INT17582

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Context Info
Confidence 0.53
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 6.11
Pain Relevance 4.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ELANE) extracellular region (ELANE) cytoplasm (ELANE)
Anatomy Link Frequency
leukocyte 10
neutrophils 6
neurons 4
blood 2
PGE1 2
ELANE (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 80 100.00 Very High Very High Very High
cINOD 41 99.98 Very High Very High Very High
rheumatoid arthritis 2 99.84 Very High Very High Very High
Locus ceruleus 3 99.42 Very High Very High Very High
Clonidine 75 99.12 Very High Very High Very High
anesthesia 6 98.40 Very High Very High Very High
agonist 19 97.94 Very High Very High Very High
lidocaine 4 97.44 Very High Very High Very High
nMDA receptor 3 96.68 Very High Very High Very High
Inflammation 91 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 98 99.86 Very High Very High Very High
Rheumatoid Arthritis 2 99.84 Very High Very High Very High
Pressure Volume 2 Under Development 2 99.20 Very High Very High Very High
Hypersensitivity 10 97.98 Very High Very High Very High
Asthma 8 97.70 Very High Very High Very High
Arthropathy 3 97.04 Very High Very High Very High
Thrombosis 3 96.20 Very High Very High Very High
Cirrhosis 26 94.28 High High
Arthritis 10 92.80 High High
Inflammatory Bowel Disease 6 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The anti-asthmatic/anti-allergic compounds azelastine, astemizole and oxatomide, and the 5-lipoxygenase inhibitor NDGA, were able to suppress the release of elastase from human leukocytes in concentrations between 10 and 100 microM.
Negative_regulation (suppress) of Localization (release) of elastase in leukocytes associated with asthma and hypersensitivity
1) Confidence 0.53 Published 1993 Journal Agents Actions Section Abstract Doc Link 8100381 Disease Relevance 0.62 Pain Relevance 0.42
Reduction in elastase release by azelastine, that accumulates in lung tissue during long-term treatment in animals, may contribute to its anti-inflammatory and anti-allergic effects which are thought to be central to its use in asthma therapy.
Negative_regulation (Reduction) of Localization (release) of elastase in lung associated with asthma, inflammation and hypersensitivity
2) Confidence 0.46 Published 1993 Journal Agents Actions Section Abstract Doc Link 8100381 Disease Relevance 0.81 Pain Relevance 0.43
Prednisolone and non-steroidal anti-inflammatory drugs inhibited elastase release at concentrations from 0.1 mM-0.1 nM.
Negative_regulation (inhibited) of Localization (release) of elastase associated with inflammation and cinod
3) Confidence 0.41 Published 1990 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1980289 Disease Relevance 0.26 Pain Relevance 0.22
Conclusion: CS, which is a major acidic lipid in the tracheobronchial epithelium, might function as an epithelial inhibitor toward neutrophil elastase secreted in response to several stimuli such as anesthesia.
Negative_regulation (inhibitor) of Localization (secreted) of elastase in epithelium associated with anesthesia
4) Confidence 0.37 Published 2006 Journal Transl Res Section Abstract Doc Link 16890150 Disease Relevance 0.08 Pain Relevance 0.44
Clonidine is an NE alpha-2-receptor agonist, which has been considered to act mainly on the autoreceptors of presynaptic noradrenergic neurons to reduce their release of NE.
Negative_regulation (reduce) of Localization (release) of NE in neurons associated with agonist and clonidine
5) Confidence 0.36 Published 2004 Journal Psychiatry Clin. Neurosci. Section Abstract Doc Link 15009817 Disease Relevance 0 Pain Relevance 0.70
The opposite actions of low and medium doses of clonidine on NREM-REM proportion may indicate that low-dose clonidine mainly affects the alpha-2-receptors on locus coeruleus-NE neurons presynaptically, reducing the release of NE, whereas medium-dose clonidine acts more post-synaptically.
Negative_regulation (reducing) of Localization (release) of NE in neurons associated with locus ceruleus and clonidine
6) Confidence 0.36 Published 2004 Journal Psychiatry Clin. Neurosci. Section Abstract Doc Link 15009817 Disease Relevance 0 Pain Relevance 0.99
At 120 minutes, lidocaine (100 mumol/L), which inhibits neutrophil activation, delayed release of lactoferrin (1.33 +/- 0.26 micrograms/mL) and markedly inhibited release of elastase (0.24 +/- 0.05 microgram/mL) but did not inhibit release of beta-TG antigen (5.66 micrograms/mL at 120 minutes).
Negative_regulation (inhibited) of Localization (release) of elastase in neutrophil associated with lidocaine
7) Confidence 0.33 Published 1987 Journal Blood Section Abstract Doc Link 2947645 Disease Relevance 0 Pain Relevance 0.15
PGE1 (0.3 mumol/L) inhibited significantly the release of beta-TG (0.31 microgram/mL) and elastase (0.52 +/- 0.11 microgram/mL) and attenuated the release of lactoferrin (1.57 +/- 0.45 micrograms/mL).
Negative_regulation (inhibited) of Localization (release) of elastase in PGE1
8) Confidence 0.33 Published 1987 Journal Blood Section Abstract Doc Link 2947645 Disease Relevance 0 Pain Relevance 0.09
Specifically, although NE potentiates processing in cortical areas, local NE release within the LC is autoinhibitory because of the noradrenergic action at presynaptic and dendritic ?
Negative_regulation (autoinhibitory) of Localization (release) of NE
9) Confidence 0.29 Published 2007 Journal Psychopharmacology (Berl) Section Body Doc Link PMC1915624 Disease Relevance 0 Pain Relevance 0
In addition, lysosomal enzyme secretion, such as elastase or myeloperoxidase as well as superoxide generation in human neutrophils were also reduced in a similar range.
Negative_regulation (reduced) of Localization (secretion) of elastase in neutrophils
10) Confidence 0.16 Published 2006 Journal Life Sci. Section Abstract Doc Link 16360707 Disease Relevance 0 Pain Relevance 0.16
We conclude that 30 ng.kg-1.min-1 infusion of PGE1 did not inhibit granulocyte elastase release from white blood cells, but has a tendency to inhibit postoperative platelet decrease.
Negative_regulation (inhibit) of Localization (release) of elastase in white blood cells
11) Confidence 0.12 Published 1991 Journal Masui Section Abstract Doc Link 1920794 Disease Relevance 0 Pain Relevance 0.08
We conclude that NPC 15669 is an effective inhibitor of antigen-induced leukocyte recruitment and elastase release and subsequent hypersecretion in airways.
Negative_regulation (inhibitor) of Localization (release) of elastase in leukocyte
12) Confidence 0.09 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943251 Disease Relevance 0.31 Pain Relevance 0.10
We conclude that NPC 15669 is an effective inhibitor of antigen-induced leukocyte recruitment and elastase release and subsequent hypersecretion in airways.
Negative_regulation (inhibitor) of Localization (release) of elastase in leukocyte
13) Confidence 0.06 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943251 Disease Relevance 0.31 Pain Relevance 0.10
Arnsten et al. suggest that stimulants act to enhance the release of and/or inhibit the reuptake of both DA and NE (norepinephrine) [54].
Negative_regulation (inhibit) of Localization (reuptake) of NE associated with dopamine
14) Confidence 0.04 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.19 Pain Relevance 0.36
Although the neutralization of the HLE could decrease the peri-operative blood loss, hypercoagulation can be induced, increasing the risk of vessel thrombosis and the consequent graft loss (31).
Negative_regulation (decrease) of Localization (neutralization) of HLE in blood associated with pressure volume 2 under development and thrombosis
15) Confidence 0.03 Published 2009 Journal Liver International Section Body Doc Link PMC2711256 Disease Relevance 1.10 Pain Relevance 0
It reduces the total white blood cell count in joint fluid, and it also inhibits leukocyte elastase, which is released in rheumatoid arthritis.
Negative_regulation (inhibits) of Localization (released) of leukocyte elastase in white blood cell associated with rheumatoid arthritis
16) Confidence 0.02 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.92 Pain Relevance 0.42
Moreover, GlcNAc also inhibits elastase activity and superoxide release from human polymorphonuclear leukocytes [108,109].

3.3.

Negative_regulation (inhibits) of Localization (release) of elastase in polymorphonuclear leukocytes
17) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2953398 Disease Relevance 1.51 Pain Relevance 0.23

General Comments

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