INT175702

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.46
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (E2F2) nucleus (E2F2) DNA binding (E2F2)
transcription factor binding (E2F2)
E2F2 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 130 81.32 Quite High
metalloproteinase 13 76.48 Quite High
aspirin 1 37.12 Quite Low
Inflammation 5 18.28 Low Low
Pain 1 17.60 Low Low
Angina 3 17.44 Low Low
cytokine 1 5.00 Very Low Very Low Very Low
Rostral ventrolateral medulla 1 5.00 Very Low Very Low Very Low
Percutaneous transluminal coronary angioplasty 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 6 85.12 High High
Breast Cancer 2 77.28 Quite High
Neointima 8 72.72 Quite High
Reprotox - General 1 4 57.12 Quite High
Squamous Cell Carcinoma 1 56.08 Quite High
Cancer 44 51.32 Quite High
Small Cell Lung Cancer 63 50.00 Quite Low
Apoptosis 7 48.52 Quite Low
Stomach Cancer 2 39.64 Quite Low
Anaplastic Astrocytoma 1 38.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
E2F1, E2F2 and E2F3 are often referred to as “activator” E2Fs because they transcriptionally activate E2F target proliferative genes such as cyclin E, cdc25A and cdc6 [25], [27], [28], [29].
Positive_regulation (activate) of E2F
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.24 Pain Relevance 0.34
E2F upregulates up to a dozen cell cycle genes and its inhibition inhibits target cell cycle gene expression and DNA synthesis.
Positive_regulation (upregulates) of E2F
2) Confidence 0.01 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 0.21 Pain Relevance 0.12

General Comments

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