INT175710

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Context Info
Confidence 0.26
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.03
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Slc37a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 7 100.00 Very High Very High Very High
Dopamine 14 88.40 High High
Potency 1 84.92 Quite High
Sciatic nerve 1 77.56 Quite High
fluoxetine 1 69.88 Quite High
monoamine 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 4 99.74 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 33 93.68 High High
Targeted Disruption 2 89.24 High High
Hyperkinesis 1 73.80 Quite High
Hypertrophy 2 71.72 Quite High
Disease 1 67.84 Quite High
Obesity 2 58.56 Quite High
Anxiety Disorder 4 52.48 Quite High
Glycogen Storage Disease 1 30.96 Quite Low
Stress 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Grouping the orthologs by biological function revealed that two genes, Rrad (Ras associated with diabetes) and G6pt1 (glucose-6-phosphatase, transport protein 1), were regulated in directions suggesting decreased glucose transport, and one gene, Gpd2 (glycerol-3-phosphate dehydrogenase 2 (mitochondrial)) was regulated in a direction that suggested a decrease in glucose metabolism.
Regulation (regulated) of glucose-6-phosphatase, transport protein 1 associated with diabetes mellitus
1) Confidence 0.26 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0.36 Pain Relevance 0.04
Given the critical role of the serotonin transporter (5-HTT) in regulation of 5-HT transmission [12], the 5-HTT gene (SLC6A4) may be considered a suitable candidate gene to explain at least part of the variability in behavioral response to MPH.
Regulation (role) of transporter associated with serotonin
2) Confidence 0.01 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2905344 Disease Relevance 0.67 Pain Relevance 0.31

General Comments

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