinases (MMPs) and enzymes responsible for production of prostaglandins (that is, cyclooxygenase-2 (COX-2)) leading to enhanced degradation of the ECM and induction of pain [8].
Positive_regulation (enhanced) of Protein_catabolism (degradation) of ECM in ECM associated with pain and metalloproteinase
11) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.97 Pain Relevance 0.48

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