INT175904

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.05
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RAC1) cell motility (RAC1) cell adhesion (RAC1)
plasma membrane (RAC1) enzyme binding (RAC1) GTPase activity (RAC1)
Anatomy Link Frequency
upper limb 1
nucleus 1
levator palpebrae superioris 1
RAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 89 99.08 Very High Very High Very High
Chronic pancreatitis 2 96.88 Very High Very High Very High
Botox 114 96.24 Very High Very High Very High
imagery 45 93.52 High High
Multiple sclerosis 3 87.76 High High
cINOD 2 77.60 Quite High
Arthritis 12 71.76 Quite High
cytokine 27 67.92 Quite High
transcutaneous nerve stimulation 2 63.64 Quite High
Acupuncture 2 60.56 Quite High
Disease Link Frequency Relevance Heat
Spasticity 95 99.80 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 11 99.44 Very High Very High Very High
Pain 68 99.08 Very High Very High Very High
Myasthenia Gravis 6 98.32 Very High Very High Very High
Metastasis 41 98.20 Very High Very High Very High
Coagulation Disorder 5 97.56 Very High Very High Very High
Pancreatitis 2 96.88 Very High Very High Very High
Hypersensitivity 5 95.44 Very High Very High Very High
Athletic Injuries 1 92.68 High High
Cancer 175 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This has provided limited evidence to support continued use of botulinum toxin for spasticity reduction.
Localization (use) of botulinum toxin associated with spasticity
1) Confidence 0.41 Published 2008 Journal Trials Section Body Doc Link PMC2611962 Disease Relevance 0.57 Pain Relevance 0
Use of botulinum toxin to the upper limb in the previous three months.

?

Localization (Use) of botulinum toxin in upper limb
2) Confidence 0.41 Published 2008 Journal Trials Section Body Doc Link PMC2611962 Disease Relevance 1.44 Pain Relevance 0.17
For monitoring localized small Rho GTPase activities (Cdc42, Rac1, RhoA) in cells, YFP-Raichu-CFP probes have been reported previously [70].
Localization (localized) of Rac1
3) Confidence 0.40 Published 2009 Journal Target Oncol Section Body Doc Link PMC2778706 Disease Relevance 0.09 Pain Relevance 0.05
Transient ptosis is the most frequently reported complication and has been reported in the literature in approximately 5% of patients.40,44 Ptosis of the eyelid results from migration of the botulinum toxin to the levator palpebrae superioris muscle.
Localization (migration) of botulinum toxin in levator palpebrae superioris associated with ocular toxicity (including many sub-types)
4) Confidence 0.29 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2943226 Disease Relevance 0.75 Pain Relevance 0
In each of these studies RhoA, Rac1 and Cdc42 were not significantly altered nor were they associated with aggressive or metastatic disease.
Neg (not) Localization (altered) of Rac1 associated with metastasis
5) Confidence 0.27 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.49 Pain Relevance 0.19
The activity of Rac1 leads to STAT3 translocation to the nucleus coincident with STAT3-dependent gene expression [72].
Localization (translocation) of Rac1 in nucleus
6) Confidence 0.24 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.07 Pain Relevance 0.03
Use of botulinum toxin-A for musculoskeletal pain in patients with whiplash associated disorders [ISRCTN68653575]

Background

Localization (Use) of botulinum toxin associated with pain
7) Confidence 0.06 Published 2004 Journal BMC Musculoskelet Disord Section Title Doc Link PMC356919 Disease Relevance 0.65 Pain Relevance 0.42

General Comments

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