INT175691

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 7.87
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lcat) extracellular region (Lcat) transferase activity, transferring acyl groups (Lcat)
lipid metabolic process (Lcat)
Anatomy Link Frequency
liver 2
eye 1
plaque 1
Lcat (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 21 91.00 High High
agonist 85 69.60 Quite High
Inflammation 51 23.44 Low Low
metalloproteinase 13 21.20 Low Low
alcohol 45 5.00 Very Low Very Low Very Low
Angina 18 5.00 Very Low Very Low Very Low
ischemia 8 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
aspirin 6 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 45 99.84 Very High Very High Very High
Disorder Of Lipid Metabolism 1455 99.44 Very High Very High Very High
Syndrome 5 99.28 Very High Very High Very High
Atherosclerosis 272 98.76 Very High Very High Very High
Eye Disease 6 98.50 Very High Very High Very High
Coronary Heart Disease 202 96.96 Very High Very High Very High
Renal Failure 4 95.00 High High
Anaemia 4 94.28 High High
Disease 36 93.84 High High
Diabetes Mellitus 24 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mediating this necessary step in HDL-C maturation is the enzyme LCAT, which is synthesized by the liver.
Gene_expression (synthesized) of LCAT in liver associated with disorder of lipid metabolism
1) Confidence 0.57 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.25 Pain Relevance 0.07
Familial LCAT deficiency (FLD) and fish-eye disease (FED) are distinct inherited syndromes associated with absent or impaired LCAT expression, respectively.
Neg (absent) Gene_expression (expression) of LCAT in eye associated with syndrome and eye disease
2) Confidence 0.57 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.60 Pain Relevance 0
Conversely, over expression of human LCAT in transgenic animal models correlates with a 7-fold increase in serum HDL-C, increases in Apo AI levels, and a marked reduction in atheromatous plaque burden (Francone et al 1990).
Gene_expression (expression) of LCAT in plaque associated with targeted disruption and disorder of lipid metabolism
3) Confidence 0.49 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.69 Pain Relevance 0
These findings suggest that LCAT over expression may serve as a novel therapeutic target in the prevention and treatment of CHD.


Gene_expression (expression) of LCAT associated with coronary heart disease
4) Confidence 0.49 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.53 Pain Relevance 0.03
Once cholesterol gets associated with HDL, it becomes esterified through the action of another enzyme, LCAT.13 Cholesterol ester, thus produced, is, again, hydrophobic and it accumulates to the center of the lipoprotein molecule, producing mature HDL.14 Subsequently, the mature HDL is transported to the liver where it releases the cholesterol for excretion into the bile.
Gene_expression (produced) of LCAT in liver associated with bile and disorder of lipid metabolism
5) Confidence 0.39 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.78 Pain Relevance 0.11
vitro bicistronic expression of these two genes from AAV plasmid vectors, it was shown that increased synthesis of apoAI and LCAT could play a role in reducing atherosclerotic risk [61].
Gene_expression (synthesis) of LCAT associated with atherosclerosis
6) Confidence 0.29 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 1.02 Pain Relevance 0

General Comments

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