INT175960

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Context Info
Confidence 0.50
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 3.88
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RSF1) histone binding (RSF1) ATPase activity (RSF1)
nucleus (RSF1)
RSF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 119 99.74 Very High Very High Very High
methotrexate 20 98.32 Very High Very High Very High
rheumatoid arthritis 76 44.96 Quite Low
Neuropathic pain 3 41.80 Quite Low
depression 3 41.08 Quite Low
metalloproteinase 4 9.52 Low Low
cINOD 8 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
Rheumatism 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 218 100.00 Very High Very High Very High
INFLAMMATION 127 99.74 Very High Very High Very High
Cancer 268 98.84 Very High Very High Very High
Necrosis 12 92.28 High High
Carcinoma 3 86.24 High High
Breast Cancer 72 76.32 Quite High
Colon Cancer 3 49.16 Quite Low
Rheumatoid Arthritis 76 44.96 Quite Low
Neuropathic Pain 3 41.80 Quite Low
Depression 3 41.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SQLE (8q24.13) (p = 0.0268) and RSF1 (11q13.5) (p = 0.0067) were upregulated in ERBB2-amplified IBCs.
Positive_regulation (upregulated) of RSF1
1) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.56 Pain Relevance 0.21
Within 11q13.5-q14.1, RSF1, INTS4 and KCTD21 were upregulated in proportion to copy number gain/amplification in the ERBB2-amplified tumors.
Positive_regulation (upregulated) of RSF1 associated with cancer
2) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 1.06 Pain Relevance 0
This suggests that the upregulation of SQLE associated with gain or amplification could be a specific oncogenic mechanism in IBC whereas the upregulation of RSF1could be explained by others mechanisms such as hypomethylation of its promoter.


Positive_regulation (upregulation) of RSF1could associated with inflammation
3) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.25 Pain Relevance 0.12
Caspases are responsible for many of the biochemical and morphological changes that occur during apoptosis, so we investigated whether triptolide induced the activation of caspase-3 in RSF.
Spec (whether) Positive_regulation (activation) of RSF associated with apoptosis
4) Confidence 0.09 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC373449 Disease Relevance 0.35 Pain Relevance 0.03
activation in RSF
Positive_regulation (activation) of RSF
5) Confidence 0.08 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC373449 Disease Relevance 0.49 Pain Relevance 0
The present study showed that triptolide, which has been identified as a major active compound in TWHF extract, induced the apoptosis of RSF.
Positive_regulation (induced) of RSF associated with apoptosis
6) Confidence 0.06 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC373449 Disease Relevance 0.91 Pain Relevance 0.03
As shown in Figure 3, triptolide induced DNA fragmentation in cultured RSF, while bucillamine, D-penicillamine, and methotrexate did not affect cellular DNA.
Positive_regulation (induced) of RSF associated with methotrexate
7) Confidence 0.05 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC373449 Disease Relevance 0.26 Pain Relevance 0.09

General Comments

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