INT175797

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Context Info
Confidence 0.07
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 6.52
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Hpse) extracellular region (Hpse) cell adhesion (Hpse)
nucleus (Hpse) carbohydrate metabolic process (Hpse) lysosome (Hpse)
Anatomy Link Frequency
sympathetic 4
peripheral nervous systems 1
parasympathetic 1
Hpse (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 90 99.72 Very High Very High Very High
Inflammatory response 26 94.08 High High
Inflammation 368 92.32 High High
vagus nerve 35 88.60 High High
rheumatoid arthritis 405 86.20 High High
medulla 5 82.52 Quite High
Spinal cord 30 76.72 Quite High
Catecholamine 25 63.80 Quite High
Central nervous system 105 60.40 Quite High
cytokine 158 54.24 Quite High
Disease Link Frequency Relevance Heat
Disease 158 99.80 Very High Very High Very High
Arthritis 90 99.72 Very High Very High Very High
Multiple Sclerosis 132 96.44 Very High Very High Very High
INFLAMMATION 391 93.72 High High
Stress 142 92.96 High High
Rheumatoid Arthritis 405 86.20 High High
Autoimmune Disease 21 80.56 Quite High
Obesity 5 58.56 Quite High
Sprains And Strains 27 58.08 Quite High
Injury 15 56.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of another indicator of HPA axis activity and regulation, glucocorticoid receptor (GR) expression, showed an increase in all groups of animals compared with their controls, 21 days after the onset of experiment (figure 1D; F: 14,74, dF: 7), indicating a normal regulation of the HPA axis.


Regulation (regulation) of Gene_expression (expression) of HPA
1) Confidence 0.07 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.23 Pain Relevance 0.07
Correlation between blunted HPA axis and disease
Regulation (blunted) of Gene_expression (axis) of HPA associated with disease
2) Confidence 0.03 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 0.95 Pain Relevance 0.27
Thus, animal models for arthritis have shown a role for the HPA axis, sympathetic, parasympathetic, and peripheral nervous systems.
Regulation (role) of Gene_expression (axis) of HPA in sympathetic associated with arthritis
3) Confidence 0.03 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 1.12 Pain Relevance 0.62
Correlation between blunted HPA axis and disease
Regulation (Correlation) of Gene_expression (axis) of HPA associated with disease
4) Confidence 0.03 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 1.00 Pain Relevance 0.30
Thus, animal models for arthritis have shown a role for the HPA axis, sympathetic, parasympathetic, and peripheral nervous systems.
Regulation (role) of in parasympathetic Gene_expression (axis) of HPA in sympathetic associated with arthritis
5) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 1.12 Pain Relevance 0.62
Thus, animal models for arthritis have shown a role for the HPA axis, sympathetic, parasympathetic, and peripheral nervous systems.
Regulation (role) of in peripheral nervous systems Gene_expression (axis) of HPA in sympathetic associated with arthritis
6) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 1.12 Pain Relevance 0.62

General Comments

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