INT175947

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Context Info
Confidence 0.01
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.12
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CASP8) cytoplasm (CASP8) cell-cell signaling (TNFSF10)
cytosol (CASP8) peptidase activity (CASP8) extracellular space (TNFSF10)
TNFSF10 (Homo sapiens)
CASP8 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 80.32 Quite High
rheumatoid arthritis 19 70.40 Quite High
methotrexate 5 52.68 Quite High
Inflammation 8 15.12 Low Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Rheumatism 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 53 99.64 Very High Very High Very High
Death 4 98.66 Very High Very High Very High
INFLAMMATION 10 80.08 Quite High
Rheumatoid Arthritis 19 70.40 Quite High
Disease 5 63.48 Quite High
Hyperplasia 3 28.56 Quite Low
Cancer 7 16.56 Low Low
Necrosis 3 5.00 Very Low Very Low Very Low
Stomach Cancer 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The extrinsic pathway known as death receptor stimulation (Fas, TNF-related apoptosis inducing ligand; TRAIL, TNF receptor-1) requires activation of caspase-8.
TRAIL Positive_regulation (requires) of Positive_regulation (activation) of caspase-8 associated with apoptosis and death
1) Confidence 0.01 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC373449 Disease Relevance 1.12 Pain Relevance 0.20

General Comments

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