INT175685

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 8.18
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Anatomy Link Frequency
ventricle 4
lungs 4
liver 2
spinal cord 2
plaque 2
Timp1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 98 100.00 Very High Very High Very High
fibrosis 158 99.70 Very High Very High Very High
cytokine 96 98.38 Very High Very High Very High
Spinal cord 11 97.44 Very High Very High Very High
Inflammation 195 96.48 Very High Very High Very High
beta blocker 5 84.84 Quite High
agonist 3 75.60 Quite High
chemokine 9 61.32 Quite High
Angina 4 60.60 Quite High
Glutamate 21 59.56 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 63 99.88 Very High Very High Very High
Stomach Cancer 58 99.84 Very High Very High Very High
Pulmonary Fibrosis 66 99.70 Very High Very High Very High
Aging 6 99.56 Very High Very High Very High
Cirrhosis 16 99.36 Very High Very High Very High
Hyperplasia 4 99.08 Very High Very High Very High
Cv General 4 Under Development 385 98.64 Very High Very High Very High
Fibrosis 95 98.40 Very High Very High Very High
INFLAMMATION 200 96.48 Very High Very High Very High
Motor Neuron Diseases 198 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased TIMP-1 expression has been observed in lung extracts and in BAL fluids after bleomycin administration and after the transfer of the active TGF-beta gene to "fibrosis-prone" C57BL/6 mice [11,14].
Positive_regulation (Increased) of Gene_expression (expression) of TIMP in lung associated with fibrosis
1) Confidence 0.57 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.64 Pain Relevance 0.31
Bleomycin-induced pulmonary fibrosis, for example, causes the expression of significant levels of TIMP-1 [13,14].
Positive_regulation (causes) of Gene_expression (expression) of TIMP associated with fibrosis and pulmonary fibrosis
2) Confidence 0.38 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.64 Pain Relevance 0.40
In addition, transgenic mice overexpressing human TIMP-1 developed more liver fibrosis when subjected to chronic CCl4 administration [39], and demonstrated attenuated spontaneous fibrosis resolution [40].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of TIMP-1 in liver associated with targeted disruption, fibrosis and cirrhosis
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 1.20 Pain Relevance 0.48
In contrast, we find that silica induced expression of the MMP inhibitor, TIMP1, in the lung of mice, and this enhanced expression was not altered in the lungs of the CCSP-dnI?
Positive_regulation (induced) of Gene_expression (expression) of TIMP1 in lungs
4) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.32 Pain Relevance 0.16
As in our study, TIMP1 levels have been found to be elevated in gastric cancer patients compared to healthy controls [50,51].
Positive_regulation (elevated) of Gene_expression (levels) of TIMP1 associated with stomach cancer
5) Confidence 0.19 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.74 Pain Relevance 0.03
With aging, however, a shift to increased myocardial TIMP levels and an overall reduction in the MMP/TIMP ratio, an increase in collagen production, and subsequent fibrosis of the dilated ventricle was observed.
Positive_regulation (increase) of Gene_expression (levels) of TIMP in ventricle associated with fibrosis and aging
6) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 0.76 Pain Relevance 0.30
With aging, however, a shift to increased myocardial TIMP levels and an overall reduction in the MMP/TIMP ratio, an increase in collagen production, and subsequent fibrosis of the dilated ventricle was observed.
Positive_regulation (increased) of Gene_expression (levels) of TIMP in ventricle associated with fibrosis and aging
7) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257451 Disease Relevance 0.69 Pain Relevance 0.29
The ability of culture supernatants from IL-6/sIL-6R-stimulated cells to inhibit collagen digestion in IL-1-stimulated synovial cells further supports IL-6-induced TIMP production and the role of IL-6 in extracellular matrix turnover [58].


Positive_regulation (supports) of Gene_expression (production) of TIMP in extracellular matrix
8) Confidence 0.12 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.83 Pain Relevance 0
Macrophages then induce those growth factors and cytokines, which mediate intimal hyperplasia and contribute to plaque instability through enhancing levels of matrix metalloproteinases (MMPs) and other hydrolytic enzymes.
Positive_regulation (enhancing) of Gene_expression (levels) of metalloproteinases in plaque associated with metalloproteinase, hyperplasia and cytokine
9) Confidence 0.04 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 0.65 Pain Relevance 0.26
In Nunavik, levels of EPA and DHA increased linearly with mercury blood concentrations (r = 0.50, p < 0.0001; r = 0.60, p < 0.0001 respectively). n-3 fatty acids can positively modulate HRV [34-36] as DHA can slow the heart rate [37,38], prevent ventricular arrhythmias [39], and sudden death [40]. n-3 fatty acids could also have a protective effect on BP [41,42].
Positive_regulation (increased) of Gene_expression (levels) of EPA in heart associated with sudden death
10) Confidence 0.01 Published 2008 Journal Environ Health Section Body Doc Link PMC2443124 Disease Relevance 0.50 Pain Relevance 0.04
An increased expression of matrix metalloproteinases and the degradation of the extra-cellular matrix in postmortem spinal cord tissue have been observed in ALS.139 RO-28-2653 prolonged survival in familial ALS mice if given before the onset of symptoms;139 however, the administration of the drug at disease onset did not significantly improve survival time.139 Despite the unique mechanism of action among ALS relevant therapies, there is a lack of safety or efficacy data for this agent in ALS patients.24

ONO-2506

Positive_regulation (increased) of Gene_expression (expression) of metalloproteinases in spinal cord associated with metalloproteinase, disease, motor neuron diseases and spinal cord
11) Confidence 0.01 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785861 Disease Relevance 1.21 Pain Relevance 0.31

General Comments

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