INT175895

Context Info Confidence 0.37 First Reported 2004 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 3.23 Pain Relevance 0.05

plasma membrane (KRT1) cytoskeleton (KRT1)

Anatomy Link Frequency upper 1 KRT1 (Homo sapiens)

Pain Link Frequency Relevance Heat fibrosis 1 90.92 Pain 1 18.88 nud 1 17.88 antagonist 2 7.76 medulla 7 5.00 Inflammation 6 5.00 imagery 3 5.00 anesthesia 2 5.00 Chronic pancreatitis 1 5.00 palliative 1 5.00

Disease Link Frequency Relevance Heat Carcinoma 28 98.00 Cancer 112 94.96 Shock 4 94.48 Hemangioma 2 93.12 Apnoea 46 93.08 Necrosis 4 91.44 Cirrhosis 3 91.12 Fibrosis 1 90.92 Helminth Infection 1 87.88 Rhinitis 1 87.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Surprisingly, although the differentiated parts of the hair follicle, such as suprabasal outer root sheath, upper companion layer, upper inner root sheath or the hair fiber, are heavily keratinized structures, all of them are free of K1/K10.

Negative_regulation (free) of K1 in upper

1) Confidence 0.37 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.52 Pain Relevance 0

The fact that k1/k2 decreases from expiration to inspiration in normals indicates that phasic activity of UA dilators stabilizes the UA.

Negative_regulation (decreases) of k1

2) Confidence 0.12 Published 2005 Journal Respir Res Section Body Doc Link PMC1236961 Disease Relevance 0.18 Pain Relevance 0

In normals, k1/k2 significantly decreased from expiratory to inspiratory twitches (-11.1 ± 1.6 and -15.7 ± 1.0 cm H2O respectively, 95% CI 1.6–7.6, p < 0.01), with no difference between the two twitches timings in OSA subjects (-12.0 ± 1.1 and -10.9 ± 1.3 cm H2O respectively, 95% CI -3.2 to 1.1, p = 0.3).

Negative_regulation (decreased) of k1 associated with apnoea

3) Confidence 0.10 Published 2005 Journal Respir Res Section Body Doc Link PMC1236961 Disease Relevance 0.41 Pain Relevance 0

In scattered areas, cells were immunochemically positive for cytokeratin (CK) 7 and negative for CK 20.

Negative_regulation (positive) of cytokeratin

4) Confidence 0.02 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2246133 Disease Relevance 1.79 Pain Relevance 0.05

The presence of L3287del mutation in five affected members (II-1, II-2, III-2, III-4, and III-6) but its absence in eight unaffected members of PK002 family were demonstrated (Figure 5D).

Negative_regulation (presence) of II-1

5) Confidence 0.00 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC356914 Disease Relevance 0.34 Pain Relevance 0

General Comments

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