INT17574

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Context Info
Confidence 0.31
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 4.30
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CISH) intracellular (CISH) molecular_function (CISH)
cellular_component (CISH)
Anatomy Link Frequency
neutrophil 2
plasma 1
margin 1
pore 1
platelets 1
CISH (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 19 97.60 Very High Very High Very High
Dynorphin 4 95.36 Very High Very High Very High
lidocaine 2 86.16 High High
MU agonist 1 85.76 High High
Inflammation 77 83.80 Quite High
COX-2 inhibitor 6 75.88 Quite High
cINOD 20 75.08 Quite High
metalloproteinase 124 69.64 Quite High
Central nervous system 12 68.16 Quite High
Kappa opioid receptor 1 65.20 Quite High
Disease Link Frequency Relevance Heat
Coronary Heart Disease 87 100.00 Very High Very High Very High
Pain 17 97.60 Very High Very High Very High
Germ Cell And Embryonal Neoplasms 1 96.76 Very High Very High Very High
Toxicity 30 93.92 High High
Cardiovascular Disease 107 93.56 High High
Cancer 30 92.24 High High
Stress 166 89.16 High High
Carcinoma In Situ 2 87.36 High High
Pulmonary Disease 10 86.04 High High
Congenital Anomalies 7 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Knowledge of the association of ultrasound and CIS is important to diagnose patients at the stage prior to development of an overt germ cell tumor.
CIS Binding (association) of in germ cell associated with germ cell and embryonal neoplasms
1) Confidence 0.31 Published 2005 Journal Asian J. Androl. Section Abstract Doc Link 16281095 Disease Relevance 1.14 Pain Relevance 0.10
At modest hyperthermic conditions (42 degrees C) 99.4% BCNU resistant cells are killed by a combination of BCNU and cis-DDP at drug concentrations identical to plasma concentrations after standard IV doses.
cis-DDP Binding (combination) of in plasma
2) Confidence 0.30 Published 1991 Journal J. Neurooncol. Section Abstract Doc Link 1919644 Disease Relevance 0.35 Pain Relevance 0.17
Among men, we observed TG to be inversely associated with all-cause mortality (HR 0.75, 95% CIs 0.56-1.00); WC showed no association with mortality (HR 0.90, 95% CIs 0.72-1.12).
CIs Neg (no) Binding (association) of
3) Confidence 0.15 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2949857 Disease Relevance 1.02 Pain Relevance 0
Additionally, the small number of respondents resulted in wide CIs for some associations.
CIs Binding (associations) of
4) Confidence 0.10 Published 2010 Journal J Urban Health Section Body Doc Link PMC2900569 Disease Relevance 0 Pain Relevance 0
Uncertainties in the regression dilution ratios calculated from the 300 participants with repeats in the Reykjavik Study were incorporated into the CIs for CHD associations by adding to the observed regression dilution ratios an error term sampled from the regression dilution ratio distribution on each bootstrap sample.
CIs Binding (associations) of associated with coronary heart disease
5) Confidence 0.10 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2288623 Disease Relevance 0.24 Pain Relevance 0.03
This interconnection and execution of a functional mRNA likely results from recognition and utilization of cis- and trans-acting signals.
cis Binding (recognition) of
6) Confidence 0.08 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1088970 Disease Relevance 0 Pain Relevance 0
Anyhow, these are not specific problems of NEAR interpretation; these are general problems of working with CIs.
CIs Binding (working) of
7) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570485 Disease Relevance 0.07 Pain Relevance 0
Individuals with CIs are unlikely to be able to take advantage of pinna cues, since the microphone of the speech processor is commonly positioned above the pinna, rather than within the entrance of the ear canal.
CIs Binding (Individuals) of in pinna
8) Confidence 0.06 Published 2010 Journal Journal of Neuroscience Methods Section Body Doc Link PMC2938482 Disease Relevance 0 Pain Relevance 0
Support for this hypothesis is derived from information obtained in human platelets and B lymphocytes, which suggests that TRPC1 is activated upon interaction with InsP3-Rs [57] and that it acts not only as a component of SOCs but also as a regulatory subunit of InsP3-Rs [58].
SOCs Binding (component) of in B lymphocytes
9) Confidence 0.06 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Recent studies provided evidence for the formation of a ternary complex among TRPC, Orai1, and STIM1 (Fig. 2), in which TRPC is the pore-forming component of SOCs and Orai1, the regulatory subunit that confers store depletion sensitivity to TRPC [77, 79].
SOCs Binding (component) of in pore
10) Confidence 0.06 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Although results obtained in other nonexcitable cells might provide an important means to ultimately resolve the molecular mystery of the SOCE pathway in neutrophils, they must be extrapolated with prudence to human neutrophils, and more studies will be necessary in these cells to define the exact arrangement of SOCs and mechanisms leading to their activation.


SOCs Binding (arrangement) of in neutrophils
11) Confidence 0.05 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
In most instances, the exact mechanisms by which they interfere with SOCs remain to be established, and nonspecific effects as a result of interference with other mechanisms important for Ca2+ signals, such as Ca2+ pumps, mitochondrial Ca2+ homeostasis, Ca2+ release, and activity of K+ channels, cannot be excluded.
SOCs Binding (interfere) of
12) Confidence 0.05 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.49 Pain Relevance 0.07
For both parameters the upper limits of the 90% CIs for the geometric mean ratios (sitaxentan to placebo) were outside the 80–125% equivalence window, indicating a statistically significant interaction between the two drugs, consistent with CYP3A4/5 inhibition.
CIs Binding (interaction) of in upper
13) Confidence 0.04 Published 2010 Journal British Journal of Clinical Pharmacology Section Body Doc Link PMC2805874 Disease Relevance 0 Pain Relevance 0
In light of previously published data, our results suggest that the modestly expanded FXTAS repeat sequence alters chromatin structure in cis, largely through preferential association with acetylated histones, which in turn promote transcription at the FMR1 locus, driving up FMR1 mRNA levels and potentially exacerbating RNA mediated toxicity.
cis Binding (association) of associated with toxicity
14) Confidence 0.03 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC3000359 Disease Relevance 0.09 Pain Relevance 0
Moreover, Geotrichum lipase exhibits a high degree of discrimination in favor of acids having a cis double bond at the ?
cis Binding (bond) of
15) Confidence 0.02 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635649 Disease Relevance 0 Pain Relevance 0
Some members of this family can bind to both cis-elements (GCC and CRT/DRE, respectively) albeit with different affinities, as in the case of the tobacco ethylene-inducible Tsi1 transcription factor.
cis Binding (bind) of
16) Confidence 0.02 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358903 Disease Relevance 0.21 Pain Relevance 0
Some enzymes associated with CIS, such as ?
CIS Binding (associated) of
17) Confidence 0.02 Published 2008 Journal BMC Genomics Section Abstract Doc Link PMC2358903 Disease Relevance 0 Pain Relevance 0
Support for this hypothesis is derived from information obtained in human platelets and B lymphocytes, which suggests that TRPC1 is activated upon interaction with InsP3-Rs [57] and that it acts not only as a component of SOCs but also as a regulatory subunit of InsP3-Rs [58].
SOCs Binding (component) of in platelets
18) Confidence 0.02 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
The upper bounds of the CIs for the relative differences for the comparisons between etoricoxib and placebo fell well below the prespecified non-inferiority margin of 80% for CRP and below 20% for fibrinogen, LDL-C, and homocysteine.
CIs Binding (bounds) of in margin
19) Confidence 0.02 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817438 Disease Relevance 0 Pain Relevance 0.11
Nrf2 activates the transcription of a multitude of downstream anti-oxidant genes via binding to the cis-acting anti-oxidant response element (ARE) of these genes (Nguyen et al., 2004).
cis-acting Binding (binding) of
20) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.57 Pain Relevance 0

General Comments

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