INT175642

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Context Info
Confidence 0.10
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.97
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL4A4)
Anatomy Link Frequency
chondrocytes 2
blood 2
PC-3 2
COL4A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 23 75.84 Quite High
cytokine 14 62.96 Quite High
Osteoarthritis 27 55.04 Quite High
tolerance 20 5.00 Very Low Very Low Very Low
metalloproteinase 19 5.00 Very Low Very Low Very Low
Kinase C 9 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
bradykinin 4 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 37 99.96 Very High Very High Very High
Prostate Cancer 87 99.84 Very High Very High Very High
Metastasis 33 97.04 Very High Very High Very High
Renal Disease 4 96.04 Very High Very High Very High
Cancer 39 95.12 Very High Very High Very High
Adhesions 47 94.32 High High
Diabetes Mellitus 202 92.84 High High
Diabetes Mellitus-type I 2 88.24 High High
Atherosclerosis 25 86.04 High High
Rheumatoid Arthritis 1 81.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The marked GS-mediated increase of these proteins in chondrocytes points to an elevation in ECM protein synthesis, which might be also hypothesized by the detected increase in Type IV Collagen (COL6A1, essential for chondrocyte anchoring to the pericellular matrix [49]) synthesis caused by GS.
Positive_regulation (increase) of Gene_expression (synthesis) of Type IV Collagen in chondrocytes
1) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.35 Pain Relevance 0.13
A variety of markers indicate endothelial dysfunction including: poor EC-dependent vasodilation, increased blood levels of von Willebrand factor (vWF), thrombomodulin, selectin, PAI-1, type IV collagen and t-PA were demonstrated in this patients population (Yaqoob et al 1993; Dosquet et al 1994; Myrup et al 1994; Makimattila et al 1996; Huszka et al 1997; Cosentino and Luscher 1998; Elhadd et al 1998; Malamitsi et al 1998; Huvers et al 1999).
Positive_regulation (increased) of Gene_expression (levels) of type IV collagen in blood associated with increased venous pressure under development
2) Confidence 0.05 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.64 Pain Relevance 0
For example, when prostate cells are transformed with the neu oncogene, collagen IV is overexpressed in PCa cell lines PC-3 and NbE1.4 [30,31]; while laminin alone is up-regulated in NbE1.4 [31] and the calcium-independent intercellular cell adhesion molecule-7 (ICAM-1) is down-regulated in PC-3 cells [30].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of collagen IV in PC-3 associated with prostate cancer and adhesions
3) Confidence 0.04 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 0.99 Pain Relevance 0

General Comments

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