INT175895

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.23
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KRT1) cytoskeleton (KRT1)
Anatomy Link Frequency
upper 1
KRT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 1 90.92 High High
Pain 1 18.88 Low Low
nud 1 17.88 Low Low
antagonist 2 7.76 Low Low
medulla 7 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 28 98.00 Very High Very High Very High
Cancer 112 94.96 High High
Shock 4 94.48 High High
Hemangioma 2 93.12 High High
Apnoea 46 93.08 High High
Necrosis 4 91.44 High High
Cirrhosis 3 91.12 High High
Fibrosis 1 90.92 High High
Helminth Infection 1 87.88 High High
Rhinitis 1 87.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, although the differentiated parts of the hair follicle, such as suprabasal outer root sheath, upper companion layer, upper inner root sheath or the hair fiber, are heavily keratinized structures, all of them are free of K1/K10.
Negative_regulation (free) of K1 in upper
1) Confidence 0.37 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.52 Pain Relevance 0
The fact that k1/k2 decreases from expiration to inspiration in normals indicates that phasic activity of UA dilators stabilizes the UA.
Negative_regulation (decreases) of k1
2) Confidence 0.12 Published 2005 Journal Respir Res Section Body Doc Link PMC1236961 Disease Relevance 0.18 Pain Relevance 0
In normals, k1/k2 significantly decreased from expiratory to inspiratory twitches (-11.1 ± 1.6 and -15.7 ± 1.0 cm H2O respectively, 95% CI 1.6–7.6, p < 0.01), with no difference between the two twitches timings in OSA subjects (-12.0 ± 1.1 and -10.9 ± 1.3 cm H2O respectively, 95% CI -3.2 to 1.1, p = 0.3).
Negative_regulation (decreased) of k1 associated with apnoea
3) Confidence 0.10 Published 2005 Journal Respir Res Section Body Doc Link PMC1236961 Disease Relevance 0.41 Pain Relevance 0
In scattered areas, cells were immunochemically positive for cytokeratin (CK) 7 and negative for CK 20.
Negative_regulation (positive) of cytokeratin
4) Confidence 0.02 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2246133 Disease Relevance 1.79 Pain Relevance 0.05
The presence of L3287del mutation in five affected members (II-1, II-2, III-2, III-4, and III-6) but its absence in eight unaffected members of PK002 family were demonstrated (Figure 5D).


Negative_regulation (presence) of II-1
5) Confidence 0.00 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC356914 Disease Relevance 0.34 Pain Relevance 0

General Comments

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