INT17565

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 1982
Last Reported 2010
Negated 23
Speculated 4
Reported most in Body
Documents 85
Total Number 89
Disease Relevance 43.64
Pain Relevance 13.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cytoplasm (Gpt)
Anatomy Link Frequency
plasma 14
liver 8
blood 4
upper 3
hepatocytes 1
Gpt (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 618 100.00 Very High Very High Very High
adenocard 1 99.56 Very High Very High Very High
ischemia 84 99.20 Very High Very High Very High
Inflammation 113 99.12 Very High Very High Very High
imagery 33 99.12 Very High Very High Very High
lidocaine 12 98.24 Very High Very High Very High
alcohol 158 97.52 Very High Very High Very High
Bile 38 97.32 Very High Very High Very High
analgesia 3 95.08 Very High Very High Very High
Gabapentin 3 95.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatotoxicity 106 100.00 Very High Very High Very High
Immunization 57 100.00 Very High Very High Very High
Hemorrhagic Shock 15 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 11 100.00 Very High Very High Very High
Injury 427 99.92 Very High Very High Very High
Hepatic Encephalopathy 9 99.72 Very High Very High Very High
Hepatitis C Virus Infection 66 99.62 Very High Very High Very High
Body Weight 139 99.52 Very High Very High Very High
Hepatitis B Virus Infection 63 99.52 Very High Very High Very High
Hepatocellular Cancer 88 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall beneficial effects on mortality, liver necrosis score, and plasma alanine aminotransferase (ALT) activity were found in diltiazem-treated mice 24 h after acetaminophen overdose.
Regulation (effects) of ALT in plasma associated with paracetamol, hepatotoxicity and overdose
1) Confidence 0.60 Published 1995 Journal Liver Section Abstract Doc Link 7776852 Disease Relevance 0.55 Pain Relevance 0.47
The effects of sodium sulphate (200 mg/kg) in combination with NAC (400 mg/kg) administered intraperitoneally 2 h post-PCM dose, on mortality rate and plasma activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were investigated in mice 24 h after receiving a single oral dose of 400 mg/kg PCM.
Spec (investigated) Regulation (effects) of ALT in plasma associated with paracetamol
2) Confidence 0.43 Published 1998 Journal Inflammopharmacology Section Abstract Doc Link 17657622 Disease Relevance 0.17 Pain Relevance 0.69
Administration of Jo2 alone increased hepatic inducible nitric oxide synthase nitric oxide synthase but did not modify serum alanine aminotransferase (ALT), hepatic adenosine triphosphate (ATP), glutathione (GSH), cytochrome P-450, cytosolic cytochrome c, caspase-3 activity or hepatic morphology.
Neg (not) Regulation (modify) of ALT associated with adenocard
3) Confidence 0.40 Published 2004 Journal Hepatology Section Abstract Doc Link 14999684 Disease Relevance 0.60 Pain Relevance 0.30
TSM by itself, however, did not affect the hepatic functional parameters, including serum ALT, TBARS, GSH, SOD, or coenzymes Q in the liver.
Neg (not) Regulation (affect) of ALT in liver
4) Confidence 0.36 Published 2004 Journal J. Agric. Food Chem. Section Abstract Doc Link 15291509 Disease Relevance 0.23 Pain Relevance 0.07
ALT levels were negligible in both groups by the survival time-point.
Regulation (negligible) of ALT
5) Confidence 0.29 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.44 Pain Relevance 0.05
The diagnostic values of GGT, ALT, triglycerides, cholesterol, glucose and BMI were expected, because they had been previously associated with steatosis of different origins [3,29,31].
Regulation (values) of ALT associated with obesity
6) Confidence 0.28 Published 2005 Journal Comp Hepatol Section Body Doc Link PMC1327680 Disease Relevance 0.57 Pain Relevance 0.11
In addition, serum chemistry tests revealed that AST and ALT activity levels did not differ significantly from the V group.
Neg (not) Regulation (differ) of ALT
7) Confidence 0.28 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991689 Disease Relevance 0.21 Pain Relevance 0
AIM: To determine the effect of 10 days of the maximal therapeutic dose of paracetamol on serum alanine aminotransferase (ALT) activity in subjects who consume 1 to 3 alcoholic beverages per day.
Regulation (effect) of ALT
8) Confidence 0.27 Published 2007 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 17593074 Disease Relevance 0 Pain Relevance 0
The levels of plasma alanine transaminase (ALT) and aspartate transaminase (AST) were determined for each group after treatment.
Spec (determined) Regulation (determined) of ALT in plasma
9) Confidence 0.27 Published 2004 Journal Chin. Med. J. Section Body Doc Link 14975216 Disease Relevance 0.07 Pain Relevance 0
In the present study, test substance-phagocytized macrophages and granulomas were frequently observed in the lungs, and the degree of the granulomas formation was partly associated with the mutagenic effect on gpt gene by particles.
Regulation (effect) of gpt gene in lungs associated with granuloma
10) Confidence 0.27 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2745356 Disease Relevance 0.26 Pain Relevance 0
Though, paracetamol is regarded as a safe drug at therapeutic doses; at larger or chronic doses may result in severe liver and renal injuries [30], including changes in alkaline phosphatase (ALP), AST, ALT and creatinine plasma levels [31] which could be additive to those of sunitinib [10].
Regulation (changes) of ALT in plasma associated with paracetamol and injury
11) Confidence 0.24 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 0.82 Pain Relevance 0.59
The enzymes such as ALT, AST, ACP and ALP are responsible for the proper functioning of the liver and any damages induced in the liver due to the hyperglycemic conditions may lead to excessive leakage of these enzymes in the blood stream.
Regulation (responsible) of ALT in blood
12) Confidence 0.23 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2914719 Disease Relevance 0.49 Pain Relevance 0.03
The extract had no significant effect on the increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin in CCl(4) treated animals (p > 0.05).
Neg (no) Regulation (effect) of ALT
13) Confidence 0.22 Published 2006 Journal Phytother Res Section Abstract Doc Link 16619345 Disease Relevance 0.18 Pain Relevance 0.66
While on long-term acetaminophen treatment, 181 of 1039 (17.4%) patients had an ALT value that exceeded the upper limit of the reference range.
Regulation (value) of ALT in upper
14) Confidence 0.21 Published 2006 Journal Curr Med Res Opin Section Body Doc Link 17076974 Disease Relevance 0 Pain Relevance 0
Therapeutic acetaminophen dosing in a total of 132 subjects showed no effect on serum ALT, AST, bilirubin or INR.
Neg (no) Regulation (effect) of serum ALT associated with paracetamol
15) Confidence 0.18 Published 2007 Journal BMC Med Section Body Doc Link PMC1894983 Disease Relevance 0.07 Pain Relevance 0.49
The values {Area under the ROC curves (AUROCs)} of ST, GGT and ALT for the diagnosis of grades 2–4 steatosis, in the training and validation groups, are given in Table 3.
Regulation (values) of ALT
16) Confidence 0.18 Published 2005 Journal Comp Hepatol Section Body Doc Link PMC1327680 Disease Relevance 0.40 Pain Relevance 0
We also observed dyslipidemia and expected high HDL-c levels in C57BL/6 mice [22], with altered high plasma levels of ALT, AST and ALK.
Regulation (altered) of ALT in plasma associated with disorder of lipid metabolism
17) Confidence 0.16 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872226 Disease Relevance 0.58 Pain Relevance 0.07
Effects of the oil plastic extract were observed on blood elements, serum transaminases (aspartate aminotransferase, AST, and alanine aminotransferase, ALT), organ-to-body weight of the liver, kidneys and brain, and the nervous system (effects on the neuromuscular junction and analgesia, using the Rota-Rod(R) treadmill 'RRT', and the hot plate, respectively).
Regulation (Effects) of ALT in body associated with body weight and analgesia
18) Confidence 0.16 Published 2001 Journal Int J Environ Health Res Section Abstract Doc Link 11260789 Disease Relevance 0.36 Pain Relevance 0.10
Demonstration of hepatocellular injury by changes in plasma ALT levels
Regulation (changes) of ALT in plasma associated with injury
19) Confidence 0.15 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.19 Pain Relevance 0.04
Effects of VEGFR-mAbs on the serum ALT and survival rate
Regulation (mAbs) of serum ALT
20) Confidence 0.15 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2933582 Disease Relevance 0.53 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox