INT175646

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Context Info
Confidence 0.02
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.41
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (LAMB2) cell adhesion (LAMB2) structural molecule activity (LAMB2)
Anatomy Link Frequency
basement membrane 2
LAMB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 29 100.00 Very High Very High Very High
COX-2 inhibitor 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 82 99.48 Very High Very High Very High
Prostate Cancer 87 87.20 High High
Melanoma 5 85.08 High High
Adhesions 28 80.72 Quite High
Metastasis 35 62.60 Quite High
Reprotox - General 1 26 51.96 Quite High
Adenocarcinoma 1 46.52 Quite Low
Carcinoma 4 31.60 Quite Low
Hypoxia 2 5.68 Low Low
Apoptosis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our study celecoxib was able to neutralize the inductive potential of the tumor cell microenvironment by decreasing levels of MMPs, TIMP1, TIMP2, and laminin (Figures 4 and 5).
Negative_regulation (decreasing) of Gene_expression (levels) of laminin associated with cancer and metalloproteinase
1) Confidence 0.02 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.47 Pain Relevance 0.14
In the same study, they also documented a dramatic loss of laminin expression indicating a break in the basement membrane adjacent to the tumor cells.
Negative_regulation (loss) of Gene_expression (expression) of laminin in basement membrane associated with cancer
2) Confidence 0.01 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 0.94 Pain Relevance 0

General Comments

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