INT175687

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Context Info
Confidence 0.72
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.12
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
macrophages 1
muscle 1
adipocyte 1
nervous system 1
Apoe (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 92 99.72 Very High Very High Very High
Neuritis 24 51.16 Quite High
Multiple sclerosis 7 46.24 Quite Low
metalloproteinase 13 44.64 Quite Low
withdrawal 10 32.32 Quite Low
Inflammation 18 11.08 Low Low
cytokine 16 5.00 Very Low Very Low Very Low
Peripheral nervous system 5 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 24 99.64 Very High Very High Very High
Disease 74 97.44 Very High Very High Very High
Atherosclerosis 32 97.16 Very High Very High Very High
Hyperlipidemia 16 96.36 Very High Very High Very High
Targeted Disruption 20 92.16 High High
Cognitive Disorder 10 90.84 High High
Disorder Of Lipid Metabolism 13 82.96 Quite High
Yersinia Infection 1 68.64 Quite High
Experimental Autoimmune Neuritis 24 51.16 Quite High
Syndrome 19 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the nervous system, apoE mRNA is present in neurons, astrocytes, ependymal cells, nonmyelinating Schwann cells, but not in microglia, oligodendroglia, choroidal cells, or myelinating Schwann cells [6–8].
Neg (not) Transcription (present) of apoE in nervous system
1) Confidence 0.72 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.24 Pain Relevance 0.10
In contrast to mMSCs, unmanipulated human MSCs (hMSCs) do not synthesize ApoE mRNA in vitro, but expression could be observed after 7 days of adipocyte differentiation [25].
Neg (not) Transcription (synthesize) of ApoE in adipocyte
2) Confidence 0.22 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.47 Pain Relevance 0.03
Expression of ApoE mRNA by adipocytes was increased by pioglitazone and ciglitazone, neither of which affected the ApoE secretion of macrophages [29].
Transcription (Expression) of ApoE in macrophages associated with obesity
3) Confidence 0.22 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.41 Pain Relevance 0.16
Harris et al (2002) found that they could detect apoE mRNA in the muscle from a single intramuscular injection into the apoE?
Transcription (detect) of apoE in muscle
4) Confidence 0.14 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 1.00 Pain Relevance 0

General Comments

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