INT175738

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Context Info
Confidence 0.28
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.29
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ARNTL) DNA binding (ARNTL) signal transducer activity (ARNTL)
Anatomy Link Frequency
skeletal muscle 1
ARNTL (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 5 29.36 Quite Low
Analgesic 1 29.12 Quite Low
Antiemetics 1 26.28 Quite Low
imagery 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
Sciatic nerve 3 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Emergencies 5 83.40 Quite High
Sepsis 4 77.52 Quite High
Bacterial Infection 1 70.32 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

3 60.88 Quite High
Oxidative Phosphorylation Disease 3 50.00 Quite Low
Disease 9 46.48 Quite Low
Cancer 3 45.40 Quite Low
Syndrome 16 40.64 Quite Low
Stress 9 35.72 Quite Low
Vomiting 2 26.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative RT-PCR also provided a potential explanation for our inability to detect a significant change in the expression of the circadian-regulated core clock genes Cry1 and Bmal1 in hSkM [19,20], as these genes cycle out of phase with Per1 and Per2 in mSkM (Figure 3) and in many other tissues, including mLvr [19] and mHrt [19].
Regulation (regulated) of Bmal1
1) Confidence 0.28 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0
This large-scale expression analysis of acute RE and circadian gene regulation in hSkM suggests that RE can directly regulate circadian clock genes (Per2, Cry1, and Bmal1) and circadian output genes.
Regulation (regulate) of Bmal1
2) Confidence 0.17 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0
The coordinated regulation of the circadian clock genes Cry1, Per2, and Bmal1 6 hours after RE and diurnal genes 18 hours after RE in the exercised leg suggest that RE may directly modulate circadian rhythms in human skeletal muscle.



Regulation (regulation) of Bmal1 in skeletal muscle
3) Confidence 0.17 Published 2003 Journal Genome Biol Section Abstract Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0
FSA, MMG, PAM, JGT, JAP, ELC and JGG were involved in the direct care of these patients.
Regulation (involved) of JAP
4) Confidence 0.00 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3018369 Disease Relevance 0.23 Pain Relevance 0

General Comments

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