INT175703

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 3.47
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (E2F2) nucleus (E2F2) DNA binding (E2F2)
transcription factor binding (E2F2)
E2F2 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 520 99.98 Very High Very High Very High
withdrawal 3 99.12 Very High Very High Very High
Inflammation 20 95.28 Very High Very High Very High
cytokine 4 94.24 High High
COX2 6 86.84 High High
metalloproteinase 13 64.00 Quite High
agonist 18 62.76 Quite High
aspirin 1 44.52 Quite Low
antagonist 6 37.04 Quite Low
Angina 3 24.84 Low Low
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 252 99.04 Very High Very High Very High
INFLAMMATION 24 95.28 Very High Very High Very High
Cancer 207 94.88 High High
Retinoblastoma 4 93.44 High High
Obesity 6 88.08 High High
Lung Cancer 44 82.08 Quite High
Adenocarcinoma 6 76.92 Quite High
Apoptosis 124 76.16 Quite High
Metastasis 10 75.56 Quite High
Breast Cancer 22 74.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the treatment with the aglycon mixture caused a marginally stronger up- or downregulation of some genes, such as CCNE2, DNAJB9, E2F2, ESR1 and GADD45A.
Negative_regulation (downregulation) of E2F2
1) Confidence 0.38 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.23 Pain Relevance 0
These observations seemed to suggest that the anti-proliferative effect of capsaicin was correlated with a decrease in levels of E2F responsive S-phase genes in vivo.


Negative_regulation (decrease) of E2F associated with qutenza
2) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.75 Pain Relevance 0.78
Finally, chromatin IP (ChIP) analysis of human SCLC cells demonstrated that treatment of capsaicin decreased the recruitment of activator E2Fs, namely E2F2 and E2F3, to proliferative promoters like cyclin E, TS, cdc25A and cdc6.
Negative_regulation (decreased) of E2F2 associated with qutenza and small cell lung cancer
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.65 Pain Relevance 0.94
E2F family members E2F6, E2F7 and E2F8 are also repressors.
Negative_regulation (repressors) of E2F
4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.06 Pain Relevance 0.18
ChIP assays were performed to examine the relative distribution of E2Fs on E2F-responsive promoters in human SCLC cells.
Spec (examine) Negative_regulation (distribution) of E2F associated with small cell lung cancer
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.73 Pain Relevance 0.24
the phosphorylation of pRb, but also decreases the amount of “free” E2F
Negative_regulation (decreases) of E2F
6) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.09 Pain Relevance 0
inhibition of E2F/DP DNA binding [129], the inhibition of cyclins D1 and E,
Negative_regulation (inhibition) of E2F
7) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.30 Pain Relevance 0.14
preadipocytes via suppression of the transcriptional activity of E2F/DP
Negative_regulation (suppression) of E2F
8) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.39 Pain Relevance 0.08
By blockading the cell transcription factor E2F with decoy oligodeoxynucleoties at the time of grafting, they were able to significantly reduce the incidence of post-operative
Negative_regulation (blockading) of E2F
9) Confidence 0.01 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 0.27 Pain Relevance 0.09

General Comments

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