INT17592

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 3.54
Pain Relevance 10.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
spinal cord 6
hypothalamus 6
dorsal 5
neurons 4
cell groups 2
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 7 100.00 Very High Very High Very High
anesthesia 6 100.00 Very High Very High Very High
narcan 15 99.76 Very High Very High Very High
Morphine 25 99.68 Very High Very High Very High
depression 1 99.68 Very High Very High Very High
Spinal cord 13 99.52 Very High Very High Very High
dexamethasone 5 99.50 Very High Very High Very High
GABAergic 2 99.50 Very High Very High Very High
withdrawal 28 99.32 Very High Very High Very High
amygdala 12 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Toxocariasis 1 100.00 Very High Very High Very High
Depression 6 99.68 Very High Very High Very High
Post Operative Pain 2 99.24 Very High Very High Very High
Opiate Addiction 1 99.14 Very High Very High Very High
Syndrome 2 99.04 Very High Very High Very High
Injury 3 98.80 Very High Very High Very High
Urological Neuroanatomy 10 97.44 Very High Very High Very High
Frailty 8 96.76 Very High Very High Very High
Neuropathic Pain 1 96.38 Very High Very High Very High
Pain 11 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of c-fos immunoreactivity in tyrosine hydroxylase and phenylethanolamine-N-methyltransferase immunoreactive neurons of the medulla oblongata of the rat after phosphate-buffered saline load in the urethane-anaesthetized rat.
Positive_regulation (Induction) of Regulation (immunoreactivity) of c-fos in neurons associated with medulla and anesthesia
1) Confidence 0.67 Published 1993 Journal Brain Res. Section Title Doc Link 8095432 Disease Relevance 0 Pain Relevance 0.29
The present results indicate that c-fos and c-jun mRNA levels are both increased in the adrenal gland after capsaicin treatment, although the time course, magnitude and regional distribution of these increases differed for the two mRNAs.
Positive_regulation (increased) of Regulation (levels) of c-fos in adrenal gland associated with qutenza
2) Confidence 0.49 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1922926 Disease Relevance 0 Pain Relevance 0.55
Naloxone treatment in naive rats induced a slight increase in c-Fos immunoreactivity in the central amygdaloid nucleus, the lateral bed nucleus of the stria terminalis and the interstitial nucleus of the posterior limb of the anterior commissure.
Positive_regulation (increase) of Regulation (immunoreactivity) of c-Fos in limb associated with narcan
3) Confidence 0.49 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12956728 Disease Relevance 0 Pain Relevance 0.84
The largest and most significant increase in Fos immunoreactivity was found in the ventrolateral column (especially in its caudal part), whereas only a moderate increase was found in the lateral column.
Positive_regulation (increase) of Regulation (immunoreactivity) of Fos in lateral column
4) Confidence 0.47 Published 1997 Journal Neuroscience Section Abstract Doc Link 9135098 Disease Relevance 0.85 Pain Relevance 0.29
Formalin (2.5%), injected subcutaneously into the rat hindpaw, increased Fos immunoreactivity in laminae I-II, III-IV, and V-VI of the dorsal L5 spinal cord.
Positive_regulation (increased) of Regulation (immunoreactivity) of Fos in dorsal associated with spinal cord
5) Confidence 0.47 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 11812713 Disease Relevance 0 Pain Relevance 0.30
However, when opioid withdrawal was precipitated with naloxone a dramatic increase in Fos immunoreactivity was observed in the parvocellular division of the paraventricular nucleus and in the supraoptic nucleus.
Positive_regulation (increase) of Regulation (immunoreactivity) of Fos in supraoptic nucleus associated with narcan, withdrawal and opioid
6) Confidence 0.47 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11698063 Disease Relevance 0.10 Pain Relevance 0.90
Fos immunoreactivity in the PVN and also in the nucleus tractus solitarius (NTS)-A2 and ventrolateral medulla (VLM)-A1 cell groups, which project to the PVN, increased during morphine withdrawal.
Positive_regulation (increased) of Regulation (immunoreactivity) of Fos in cell groups associated with medulla, toxocariasis, withdrawal and morphine
7) Confidence 0.47 Published 2002 Journal J. Neurochem. Section Abstract Doc Link 12358736 Disease Relevance 0.17 Pain Relevance 1.26
However, despite the known selectivity of Tyr-W-MIF-1 for mu receptors, FOS immunoreactivity was also induced in nuclei of the amygdala, hypothalamus, and thalamus, where concentrations of kappa receptors were high but those of mu and delta receptors were not detected.
Positive_regulation (induced) of Regulation (immunoreactivity) of FOS in hypothalamus associated with thalamus and amygdala
8) Confidence 0.47 Published 1994 Journal Peptides Section Abstract Doc Link 7700853 Disease Relevance 0 Pain Relevance 0.59
Pre- versus postinjury effects of intravenous GABAergic anesthetics on formalin-induced Fos immunoreactivity in the rat spinal cord.
Positive_regulation (induced) of Regulation (immunoreactivity) of Fos in spinal cord associated with analgesic, gabaergic and spinal cord
9) Confidence 0.46 Published 1999 Journal Anesth. Analg. Section Title Doc Link 9972767 Disease Relevance 0 Pain Relevance 0.29
Fos immunoreactivity was induced particularly in the superficial layers of the spinal cord 2 h after surgery.
Positive_regulation (induced) of Regulation (immunoreactivity) of Fos in spinal cord associated with spinal cord
10) Confidence 0.46 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12749994 Disease Relevance 0.17 Pain Relevance 0.88
Exposure of animals to an ambient temperature of 5 degrees C induced Fos immunoreactivity in the magnocellular paraventricular nucleus (mPVN) and the dorsomedial region of the hypothalamus (DMH).
Positive_regulation (induced) of Regulation (immunoreactivity) of Fos in DMH
11) Confidence 0.46 Published 2002 Journal Brain Res. Section Abstract Doc Link 11931855 Disease Relevance 0.28 Pain Relevance 0.13
RESULTS: Uterine cervical distension significantly increased cFos immunoreactivity in the spinal cord from T12 to L2, with most cFos expression in the deep dorsal and central canal regions.
Positive_regulation (increased) of Regulation (immunoreactivity) of cFos in dorsal
12) Confidence 0.45 Published 2003 Journal Anesthesiology Section Body Doc Link 12826861 Disease Relevance 0 Pain Relevance 0
Alterations in PD, c-fos, and SERT expression could contribute to the depression-like syndrome associated with psychostimulant withdrawal.
Positive_regulation (contribute) of Regulation (Alterations) of c-fos associated with depression, syndrome and withdrawal
13) Confidence 0.45 Published 2009 Journal Synapse Section Abstract Doc Link 19116947 Disease Relevance 0.35 Pain Relevance 0.67
Chronic neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve decreased the number of c-Fos positive cells following acute mechanical stimulation in the dAM and FU nuclei, and increased c-Fos immunoreactivity in the ventral medial (vAM) aspect of the BST.
Positive_regulation (increased) of Regulation (immunoreactivity) of c-Fos in ventral associated with eae, injury, neuropathic pain and sciatic nerve
14) Confidence 0.45 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18164529 Disease Relevance 0.57 Pain Relevance 0.62
All drugs produced marked reductions of formalin-induced c-Fos and Zif/268 immunoreactivity in laminae I and II, and laminae V and VI in the rat lumbar spinal cord.
Positive_regulation (induced) of Regulation (immunoreactivity) of c-Fos in spinal cord associated with spinal cord
15) Confidence 0.45 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12223232 Disease Relevance 0.07 Pain Relevance 0.57
Central administration of IL-1 beta strongly increases c-Fos immunoreactivity in the PVN, mainly within CRF neurons.
Positive_regulation (increases) of Regulation (immunoreactivity) of c-Fos in PVN
16) Confidence 0.45 Published 1993 Journal Ciba Found. Symp. Section Abstract Doc Link 8491087 Disease Relevance 0 Pain Relevance 0.17
DEX treatment significantly enhanced the number of Fos positive nuclei in Laminae I-III by 4 h after transection, although the response was not maintained by intensive steroid treatment when tested at 48 h after SCI.
Positive_regulation (enhanced) of Regulation (number) of Fos associated with frailty and dexamethasone
17) Confidence 0.44 Published 2001 Journal Brain Res. Section Abstract Doc Link 11532430 Disease Relevance 0.82 Pain Relevance 0.41
About 40%-50% of NADPH-diaphorase-positive neurons exhibited Fos immunoreactivity after injection of lipopolysaccharide or hypertonic saline, while only 10%-15% of these neurons expressed Fos in response to immobilization or pain.
Positive_regulation (exhibited) of Regulation (immunoreactivity) of Fos in neurons associated with pain
18) Confidence 0.35 Published 1996 Journal J. Chem. Neuroanat. Section Abstract Doc Link 8951594 Disease Relevance 0.17 Pain Relevance 0.14
However, despite the known selectivity of Tyr-W-MIF-1 for mu receptors, FOS immunoreactivity was also induced in nuclei of the amygdala, hypothalamus, and thalamus, where concentrations of kappa receptors were high but those of mu and delta receptors were not detected.
Positive_regulation (induced) of in amygdala Regulation (immunoreactivity) of FOS in hypothalamus associated with thalamus and amygdala
19) Confidence 0.16 Published 1994 Journal Peptides Section Abstract Doc Link 7700853 Disease Relevance 0 Pain Relevance 0.59
However, despite the known selectivity of Tyr-W-MIF-1 for mu receptors, FOS immunoreactivity was also induced in nuclei of the amygdala, hypothalamus, and thalamus, where concentrations of kappa receptors were high but those of mu and delta receptors were not detected.
Positive_regulation (induced) of in thalamus Regulation (immunoreactivity) of FOS in hypothalamus associated with thalamus and amygdala
20) Confidence 0.16 Published 1994 Journal Peptides Section Abstract Doc Link 7700853 Disease Relevance 0 Pain Relevance 0.59

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