INT175651

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 2.59
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CDH2) plasma membrane (CDH2)
Anatomy Link Frequency
stromal cells 1
PC-3 1
heart 1
CDH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 14 17.44 Low Low
chemokine 4 16.64 Low Low
metalloproteinase 47 5.00 Very Low Very Low Very Low
backache 40 5.00 Very Low Very Low Very Low
Osteoarthritis 15 5.00 Very Low Very Low Very Low
imagery 15 5.00 Very Low Very Low Very Low
Inflammation 11 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 7 99.20 Very High Very High Very High
Prostate Cancer 174 98.68 Very High Very High Very High
Cancer 86 93.68 High High
Metastasis 66 86.88 High High
Carcinoma 8 81.60 Quite High
Necrosis 10 77.92 Quite High
Adhesions 69 75.88 Quite High
Muscle Disease 4 57.68 Quite High
Vohwinkel Syndrome 3 56.16 Quite High
Syndrome 4 54.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of a subset of the validated bovine markers genes (KRT8, 18, 19 SNAP25, CDH2, TNMD, BASP1, FOXF1, IBSP and FBLN 1) was analysed in human cells.
Spec (analysed) Gene_expression (Expression) of CDH2
1) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
N-cadherin (CDH2) was also highly differentially expressed and was selected along with synaptosomal-associated protein, 25 kDa (SNAP25) and sclerostin domain containing 1 (SOSTDC1) as NP-specific markers for further analysis.
Gene_expression (expressed) of CDH2
2) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0.16 Pain Relevance 0
Eleven genes (SNAP25, KRT8, KRT18, KRT19, CDH2, IBSP, VCAN, TNMD, BASP1, FOXF1 & FBLN1) were also differentially expressed in normal human NP cells, although to a lesser degree.
Gene_expression (expressed) of CDH2
3) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
Analysis of NP-specific marker genes in degenerate samples (Figure 6a) showed a significant decrease in expression for SNAP25, KRT8, KRT18 and CDH2 in degenerate NP cells when compared with normal NP cells (P = 0.0002, P = 0.0003, P < 0.0001 and P = 0.0001, respectively).
Gene_expression (expression) of CDH2
4) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
Analysis of the NP-specific marker genes (SNAP25, KRT8, KRT18, KRT19, CDH2 and SOSTDC1; Figure 3a) demonstrated significantly higher expression in NP cells when compared with either AF (all genes P < 0.0001) or AC cells (all genes P < 0.0001), which confirmed the microarray findings.
Gene_expression (expression) of CDH2
5) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
PE [14], suggesting that N-cadherin expression is inhibited by P.
Gene_expression (expression) of N-cadherin
6) Confidence 0.16 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775064 Disease Relevance 0.09 Pain Relevance 0
Conversely, the expression of N-cadherin in PC-3 cells [49] and advanced prostatic carcinomas [37] has been demonstrated to increase.
Gene_expression (expression) of N-cadherin in PC-3 associated with prostate cancer
7) Confidence 0.06 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 1.08 Pain Relevance 0
This would be expected because N-cadherin expression in highly invasive breast cancers was found to replace E-cadherin in facilitating cell:cell contacts, and thought to mediate the interaction between mammary tumor and stromal cells [51].
Gene_expression (expression) of N-cadherin in stromal cells associated with cancer and breast cancer
8) Confidence 0.06 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 1.04 Pain Relevance 0
N-cadherin is the predominant isoform expressed in the human heart.
Gene_expression (expressed) of N-cadherin in heart
9) Confidence 0.04 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2222049 Disease Relevance 0.22 Pain Relevance 0

General Comments

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