INT17584

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Context Info
Confidence 0.50
First Reported 1987
Last Reported 2010
Negated 7
Speculated 2
Reported most in Abstract
Documents 12
Total Number 14
Disease Relevance 4.69
Pain Relevance 10.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
ganglion 2
spinal 1
monocyte 1
RVM 1
salivary gland 1
tf (Mus musculus)
Pain Link Frequency Relevance Heat
tail-flick 59 100.00 Very High Very High Very High
narcan 6 100.00 Very High Very High Very High
ketamine 9 99.82 Very High Very High Very High
Rostral ventromedial medulla 5 99.80 Very High Very High Very High
intrathecal 8 99.64 Very High Very High Very High
antagonist 12 99.42 Very High Very High Very High
Morphine 27 99.32 Very High Very High Very High
Analgesic 7 99.08 Very High Very High Very High
Nerve growth factor 25 98.84 Very High Very High Very High
Opioid 10 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypotension 6 99.00 Very High Very High Very High
Melanoma 51 98.96 Very High Very High Very High
Urological Neuroanatomy 11 98.70 Very High Very High Very High
Cancer 63 98.60 Very High Very High Very High
Salivary Gland Disease 18 97.98 Very High Very High Very High
Ganglion Cysts 4 97.54 Very High Very High Very High
Cv Unclassified Under Development 6 96.56 Very High Very High Very High
Hypopituitarism 11 90.48 High High
Nociception 16 86.00 High High
Pressure Volume 2 Under Development 2 79.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal pretreatment with dextro-morphine (0.3-33 fmol), which injected alone did not affect the baseline TF latency, dose-dependently attenuated the TF inhibition produced by i.t.
Neg (not) Regulation (affect) of TF associated with tail-flick, morphine and intrathecal
1) Confidence 0.50 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15901793 Disease Relevance 0 Pain Relevance 2.00
The short-acting ganglion blocker trimethaphan (5 mg/kg, i.v.) closely mimicked the late hypotensive phase produced by 5-HT, but again resulted in no change in TF latency.
Neg (no) Regulation (change) of TF in ganglion associated with ganglion cysts, hypotension and tail-flick
2) Confidence 0.36 Published 1990 Journal Brain Res. Section Abstract Doc Link 2400935 Disease Relevance 0.88 Pain Relevance 0.38
We examined response of rats in the HP (55 degrees C, cutoff time 25 sec) and TF (cutoff time 5 sec) tests following administration of pentobarbitone, diazepam or pancuronium.
Spec (examined) Regulation (response) of TF associated with tail-flick
3) Confidence 0.26 Published 1991 Journal J Pharmacol Methods Section Abstract Doc Link 1921412 Disease Relevance 0 Pain Relevance 0.69
Pretreatment with the ganglion blocker chlorisondamine (2.5 mg/kg) abolished all depressor responses to 72 micrograms/kg 5-HT, but did not significantly affect the TF reflex.
Neg (not) Regulation (affect) of TF in ganglion associated with ganglion cysts and tail-flick
4) Confidence 0.25 Published 1990 Journal Brain Res. Section Abstract Doc Link 2400935 Disease Relevance 0.75 Pain Relevance 0.45
Opioid inhibition of the TF was also reduced, although baseline TF latency was unaffected, by RVM kynurenate.
Neg (unaffected) Regulation (unaffected) of TF in RVM associated with opioid and rostral ventromedial medulla
5) Confidence 0.13 Published 1999 Journal Pain Section Abstract Doc Link 10353493 Disease Relevance 0.19 Pain Relevance 1.57
Taken together these results show that Stx2, O157LPS and Stx2/LPS induce a significant increase in TF expression, predominantly on platelet-monocyte aggregates, that the combination of Stx2 and LPS had an additive effect on TF-expression on platelet-monocyte aggregates, and that O157LPS was slightly more potent than the other LPS serotypes.


Regulation (effect) of TF-expression in monocyte
6) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0 Pain Relevance 0
To investigate whether the developed tumors can mediate the altered expression of TFs in the salivary glands of tumor-bearing mice, we examined the NGF/Egr1 signal pathway because Egr1 was identified as an up-regulated TF in the salivary gland of melanoma-tumor mice.
Regulation (regulated) of TF in salivary gland associated with nerve growth factor, melanoma, salivary gland disease and cancer
7) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 1.11 Pain Relevance 0.29
These results strongly suggested that TFEB, a member of the MiTF family of bHLH-Zip transcription factors, was the only TF commonly altered by PAR1-AP, PAR2-AP, and PAR4-AP and therefore, occupied the center of Venn diagram (Figure 2).


Regulation (altered) of TF
8) Confidence 0.11 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.19 Pain Relevance 0.07
Pretreatment with either systemic or intrathecal ketamine did not alter TF facilitation or morphine-induced antinociception in spinal rats.
Neg (not) Regulation (alter) of TF in spinal associated with antinociception, ketamine, tail-flick, morphine and intrathecal
9) Confidence 0.08 Published 1994 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8029289 Disease Relevance 0.31 Pain Relevance 1.91
Changes in TF activity should alter transcription of target genes (a trans-effect; Fig. 1).
Regulation (Changes) of TF
10) Confidence 0.04 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.15 Pain Relevance 0
Microinjections of NAN-190, CPT and LY-278,584 alone into the VLO had no effect on the TF reflex.
Neg (no) Regulation (effect) of TF in VLO associated with tail-flick
11) Confidence 0.04 Published 2008 Journal Neuroscience Section Abstract Doc Link 18295406 Disease Relevance 0 Pain Relevance 0.56
Stimulation thresholds in the PAG or NRM for inhibition of the TF reflex were established and the effects of intrathecally administered phentolamine, yohimbine, prazosin, methysergide (15 micrograms initially, 30 micrograms cumulative) or naloxone (10 micrograms initially, 20 micrograms cumulative) on TF inhibitory thresholds determined.
Spec (determined) Regulation (effects) of TF associated with raphe magnus, narcan, tail-flick and central grey
12) Confidence 0.04 Published 1987 Journal Pain Section Abstract Doc Link 2892163 Disease Relevance 0.82 Pain Relevance 1.41
Microinjection of the 5-HT(3) receptor antagonist LY-278,584 (12 nmol) had no effect either on the TF reflex or on the Sm 5-HT-evoked inhibition.
Neg (no) Regulation (effect) of TF associated with antagonist and tail-flick
13) Confidence 0.02 Published 2005 Journal Brain Res. Section Abstract Doc Link 15869749 Disease Relevance 0.28 Pain Relevance 0.96
Figure 7 shows the identified putative regulation between TF families and transcriptional modules.
Regulation (regulation) of TF
14) Confidence 0.02 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2973961 Disease Relevance 0 Pain Relevance 0.11

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