INT17596

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 3.07
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CFHR1) extracellular region (CFHR1)
Anatomy Link Frequency
fibroblast 2
autonomic nervous system 1
HFL1 1
Mouse 1
forelimb 1
CFHR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 16 99.88 Very High Very High Very High
Morphine 4 98.76 Very High Very High Very High
Peripheral nervous system 1 97.96 Very High Very High Very High
epidural 1 94.96 High High
Dismenorea 6 94.36 High High
analgesia 1 94.24 High High
imagery 5 91.96 High High
narcan 7 89.28 High High
Opioid 2 78.48 Quite High
cytokine 8 78.40 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 25 99.88 Very High Very High Very High
Congenital Anomalies 30 98.92 Very High Very High Very High
Sprains And Strains 576 96.04 Very High Very High Very High
Dysmenorrhea 6 94.36 High High
Stress 8 89.76 High High
Cancer 20 88.32 High High
Infection 108 83.16 Quite High
Hypersensitivity 4 75.44 Quite High
Apoptosis 24 68.56 Quite High
INFLAMMATION 16 63.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was expected, because the hybrid CFH/CFHL1 gene described here would not be picked up by genomic sequencing using CFH-specific primers

CFH cDNA Sequencing

Gene_expression (picked) of CFHL1
1) Confidence 0.67 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0.14 Pain Relevance 0
If recombination occurred after the terminal exons of CFH and CFHL1 deletion of CFHL1 and CFHL3 would result.
Gene_expression (deletion) of CFHL1
2) Confidence 0.67 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0 Pain Relevance 0
Morphine administration significantly decreased FHR, but it increased FHR variation and forelimb movements (LM).
Gene_expression (variation) of FHR in forelimb associated with morphine
3) Confidence 0.64 Published 2001 Journal J. Appl. Physiol. Section Abstract Doc Link 11247963 Disease Relevance 0 Pain Relevance 0.70
In this preliminary study, conventional attributes of the FHR, alone or in combination, did not predict metabolic acidemia.
Gene_expression (attributes) of FHR
4) Confidence 0.55 Published 1991 Journal Obstet Gynecol Section Abstract Doc Link 1923162 Disease Relevance 0 Pain Relevance 0.14
Mouse polyclonal anti-CFHR1 antibody or mAb JHD 7.10 were used for detection of CFHR1 and CFHR2 and CFHR5 [41].
Gene_expression (detection) of CFHR1 in Mouse
5) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.08 Pain Relevance 0
Expression of recombinant CFHR1, CFHR2, and CFHR5
Gene_expression (Expression) of CFHR1
6) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.22 Pain Relevance 0
Recombinant FHL1 and CFHR1 were expressed in Spodoptera frugiperda Sf9 insect cells infected with recombinant baculovirus.
Gene_expression (expressed) of CFHR1
7) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.22 Pain Relevance 0
The human CFHR1 protein consists of five SCRs and exists in two glycosylated forms, the 37-kDa CFHR1?
Gene_expression (consists) of CFHR1 protein
8) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0 Pain Relevance 0
The potential of the single CFH/CFHR1-binding CRASP molecule for binding of additional members of the CFH protein family and the contribution of these CRASP proteins for complement resistance is still under debate.
Gene_expression (single) of CFHR1
9) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.27 Pain Relevance 0
The potential of the single CFH/CFHR1-binding CRASP molecule for binding of additional members of the CFH protein family and the contribution of these CRASP proteins for complement resistance is still under debate.
Gene_expression (contribution) of CFHR1
10) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.28 Pain Relevance 0
The mAB JHD 7.10 identified bands of 50-, 43-, 37-, 29-, and 24-kDa which represent CFHR1, CFHR2, and CFHR5, respectively (Fig. 4B).
Gene_expression (represent) of CFHR1 in bands
11) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.19 Pain Relevance 0
The human CFHR1 protein consists of five SCRs and exists in two glycosylated forms, the 37-kDa CFHR1?
Gene_expression (The) of CFHR1 protein
12) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0 Pain Relevance 0
Thus, CRASP-3 and CRASP-5 expressed on the surface of live borreliae bind the human serum proteins CFHR1 and CFHR2, CFHR5, and only miniscute amounts of CFH.


Gene_expression (expressed) of CFHR1
13) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.15 Pain Relevance 0
The human CFHR1 protein consists of five SCRs and exists in two glycosylated forms, the 37-kDa CFHR1?
Gene_expression (exists) of CFHR1 protein
14) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.05 Pain Relevance 0
In contrast, CFHR1 and CFHR2 as well as their glycosylated forms were readily detectable in the final glycine fraction suggesting that these serum proteins possess a stronger binding capacity to surface-exposed CRASP-3.
Gene_expression (detectable) of CFHR1
15) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.14 Pain Relevance 0
In contrast, CFHR1 was detectable in all fractions of transformants expressing CRASP-3 or CRASP-5 even in the highest concentration of NaCl as well as in the final glycine fraction.
Gene_expression (detectable) of CFHR1
16) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.22 Pain Relevance 0
Since the FHR pattern is primarily an expression of the activity of the control by the central and peripheral nervous system over cardiovascular haemodynamics, it is possibly too indirect a signal.
Gene_expression (expression) of FHR in peripheral nervous system associated with peripheral nervous system
17) Confidence 0.40 Published 1996 Journal Baillieres Clin Obstet Gynaecol Section Abstract Doc Link 8836480 Disease Relevance 0 Pain Relevance 0.05
Uterine contraction being a strong stimulus for the foetus and its autonomic nervous system, it is worth exploring the FHR variability response.
Gene_expression (exploring) of FHR in autonomic nervous system
18) Confidence 0.19 Published 2006 Journal Med Biol Eng Comput Section Abstract Doc Link 16937160 Disease Relevance 0.42 Pain Relevance 0.42
Exponentially growing TK6, Jurkat, HeLa, and HFL1
Gene_expression (growing) of HFL1 in HeLa
19) Confidence 0.11 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0 Pain Relevance 0.05
On the other hand, HeLa (epithelial origin), and HFL1 (fibroblast
Gene_expression (hand) of HFL1 in fibroblast
20) Confidence 0.11 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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