INT175688

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Context Info
Confidence 0.16
First Reported 2003
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 8.72
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
extracellular matrix 3
endothelial cells 2
liver 1
cardiac myocytes 1
cleavage 1
smc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 261 96.88 Very High Very High Very High
bradykinin 1 87.16 High High
cytokine 150 85.20 High High
fibrosis 39 84.84 Quite High
Percutaneous transluminal coronary angioplasty 4 74.88 Quite High
agonist 3 72.24 Quite High
Neurotransmitter 60 70.96 Quite High
chemokine 32 69.84 Quite High
imagery 13 66.68 Quite High
metalloproteinase 52 57.32 Quite High
Disease Link Frequency Relevance Heat
Adhesions 70 100.00 Very High Very High Very High
Hypoxia 443 99.36 Very High Very High Very High
INFLAMMATION 262 97.60 Very High Very High Very High
Neointima 41 96.44 Very High Very High Very High
Apoptosis 88 96.08 Very High Very High Very High
Retinoblastoma 4 94.48 High High
Hyperplasia 21 92.48 High High
Natriuresis 8 86.16 High High
Syndrome 9 86.08 High High
Cystic Fibrosis 35 84.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Simply, are the observed SMC responses shown in Figures 3 and 4 really olfactory driven or do they merely represent planned/actual behavioral action, such as licking of the reward tube?
Gene_expression (responses) of SMC in tube
1) Confidence 0.16 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573932 Disease Relevance 0 Pain Relevance 0
Interestingly, a recent study demonstrated that CFTR is also expressed in tracheal SMC and may contribute to bronchodilation [36].
Gene_expression (expressed) of SMC
2) Confidence 0.15 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.93 Pain Relevance 0.31
m; mean SMC length: 204±9 ?
Gene_expression (length) of SMC
3) Confidence 0.14 Published 2007 Journal Neuroscience Section Body Doc Link PMC2543106 Disease Relevance 0 Pain Relevance 0.06
However, the entire SMC could not be simultaneously viewed within one confocal optical section (mean field: 94 ?
Neg (not) Gene_expression (viewed) of SMC
4) Confidence 0.14 Published 2007 Journal Neuroscience Section Body Doc Link PMC2543106 Disease Relevance 0 Pain Relevance 0.07
Inhibitory effects of fucoidan on SMC proliferation, migration, and adhesion
Gene_expression (proliferation) of SMC associated with adhesions
5) Confidence 0.13 Published 2010 Journal The Korean Journal of Hematology Section Body Doc Link PMC2983006 Disease Relevance 0.38 Pain Relevance 0.06
In addition, fucoidan inhibited SMC migration and SMC adhesion to extracellular matrix to a greater extent than heparin (data not shown).
Gene_expression (adhesion) of SMC in extracellular matrix associated with adhesions
6) Confidence 0.13 Published 2010 Journal The Korean Journal of Hematology Section Body Doc Link PMC2983006 Disease Relevance 0.45 Pain Relevance 0.19
In addition, fucoidan inhibited SMC migration and SMC adhesion to extracellular matrix to a greater extent than heparin (data not shown).
Gene_expression (migration) of SMC in extracellular matrix associated with adhesions
7) Confidence 0.13 Published 2010 Journal The Korean Journal of Hematology Section Body Doc Link PMC2983006 Disease Relevance 0.44 Pain Relevance 0.19
Cardiac vascular EC had mild COX-2 expression, while cardiac myocytes and cardiac vascular SMC were negative.
Neg (negative) Gene_expression (negative) of SMC in cardiac myocytes
8) Confidence 0.09 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0 Pain Relevance 0
In the lungs and heart, COX-1 was strongly expressed in alveolar macrophages, the bronchial and bronchiolar epithelium, and cardiac vascular endothelial cells, but moderately expressed in alveolar septa, bronchial smooth muscle cells, pulmonary vascular endothelial cells, pulmonary vascular EC, and cardiac vascular SMC.
Gene_expression (expressed) of SMC in endothelial cells
9) Confidence 0.07 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0 Pain Relevance 0
In the lungs and heart, COX-1 was strongly expressed in alveolar macrophages, the bronchial and bronchiolar epithelium, and cardiac vascular endothelial cells, but moderately expressed in alveolar septa, bronchial smooth muscle cells, pulmonary vascular endothelial cells, pulmonary vascular EC, and cardiac vascular SMC.
Gene_expression (expressed) of SMC in endothelial cells
10) Confidence 0.07 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0 Pain Relevance 0.03
SMC, while no expression was present in other renal or cardiac microanatomic
Neg (no) Gene_expression (expression) of SMC
11) Confidence 0.07 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0.38 Pain Relevance 0.07
Histopathological analyses of post hemorrhagic organs clearly revealed lower numbers of neutrophils within the pulmonary tissues and slightly less numbers in heart, liver, kidney and bowel in animals of the LIM group versus SMC.
Gene_expression (group) of SMC in liver
12) Confidence 0.05 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873502 Disease Relevance 0.36 Pain Relevance 0.03
Culture of SMC on extracellular matrix material (ECM)
Gene_expression (Culture) of SMC in extracellular matrix
13) Confidence 0.05 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
In the human saphenous vein model of vein graft, targeting SMC by
Gene_expression (targeting) of SMC in vein
14) Confidence 0.04 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 1.03 Pain Relevance 0.08
Targeting SMC proliferation has also been shown to be effective using gene therapy protocols.
Gene_expression (proliferation) of SMC
15) Confidence 0.04 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 0.92 Pain Relevance 0.15
Hirudin is perhaps the most potent inhibitor of thrombin, the enzyme responsible for fibrinogen cleavage, platelet activation, and SMC proliferation [54].
Gene_expression (cleavage) of SMC in platelet
16) Confidence 0.04 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 0.33 Pain Relevance 0.04
PA-SMC suspension, 200 ?
Gene_expression (suspension) of PA-SMC
17) Confidence 0.03 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0 Pain Relevance 0
Effect of IL-6 on human PA-SMC proliferation
Gene_expression (proliferation) of PA-SMC
18) Confidence 0.03 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0 Pain Relevance 0
Combining IL-6 and sIL-6R further increased PA-SMC migration (Figure 6a).
Gene_expression (migration) of PA-SMC
19) Confidence 0.03 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.94 Pain Relevance 0.03
These data, together with our finding that exposure to chronic hypoxia is associated with increased lung expression of IL-6R and gp-130 mRNA levels, strongly suggest that IL-6 may act partly as an inducer of PA-SMC migration during chronic hypoxia.
Gene_expression (migration) of PA-SMC in lung associated with hypoxia
20) Confidence 0.03 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.30 Pain Relevance 0.05

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