INT1759

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Context Info
Confidence 0.77
First Reported 1979
Last Reported 2011
Negated 6
Speculated 4
Reported most in Abstract
Documents 267
Total Number 271
Disease Relevance 133.87
Pain Relevance 59.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TIMP1) extracellular region (TIMP1)
Anatomy Link Frequency
fibroblasts 13
tendon 9
macrophages 8
plaques 8
plasma 7
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 2687 100.00 Very High Very High Very High
cytokine 2272 100.00 Very High Very High Very High
chemokine 490 100.00 Very High Very High Very High
Pain 423 100.00 Very High Very High Very High
Inflammatory mediators 89 100.00 Very High Very High Very High
visual analogue scale 7 100.00 Very High Very High Very High
Arthritis 566 99.92 Very High Very High Very High
dexamethasone 110 99.84 Very High Very High Very High
rheumatoid arthritis 2295 99.62 Very High Very High Very High
Inflammation 3194 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3614 100.00 Very High Very High Very High
Adhesions 704 100.00 Very High Very High Very High
Pain 413 100.00 Very High Very High Very High
Glaucoma 261 100.00 Very High Very High Very High
Wound Healing 149 100.00 Very High Very High Very High
Hypertrophy 136 100.00 Very High Very High Very High
Arthritis 456 99.92 Very High Very High Very High
Cancer 1108 99.88 Very High Very High Very High
Inflammatory Bowel Disease 267 99.84 Very High Very High Very High
Renal Cancer 38 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, commonly used non-steroidal anti-inflammatory drugs (indomethacin, acetyl salicylic acid and ibuprofen), at doses which block prostaglandin synthesis in cultured fibroblasts, failed to counteract IL-1-induced collagenase and stromelysin gene expression, nor did they affect TIMP expression.
Gene_expression (expression) of TIMP in fibroblasts associated with inflammation and cinod
1) Confidence 0.77 Published 1994 Journal J. Cell. Biochem. Section Abstract Doc Link 8014195 Disease Relevance 0.16 Pain Relevance 0.27
Furthermore, commonly used non-steroidal anti-inflammatory drugs (indomethacin, acetyl salicylic acid and ibuprofen), at doses which block prostaglandin synthesis in cultured fibroblasts, failed to counteract IL-1-induced collagenase and stromelysin gene expression, nor did they affect TIMP expression.
Gene_expression (expression) of collagenase in fibroblasts associated with inflammation and cinod
2) Confidence 0.77 Published 1994 Journal J. Cell. Biochem. Section Abstract Doc Link 8014195 Disease Relevance 0.17 Pain Relevance 0.28
Exogenous PGE2 had no additive or synergistic effect with IL-1 on collagenase gene expression.
Gene_expression (expression) of collagenase in PGE2
3) Confidence 0.77 Published 1994 Journal J. Cell. Biochem. Section Abstract Doc Link 8014195 Disease Relevance 0.18 Pain Relevance 0.28
Although the effects of PGE2 did not potentiate those of IL-1 on collagenase gene expression in vitro, one could speculate that massive production of PGE2 by connective tissue cells in vivo in response to inflammatory mediators such as IL-1 or tumor necrosis factor-alpha, could lead to sustained expression of collagenase in connective tissue cells after clearance of the growth factors.
Gene_expression (expression) of collagenase in connective tissue associated with necrosis, inflammatory mediators and cancer
4) Confidence 0.77 Published 1994 Journal J. Cell. Biochem. Section Abstract Doc Link 8014195 Disease Relevance 0.43 Pain Relevance 0.27
Uncoordinate regulation of collagenase, stromelysin, and tissue inhibitor of metalloproteinases genes by prostaglandin E2: selective enhancement of collagenase gene expression in human dermal fibroblasts in culture.
Gene_expression (expression) of collagenase in fibroblasts associated with metalloproteinase
5) Confidence 0.77 Published 1994 Journal J. Cell. Biochem. Section Title Doc Link 8014195 Disease Relevance 0.15 Pain Relevance 0.25
Incubation of confluent fibroblast cultures with varying concentrations (0.01-1.0 microgram/ml) of PGE2 led to a dose-dependent elevation of collagenase mRNA steady-state levels, the promoter activity, and the secretion of the protein, whereas relatively little effect was observed on stromelysin and TIMP gene expression.
Gene_expression (expression) of TIMP in PGE2
6) Confidence 0.77 Published 1994 Journal J. Cell. Biochem. Section Abstract Doc Link 8014195 Disease Relevance 0.17 Pain Relevance 0.27
Although the effects of PGE2 did not potentiate those of IL-1 on collagenase gene expression in vitro, one could speculate that massive production of PGE2 by connective tissue cells in vivo in response to inflammatory mediators such as IL-1 or tumor necrosis factor-alpha, could lead to sustained expression of collagenase in connective tissue cells after clearance of the growth factors.
Gene_expression (expression) of collagenase in connective tissue associated with necrosis, inflammatory mediators and cancer
7) Confidence 0.77 Published 1994 Journal J. Cell. Biochem. Section Abstract Doc Link 8014195 Disease Relevance 0.43 Pain Relevance 0.22
Collagenase was detected in the culture media within the first 24 hr of culture after activation with peak production at 48 hr.
Gene_expression (detected) of Collagenase
8) Confidence 0.76 Published 1987 Journal Cell. Immunol. Section Abstract Doc Link 3032463 Disease Relevance 0.20 Pain Relevance 0.17
Dexamethasone, colchicine or retinoic acid all inhibited collagenase synthesis by monocytes in a dose-dependent manner although the effect of these drugs on monocyte PGE2 synthesis differed.
Gene_expression (synthesis) of collagenase in monocytes associated with dexamethasone
9) Confidence 0.76 Published 1987 Journal Cell. Immunol. Section Abstract Doc Link 3032463 Disease Relevance 0.17 Pain Relevance 0.32
Human monocytes, isolated in large quantities by counterflow centrifugal elutriation, were shown to produce substantial amounts of collagenase when stimulated by concanavalin A (Con A) and to a lesser extent with lipopolysaccharide, while unstimulated monocyte cultures produced negligible collagenase.
Gene_expression (produce) of collagenase in monocytes
10) Confidence 0.76 Published 1987 Journal Cell. Immunol. Section Abstract Doc Link 3032463 Disease Relevance 0.16 Pain Relevance 0.12
Inhibition of collagenase synthesis by dexamethasone, but not colchicine or retinoic acid, could be reversed by PGE2 or phospholipase A2.
Gene_expression (synthesis) of collagenase associated with dexamethasone
11) Confidence 0.76 Published 1987 Journal Cell. Immunol. Section Abstract Doc Link 3032463 Disease Relevance 0.15 Pain Relevance 0.37
Additionally, dibutyryladenosine cyclic monophosphate (dBcAMP) restored collagenase synthesis in indomethacin-blocked cultures, indicating a PGE2-dependent generation of cAMP requirement for collagenase production similar to that demonstrated in experimental animals systems.
Gene_expression (production) of collagenase
12) Confidence 0.76 Published 1987 Journal Cell. Immunol. Section Abstract Doc Link 3032463 Disease Relevance 0.23 Pain Relevance 0.27
Human monocytes, isolated in large quantities by counterflow centrifugal elutriation, were shown to produce substantial amounts of collagenase when stimulated by concanavalin A (Con A) and to a lesser extent with lipopolysaccharide, while unstimulated monocyte cultures produced negligible collagenase.
Gene_expression (produced) of collagenase in monocytes
13) Confidence 0.76 Published 1987 Journal Cell. Immunol. Section Abstract Doc Link 3032463 Disease Relevance 0.16 Pain Relevance 0.12
Since tissue macrophages are derived from circulating peripheral blood monocytes, we used these less-differentiated, more readily available cells to examine the production and regulation of collagenase.
Spec (examine) Gene_expression (production) of collagenase in monocytes
14) Confidence 0.76 Published 1987 Journal Cell. Immunol. Section Abstract Doc Link 3032463 Disease Relevance 0.17 Pain Relevance 0.12
Additionally, dibutyryladenosine cyclic monophosphate (dBcAMP) restored collagenase synthesis in indomethacin-blocked cultures, indicating a PGE2-dependent generation of cAMP requirement for collagenase production similar to that demonstrated in experimental animals systems.
Gene_expression (synthesis) of collagenase
15) Confidence 0.76 Published 1987 Journal Cell. Immunol. Section Abstract Doc Link 3032463 Disease Relevance 0.22 Pain Relevance 0.25
These findings provide insight into the intracellular events regulating monocyte collagenase synthesis and also implicate monocytes as a target of anti-inflammatory agents which ameliorate connective tissue degradation associated with chronic inflammatory lesions.
Gene_expression (synthesis) of collagenase in connective tissue associated with inflammation
16) Confidence 0.76 Published 1987 Journal Cell. Immunol. Section Abstract Doc Link 3032463 Disease Relevance 0.34 Pain Relevance 0.37
Since VEGF has the potential to stimulate the expression of matrix metalloproteinases and inhibits the expression of tissue inhibitors of matrix metalloproteinases (TIMP) in various cell types this cytokine might play a significant role in the pathogenetic processes during degenerative tendon disease.
Gene_expression (expression) of TIMP in tendon associated with metalloproteinase, disease and cytokine
17) Confidence 0.75 Published 2005 Journal Orthopade Section Abstract Doc Link 15926081 Disease Relevance 0.58 Pain Relevance 0.49
In the majority of synovial fluid samples, angiogenin (Ang), fibroblast growth factor (FGF)-9, insulin-like growth factor-binding protein (IGFBP)-3, interleukin (IL)-1alpha, IL-1beta, IL-8, inducible protein (IP)-10, macrophage inflammatory protein (MIP)-1beta, osteoprotegerin (OPG), transforming growth factor (TGF)-beta2, tissue inhibitor of metalloproteinase (TIMP)-1, TIMP-2, tumour necrosis factor (TNF)-beta and vascular endothelial growth factor (VEGF) were detectable.
Gene_expression (detectable) of TIMP in fibroblast
18) Confidence 0.75 Published 2006 Journal Dentomaxillofac Radiol Section Body Doc Link 17082335 Disease Relevance 0.14 Pain Relevance 0
The value of MMPs and TIMPs expression in bladder tissue
Gene_expression (expression) of TIMP in bladder associated with metalloproteinase
19) Confidence 0.75 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.66 Pain Relevance 0.14
CONCLUSION: Increased expression of TIMP-1 mediates an anti-invasive effect of cannabinoids.
Gene_expression (expression) of TIMP-1
20) Confidence 0.75 Published 2008 Journal J. Natl. Cancer Inst. Section Body Doc Link 18159069 Disease Relevance 0 Pain Relevance 0

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