INT1758

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1979
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 62
Total Number 63
Disease Relevance 31.72
Pain Relevance 13.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TIMP1) extracellular region (TIMP1)
Anatomy Link Frequency
keratinocytes 8
extracellular matrix 6
A549 6
kidney 5
macrophages 4
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 776 100.00 Very High Very High Very High
cytokine 673 100.00 Very High Very High Very High
chemokine 146 100.00 Very High Very High Very High
Osteoarthritis 111 100.00 Very High Very High Very High
Arthritis 28 99.92 Very High Very High Very High
rheumatoid arthritis 210 99.78 Very High Very High Very High
Inflammatory mediators 23 99.76 Very High Very High Very High
Snapping jaw 52 99.36 Very High Very High Very High
Inflammation 950 98.80 Very High Very High Very High
Endocannabinoid 10 98.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 201 100.00 Very High Very High Very High
Frailty 52 100.00 Very High Very High Very High
Major Depressive Disorder 50 100.00 Very High Very High Very High
Shock 15 99.98 Very High Very High Very High
Arthritis 44 99.92 Very High Very High Very High
Aggression 4 99.92 Very High Very High Very High
Renal Cancer 8 99.84 Very High Very High Very High
Disease 240 99.82 Very High Very High Very High
Rheumatoid Arthritis 212 99.78 Very High Very High Very High
Cirrhosis 61 99.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Uncoordinate regulation of collagenase, stromelysin, and tissue inhibitor of metalloproteinases genes by prostaglandin E2: selective enhancement of collagenase gene expression in human dermal fibroblasts in culture.
Positive_regulation (enhancement) of Gene_expression (expression) of collagenase in fibroblasts associated with metalloproteinase
1) Confidence 0.69 Published 1994 Journal J. Cell. Biochem. Section Title Doc Link 8014195 Disease Relevance 0.15 Pain Relevance 0.25
Although the effects of PGE2 did not potentiate those of IL-1 on collagenase gene expression in vitro, one could speculate that massive production of PGE2 by connective tissue cells in vivo in response to inflammatory mediators such as IL-1 or tumor necrosis factor-alpha, could lead to sustained expression of collagenase in connective tissue cells after clearance of the growth factors.
Positive_regulation (lead) of Gene_expression (expression) of collagenase in connective tissue associated with necrosis, inflammatory mediators and cancer
2) Confidence 0.69 Published 1994 Journal J. Cell. Biochem. Section Abstract Doc Link 8014195 Disease Relevance 0.43 Pain Relevance 0.22
Although the effects of PGE2 did not potentiate those of IL-1 on collagenase gene expression in vitro, one could speculate that massive production of PGE2 by connective tissue cells in vivo in response to inflammatory mediators such as IL-1 or tumor necrosis factor-alpha, could lead to sustained expression of collagenase in connective tissue cells after clearance of the growth factors.
Neg (not) Positive_regulation (potentiate) of Gene_expression (expression) of collagenase in connective tissue associated with necrosis, inflammatory mediators and cancer
3) Confidence 0.69 Published 1994 Journal J. Cell. Biochem. Section Abstract Doc Link 8014195 Disease Relevance 0.44 Pain Relevance 0.27
Additionally, dibutyryladenosine cyclic monophosphate (dBcAMP) restored collagenase synthesis in indomethacin-blocked cultures, indicating a PGE2-dependent generation of cAMP requirement for collagenase production similar to that demonstrated in experimental animals systems.
Positive_regulation (restored) of Gene_expression (synthesis) of collagenase
4) Confidence 0.68 Published 1987 Journal Cell. Immunol. Section Abstract Doc Link 3032463 Disease Relevance 0.22 Pain Relevance 0.25
The stimulation of TIMP-1 expression and suppression of cell invasion were reversed by pretreatment of cells with antagonists to CB1 or CB2 receptors, with inhibitors of MAPKs, or, in the case of MA, with an antagonist to TRPV1.
Positive_regulation (stimulation) of Gene_expression (expression) of TIMP-1
5) Confidence 0.67 Published 2008 Journal J. Natl. Cancer Inst. Section Body Doc Link 18159069 Disease Relevance 0 Pain Relevance 0
RESULTS: Without modifying migration, MA and THC caused a time- and concentration-dependent suppression of HeLa cell invasion through Matrigel that was accompanied by increased expression of TIMP-1.
Positive_regulation (increased) of Gene_expression (expression) of TIMP-1 in HeLa
6) Confidence 0.67 Published 2008 Journal J. Natl. Cancer Inst. Section Body Doc Link 18159069 Disease Relevance 0.05 Pain Relevance 0
Knockdown of cannabinoid-induced TIMP-1 expression by siRNA led to a reversal of the cannabinoid-elicited decrease in tumor cell invasiveness in HeLa, A549, and C33A cells.
Positive_regulation (-) of Gene_expression (expression) of TIMP-1 in A549
7) Confidence 0.67 Published 2008 Journal J. Natl. Cancer Inst. Section Body Doc Link 18159069 Disease Relevance 0 Pain Relevance 0
Increased expression of TIMP1 in RCC correlates with poor prognostic variable including shortened patient survival.
Positive_regulation (Increased) of Gene_expression (expression) of TIMP1 associated with renal cancer
8) Confidence 0.66 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.89 Pain Relevance 0.22
The paradoxical poor prognostic implication of TIMP overexpression documented in the literature complements the dual function of TIMPs and warrants further investigation [39].


Positive_regulation (overexpression) of Gene_expression (overexpression) of TIMP
9) Confidence 0.66 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.92 Pain Relevance 0.22
CONCLUSIONS: MMP-9, but not TIMP-1 or MMP-2 expression is increased in plaques causing acute coronary syndrome.


Positive_regulation (increased) of Gene_expression (expression) of TIMP-1 in plaques
10) Confidence 0.62 Published 2008 Journal Int. J. Cardiol. Section Body Doc Link 17706812 Disease Relevance 0.12 Pain Relevance 0
Overexpression of TIMP-1 and TIMP-2 is associated with inhibition of apoptosis and invasive tumour growth [18-20].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of TIMP-1 associated with cancer and apoptosis
11) Confidence 0.50 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 1.15 Pain Relevance 0.32
Additionally, dibutyryladenosine cyclic monophosphate (dBcAMP) restored collagenase synthesis in indomethacin-blocked cultures, indicating a PGE2-dependent generation of cAMP requirement for collagenase production similar to that demonstrated in experimental animals systems.
Positive_regulation (requirement) of Gene_expression (production) of collagenase
12) Confidence 0.49 Published 1987 Journal Cell. Immunol. Section Abstract Doc Link 3032463 Disease Relevance 0.23 Pain Relevance 0.27
AM; amniotic membrane, AMT; amniotic membrane transplantation, BCVA; the best corrected visual acuities, DLKP; deep lamellar keratoplasty, MMP; matrix metalloproteinase, TIMP; tissue inhibitor of metalloproteinase

Competing interests

Positive_regulation (matrix) of Gene_expression (membrane) of TIMP associated with metalloproteinase
13) Confidence 0.49 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1913057 Disease Relevance 0.65 Pain Relevance 0.19
1, TIMP-1 and TIMP-2 by ELISA assay
Positive_regulation (by) of Gene_expression (assay) of TIMP-1
14) Confidence 0.47 Published 2007 Journal Asian Spine Journal Section Body Doc Link PMC2857497 Disease Relevance 0 Pain Relevance 0.03
Knockdown of cannabinoid-induced TIMP-1 expression by siRNA led to a reversal of the cannabinoid-elicited decrease in tumor cell invasiveness in HeLa, A549, and C33A cells.
Positive_regulation (induced) of Gene_expression (expression) of TIMP-1 in A549
15) Confidence 0.45 Published 2008 Journal J. Natl. Cancer Inst. Section Body Doc Link 18159069 Disease Relevance 0 Pain Relevance 0
Especially, increased expressions of TIMP-1 and TIMP-2 have been implicated in increased fibrosis of a wide variety of human organs, including the liver, kidney, lungs, and heart, by reduced MMPs activities15-19.
Positive_regulation (increased) of Gene_expression (expressions) of TIMP-1 in kidney associated with fibrosis
16) Confidence 0.43 Published 2007 Journal Asian Spine Journal Section Body Doc Link PMC2857497 Disease Relevance 1.16 Pain Relevance 0.12
Furthermore, flurbiprofen was shown to induce the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1), an inhibitor of MMP-9.
Positive_regulation (induce) of Gene_expression (expression) of TIMP-1 associated with metalloproteinase
17) Confidence 0.42 Published 2009 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19501039 Disease Relevance 0.34 Pain Relevance 0.29
The beneficial effectsof this approach result from the presence of a rich extracellular matrix and collagen which provide a stromal substrate as in our case and anti-inflammatory properties arising from entrapment of inflammatory cells, the presence of various growth factors, inhibition of proteinase activity, and decrease of lipid peroxidation.[3] AM patch has also been reported to be effective in acute ulcerative and necrotizing herpetic stromal keratitis[4] due toreduction of gelatinolytic activity of MMP-9 and increased expression of TIMP-1.[5] These properties may have been responsible for the effective suppression of herpetic inflammation seen in this particular case.
Positive_regulation (increased) of Gene_expression (expression) of TIMP-1 in extracellular matrix associated with inflammation, keratitis and herpes simplex virus infection
18) Confidence 0.41 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1913057 Disease Relevance 1.11 Pain Relevance 0.17
This intervention increased the levels of EPA and DHA in the red blood cells in the actively treated group from 3.5±0.1% to 7.6±0.3%.
Positive_regulation (increased) of Gene_expression (levels) of EPA in red blood cells
19) Confidence 0.38 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993981 Disease Relevance 0.53 Pain Relevance 0
Northern blot analysis (Figure 7A) revealed an increase in TIMP-1 gene expression at 0.4 ?
Positive_regulation (increase) of Gene_expression (expression) of TIMP
20) Confidence 0.38 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox