INT175757

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.44
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PER2) protein binding transcription factor activity (PER2) cytoplasm (PER2)
signal transducer activity (PER2)
Anatomy Link Frequency
leg 1
PER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 16 98.32 Very High Very High Very High
Lamotrigine 23 5.00 Very Low Very Low Very Low
depression 11 5.00 Very Low Very Low Very Low
carbamazepine 9 5.00 Very Low Very Low Very Low
anticonvulsant 8 5.00 Very Low Very Low Very Low
Serotonin 8 5.00 Very Low Very Low Very Low
Gabapentin 7 5.00 Very Low Very Low Very Low
gABA 7 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 6 94.12 High High
Stress 16 84.44 Quite High
Thyroid Disease 1 76.32 Quite High
Apoptosis 9 67.60 Quite High
Manic Depressive Disorder 125 19.68 Low Low
Hypertrophy 10 14.08 Low Low
Diabetes Mellitus 20 5.00 Very Low Very Low Very Low
Depression 14 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Obesity 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among these, lithium upregulated the period homolog 2 (Per2), the secretogranin II (Scg2), the BDNF and the IMPA1 genes.
Positive_regulation (upregulated) of period homolog 2 associated with bdmf
1) Confidence 0.67 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.08 Pain Relevance 0.05
An interesting finding is that Per1 and Per2 are upregulated in the morning in hSkM (Figure 2), and downregulated in the morning in mSkM (Figure 3b).
Positive_regulation (upregulated) of Per2
2) Confidence 0.60 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0
In support of this, we found that three core circadian clock genes, Cry1, Per2, and Bmal1, were upregulated 6 hours after RE in the exercised leg (1.5-fold, 1.2-fold, and 1.2-fold, respectively; Figure 2b).
Positive_regulation (upregulated) of Per2 in leg
3) Confidence 0.60 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0.12 Pain Relevance 0
The significant upregulation of Per1 and Per2 in our diurnal comparison provided the first indication that the 608 genes that changed significantly with time contained known circadian-regulated genes.
Positive_regulation (upregulation) of Per2
4) Confidence 0.60 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0.25 Pain Relevance 0
Two clusters contained core circadian genes Per1 (Figure 6a) and Per2 (Figure 6b) which were upregulated at 0800 hours.
Positive_regulation (upregulated) of Per2
5) Confidence 0.53 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0
The Per2 cluster contained genes that were upregulated both at 0800 hours and in response to exercise (2000 hours + RE).



Positive_regulation (upregulated) of Per2
6) Confidence 0.41 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0

General Comments

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