INT175747

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Context Info
Confidence 0.21
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.06
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring acyl groups (CLOCK) DNA binding (CLOCK) cytoplasm (CLOCK)
signal transducer activity (CLOCK) signal transduction (CLOCK) chromosome (CLOCK)
Anatomy Link Frequency
skeletal muscle 1
leg 1
CLOCK (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 7 97.56 Very High Very High Very High
Opioid 31 96.28 Very High Very High Very High
agonist 2 93.90 High High
Analgesic 24 88.24 High High
Enkephalin 2 81.80 Quite High
Neuropeptide 4 79.16 Quite High
Neurotransmitter 1 78.24 Quite High
Serotonin 4 60.80 Quite High
Eae 1 58.72 Quite High
Endogenous opioid 4 36.44 Quite Low
Disease Link Frequency Relevance Heat
Stress 10 61.52 Quite High
Pain 41 20.28 Low Low
Hyperalgesia 9 12.36 Low Low
Diabetes Mellitus 12 5.00 Very Low Very Low Very Low
Sleep Disorders 8 5.00 Very Low Very Low Very Low
Obesity 7 5.00 Very Low Very Low Very Low
Hypertrophy 6 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Coronary Artery Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-opioid receptor agonist fentanyl induces a phase shift in the circadian rhythm of hamsters independent of any behavioral effects of the opioid.8,9 We showed previously that fentanyl modifies the circadian pacemaker possibly via direct effects on SCN electrical activity and regulation of Per genes.8 This suggests that pathways regulating the circadian clock intersect directly or indirectly with pathways that express opioid receptors.
Regulation (regulating) of clock associated with agonist, opioid receptor and opioid
1) Confidence 0.21 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004635 Disease Relevance 0 Pain Relevance 0.84
The coordinated regulation of the circadian clock genes Cry1, Per2, and Bmal1 6 hours after RE and diurnal genes 18 hours after RE in the exercised leg suggest that RE may directly modulate circadian rhythms in human skeletal muscle.



Regulation (regulation) of clock in skeletal muscle
2) Confidence 0.14 Published 2003 Journal Genome Biol Section Abstract Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0
This large-scale expression analysis of acute RE and circadian gene regulation in hSkM suggests that RE can directly regulate circadian clock genes (Per2, Cry1, and Bmal1) and circadian output genes.
Regulation (regulate) of clock
3) Confidence 0.14 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0
Although the RE-induced changes of these circadian clock genes were modest in magnitude, they are statistically significant, coordinated, and precede RE-mediated changes in diurnal genes 18 hours after RE in the exercised leg.
Regulation (changes) of clock in leg
4) Confidence 0.14 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0.06 Pain Relevance 0

General Comments

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