INT17564

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Context Info
Confidence 0.75
First Reported 1980
Last Reported 2011
Negated 5
Speculated 16
Reported most in Body
Documents 322
Total Number 338
Disease Relevance 208.51
Pain Relevance 60.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cytoplasm (Gpt)
Anatomy Link Frequency
liver 61
plasma 26
blood 10
lung 5
upper 5
Gpt (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 1508 100.00 Very High Very High Very High
Nicotine 240 99.68 Very High Very High Very High
Fibrositis 21 99.56 Very High Very High Very High
methotrexate 18 99.46 Very High Very High Very High
Morphine 10 99.04 Very High Very High Very High
chemokine 411 99.02 Very High Very High Very High
psoriasis 93 98.92 Very High Very High Very High
Infliximab 115 98.84 Very High Very High Very High
cytokine 976 98.82 Very High Very High Very High
Inflammation 1039 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 799 100.00 Very High Very High Very High
Hepatotoxicity 676 100.00 Very High Very High Very High
Necrosis 399 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 337 100.00 Very High Very High Very High
Targeted Disruption 171 100.00 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 145 99.98 Very High Very High Very High
Metabolic Syndrome 138 99.96 Very High Very High Very High
Hepatocellular Cancer 1318 99.92 Very High Very High Very High
Fatty Liver 320 99.90 Very High Very High Very High
Dengue 850 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant elevation (p<0.001) of the levels of AST and ALT was observed in mice toxicated with APAP.
Gene_expression (levels) of ALT associated with paracetamol
1) Confidence 0.75 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19109935 Disease Relevance 0.68 Pain Relevance 0.70
On the other hand, APAP induced increases in plasma AST and ALT levels in the highest dose group only, and the DNA damage in the liver increased at the same dose.
Gene_expression (levels) of ALT in plasma associated with paracetamol
2) Confidence 0.72 Published 2008 Journal J Toxicol Sci Section Abstract Doc Link 19043273 Disease Relevance 0.09 Pain Relevance 0.38
Three and six hours after intraperitoneal injection of TBE, intramuscular injection of ketamine/xylazine combination (K/X), intraperitoneal injection of pentobarbital (PB), and inhalation of isoflurane (IF), or intraperitoneal and intramuscular injection of control saline, mice were exsanguinated and serum was obtained for measurement of hepatic aspartate transaminase (AST), alanine transaminase (ALT) and gamma-glutamyltransferase (GGT).
Gene_expression (measurement) of ALT associated with ketamine and isoflurane
3) Confidence 0.67 Published 2002 Journal Comp. Med. Section Abstract Doc Link 11900415 Disease Relevance 0.17 Pain Relevance 0.30
Three and six hours after intraperitoneal injection of TBE, intramuscular injection of ketamine/xylazine combination (K/X), intraperitoneal injection of pentobarbital (PB), and inhalation of isoflurane (IF), or intraperitoneal and intramuscular injection of control saline, mice were exsanguinated and serum was obtained for measurement of hepatic aspartate transaminase (AST), alanine transaminase (ALT) and gamma-glutamyltransferase (GGT).
Gene_expression (measurement) of alanine transaminase associated with ketamine and isoflurane
4) Confidence 0.67 Published 2002 Journal Comp. Med. Section Abstract Doc Link 11900415 Disease Relevance 0.17 Pain Relevance 0.30
General observations of gpt delta transgenic mice administrated with particles
Gene_expression (transgenic mice) of gpt associated with targeted disruption
5) Confidence 0.66 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2745356 Disease Relevance 0.26 Pain Relevance 0
Treatment of fasted mice with 300 mg/kg AAP caused centrilobular necrosis with high plasma alanine aminotransferase (ALT) activities at 6 h (3280 +/- 570 U/l) but no evidence of LPO (hepatic malondialdehyde, 4-hydroxynonenal).
Gene_expression (necrosis) of ALT in plasma associated with necrosis
6) Confidence 0.66 Published 2003 Journal Toxicol. Sci. Section Abstract Doc Link 12944590 Disease Relevance 0.74 Pain Relevance 0.23
The patients were also required to meet the following criteria: age of 75 years or less, amenable to oral administration of drugs, a Karnofsky performance score of 60, a life expectancy of at least 3 months, and an adequate hematological status (defined as having a total leukocyte count greater than 3,500 per mm3, neutrophil count of greater than 1,500 per mm3, platelet count greater than 100,000 per mm3, serum creatinine levels under 1.5 mg/dl, total serum bilirubin under 1.5 mg/dl, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels less than 2 times the upper limit of the normal range).
Gene_expression (levels) of ALT in upper
7) Confidence 0.65 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883242 Disease Relevance 0.58 Pain Relevance 0
The patients were also required to meet the following criteria: age of 75 years or less, amenable to oral administration of drugs, a Karnofsky performance score of 60, a life expectancy of at least 3 months, and an adequate hematological status (defined as having a total leukocyte count greater than 3,500 per mm3, neutrophil count of greater than 1,500 per mm3, platelet count greater than 100,000 per mm3, serum creatinine levels under 1.5 mg/dl, total serum bilirubin under 1.5 mg/dl, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels less than 2 times the upper limit of the normal range).
Gene_expression (levels) of alanine aminotransferase in upper
8) Confidence 0.65 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883242 Disease Relevance 0.59 Pain Relevance 0
The extract had no significant effect on the increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin in CCl(4) treated animals (p > 0.05).
Gene_expression (levels) of ALT
9) Confidence 0.64 Published 2006 Journal Phytother Res Section Abstract Doc Link 16619345 Disease Relevance 0.17 Pain Relevance 0.65
Serum alanine transaminase (ALT) levels, liver histology, hepatic leukocyte accumulation, and cytokine/chemokine expression were assessed.
Gene_expression (expression) of Serum alanine transaminase in leukocyte
10) Confidence 0.64 Published 2004 Journal Gastroenterology Section Body Doc Link 15578514 Disease Relevance 0.09 Pain Relevance 0
With regard to hematology and blood chemistry results, nephrotoxic markers were not changed, but aspartate aminotransferase (AST) and alanine aminotransferase (ALT) increased in the 150 mg/kg-treated group, and bone marrow counts (BMC) decreased in all of the treatment groups 24 hr after treatment.
Gene_expression (increased) of ALT in blood
11) Confidence 0.63 Published 2008 Journal J Toxicol Sci Section Abstract Doc Link 19043273 Disease Relevance 0.08 Pain Relevance 0.41
However, at higher doses of sunitinib in group D, both the AST and ALT levels were significantly increased (Figure 1).
Gene_expression (levels) of ALT
12) Confidence 0.61 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0.42 Pain Relevance 0.42
In contrast, after sunitinib was administered at escalating doses, the serum AST and ALT levels were only slightly elevated and mild liver damage with slight vascular congestion and signs of hepatocyte regeneration were found (Figure 3).
Gene_expression (levels) of ALT in hepatocyte associated with hepatotoxicity
13) Confidence 0.61 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0.55 Pain Relevance 0.50
Parallel to AST, there was a significant ALT elevation in the coadministration group at 100 mg/kg (p < 0.05) and 140 mg/kg (p < 0.01) doses of sunitinib.
Gene_expression (elevation) of ALT
14) Confidence 0.61 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0 Pain Relevance 0.53
Serum level of alanine transaminase (ALT) analysis
Gene_expression (analysis) of ALT
15) Confidence 0.61 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386525 Disease Relevance 0 Pain Relevance 0
Expectedly, MCS treatment significantly reduced ALT level after LPS injection.
Gene_expression (level) of ALT
16) Confidence 0.61 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386525 Disease Relevance 1.01 Pain Relevance 0.07
A detailed time course indicated that aminoguanidine (15 mg/kg at 0 h and 15 mg/kg at 2 h) significantly increased serum ALT levels over that for acetaminophen alone at 2 and 4 h; however, at 6 and 8 h serum ALT levels in the two groups were identical.
Gene_expression (levels) of ALT associated with paracetamol
17) Confidence 0.58 Published 2002 Journal Nitric Oxide Section Abstract Doc Link 11890740 Disease Relevance 0.38 Pain Relevance 0.92
Eight hours after the APAP injection, the levels of serum aminotransferase (AST) and alanine aminotransferase (ALT) were measured and liver, kidney and lung tissue were examined for morphological changes.
Spec (examined) Gene_expression (levels) of ALT in lung associated with paracetamol
18) Confidence 0.58 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19109935 Disease Relevance 0.66 Pain Relevance 0.64
gpt Mutations in the kidneys of gpt transgenic mice with particle treatment
Gene_expression (transgenic mice) of gpt associated with targeted disruption
19) Confidence 0.58 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2745356 Disease Relevance 0.18 Pain Relevance 0
gpt Mutations in the lungs of gpt transgenic mice with particle treatment
Gene_expression (transgenic mice) of gpt in lungs associated with targeted disruption
20) Confidence 0.58 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2745356 Disease Relevance 0.41 Pain Relevance 0

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