INT17593

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 1991
Last Reported 2008
Negated 12
Speculated 5
Reported most in Abstract
Documents 37
Total Number 42
Disease Relevance 5.50
Pain Relevance 14.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
hippocampus 5
brain 3
dorsal horn 2
adrenal medulla 2
cortex 2
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 57 100.00 Very High Very High Very High
Morphine 31 100.00 Very High Very High Very High
tolerance 5 100.00 Very High Very High Very High
Hippocampus 27 99.96 Very High Very High Very High
qutenza 27 99.82 Very High Very High Very High
Thalamus 9 99.78 Very High Very High Very High
Opioid 28 99.56 Very High Very High Very High
Dynorphin 12 99.12 Very High Very High Very High
narcan 6 99.06 Very High Very High Very High
Neurotransmitter 6 98.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 13 96.40 Very High Very High Very High
Cancer 13 96.40 Very High Very High Very High
Temporomandibular Joint Syndrome 4 96.32 Very High Very High Very High
Hyperalgesia 6 95.20 Very High Very High Very High
Renal Disease 6 94.84 High High
Anxiety Disorder 20 93.16 High High
Diabetes Mellitus 3 89.08 High High
Thyroid Neoplasm 18 85.68 High High
Neuropathic Pain 2 85.48 High High
Renal Failure 4 84.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, kainate induction of preproenkephalin and preprodynorphin mRNAs was examined; these genes have been shown to be induced by kainate and have been suggested to be targets of AP-1 regulation in adult rat hippocampus.
Regulation (regulation) of AP-1 in hippocampus associated with hippocampus
1) Confidence 0.60 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8294905 Disease Relevance 0.10 Pain Relevance 0.42
Capsaicin also induced an increase in c-fos mRNA levels in all 3 cortical layers, especially in the zona glomerulosa, whereas only small changes in c-jun mRNA levels were seen in zona fasciculata and reticulata.
Regulation (changes) of c-jun mRNA associated with qutenza
2) Confidence 0.53 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1922926 Disease Relevance 0 Pain Relevance 0.56
Neuronal regulation of c-fos, c-jun, and junB immediate-early genes in rat adrenal medulla.
Regulation (regulation) of c-jun in adrenal medulla associated with medulla and qutenza
3) Confidence 0.51 Published 1995 Journal J. Neurosci. Section Title Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.44
We have applied in situ hybridization histochemistry, Northern analysis, and immunocytochemistry to study the regulation of the immediate-early gene (IEG) c-fos, c-jun, and junB mRNAs and the respective proteins in the rat adrenal medulla.
Regulation (regulation) of c-jun in adrenal medulla associated with medulla
4) Confidence 0.51 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.26
The effect of phorbol-12-myristate-13-acetate (PMA) on the regulation of proenkephalin (proENK) mRNA level, ENKCRE-2 or AP-1 DNA binding activity, and the mRNA and protein levels of proto-oncogenes (c-fos, fra-1, and c-jun) in primary cultured rat astrocytes were studied.
Regulation (regulation) of AP-1 in astrocytes
5) Confidence 0.49 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555062 Disease Relevance 0 Pain Relevance 0
However, in the medial thalamus it increased c-Jun and reduced the basal expression of JunD, whereas in the lateral thalamus it had no effect on c-Jun but again reduced the basal expression of JunD.
Neg (no) Regulation (effect) of c-Jun in medial associated with thalamus
6) Confidence 0.48 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0 Pain Relevance 0.75
In the rat hippocampus, jun, c-fos, and fos-related antigen immunoreactivity, AP-1 DNA binding, and opioid peptide gene expression were examined after kainate treatment to determine whether the induction and DNA binding of AP-1 transcription factors are correlated with the expression of the opioid peptide genes.
Regulation (immunoreactivity) of jun in hippocampus associated with hippocampus and opioid
7) Confidence 0.45 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8417141 Disease Relevance 0 Pain Relevance 0.38
The data show that a single dose of caffeine induces a temporally and spatially characteristic pattern of c-fos, c-jun, and junB induction, followed by changes in AP-1 and preproenkephalin mRNA.
Regulation (changes) of AP-1
8) Confidence 0.43 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7751931 Disease Relevance 0 Pain Relevance 0.11
Eight hours following noxious heat plus morphine application we did not detect noxious evoked immunoreactivity for c-Fos, Krox-24, c-Jun and Jun B, while there was residual labelling for Fos B in the superficial dorsal horn and for Jun D in laminae I-VII and X of the spinal cord.
Neg (not) Regulation (immunoreactivity) of Jun in dorsal horn associated with dorsal horn, spinal cord and morphine
9) Confidence 0.42 Published 1994 Journal Neuroscience Section Abstract Doc Link 8152542 Disease Relevance 0 Pain Relevance 1.15
Furthermore, our present results suggest that the transcription factors, c-fos, c-jun and activator protein-1 complex may be involved in the process of inducing the hippocampal proenkephalin gene, while these factors might be differently involved in regulation of prodynorphin gene expression.
Regulation (involved) of activator protein-1
10) Confidence 0.41 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477937 Disease Relevance 0.32 Pain Relevance 0.11
It was also found that chronic ethanol treatment and its withdrawal (24 h) had no effect on AP-1 DNA-binding activity in the rat cortex.
Neg (no) Regulation (effect) of AP-1 in cortex associated with withdrawal
11) Confidence 0.41 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918601 Disease Relevance 0.24 Pain Relevance 0.45
This investigation examined the effects of acute and chronic ethanol exposure and its withdrawal on the cAMP-responsive element binding protein (CREB) and the activator protein-1 (AP-1) gene transcription factors in the rat brain.
Spec (examined) Regulation (effects) of AP-1 in brain associated with withdrawal
12) Confidence 0.41 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918601 Disease Relevance 0.19 Pain Relevance 0.21
This investigation examined the effects of acute and chronic ethanol exposure and its withdrawal on the cAMP-responsive element binding protein (CREB) and the activator protein-1 (AP-1) gene transcription factors in the rat brain.
Spec (examined) Regulation (effects) of activator protein-1 in brain associated with withdrawal
13) Confidence 0.41 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918601 Disease Relevance 0.19 Pain Relevance 0.20
It was observed that acute ethanol treatment and its withdrawal (24 h) had no effect on CRE- or AP-1 DNA-binding activities in the rat cortex as determined by the electrophoretic gel-mobility shift assay.
Neg (no) Regulation (effect) of AP-1 in cortex associated with withdrawal
14) Confidence 0.41 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918601 Disease Relevance 0.26 Pain Relevance 0.40
However, acute naloxone-precipitated withdrawal did not significantly change AP-1 or NF-kappa B activity.
Neg (not) Regulation (change) of AP-1 associated with narcan and withdrawal
15) Confidence 0.39 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8843097 Disease Relevance 0 Pain Relevance 0.40
The present results indicate that c-fos and c-jun mRNA levels are both increased in the adrenal gland after capsaicin treatment, although the time course, magnitude and regional distribution of these increases differed for the two mRNAs.
Regulation (levels) of c-jun mRNA in adrenal gland associated with qutenza
16) Confidence 0.39 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1922926 Disease Relevance 0 Pain Relevance 0.54
The present experiments evaluated the possible role of two families of immediate-early gene (IEG) proteins, Fos and Jun, in the induction of DYN biosynthesis following repeated treatment with DA agonists.
Spec (possible) Regulation (role) of Jun associated with dopamine, dynorphin and agonist
17) Confidence 0.39 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7914658 Disease Relevance 0 Pain Relevance 0.79
In this paper, we attempted to investigate whether the transcription factors regulating the gene expression of c-fos and nNOS, including activator protein-1 (AP-1), nuclear factor kappa B (NF-kappa B), and octamer factors (Oct), are activated by CFA during the development of hyperalgesia.
Spec (whether) Regulation (regulating) of activator protein-1 associated with hyperalgesia and freund adjuvant
18) Confidence 0.38 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10940358 Disease Relevance 0.26 Pain Relevance 0.56
The inhibitory effect of c-Fos antibody electroporation in the regulation of AP-1 promoter activity was assessed according to the relative luciferase activity.
Regulation (regulation) of AP-1
19) Confidence 0.38 Published 2003 Journal Anesthesiology Section Body Doc Link 14508329 Disease Relevance 0.09 Pain Relevance 0
Although stimulation of both nicotinic and muscarinic cholinergic receptors may mediate the induction of these IEGs, it is possible that also another neurotransmitter(s), in addition to ACh, released from splanchnic nerve terminals is involved in the regulation of their expression, especially of c-jun and junB.
Regulation (regulation) of c-jun in nerve associated with neurotransmitter
20) Confidence 0.38 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.41

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox