INT175961

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Context Info
Confidence 0.08
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.94
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
poly 1
T lymphocytes 1
polymerase (Homo sapiens)
polymerase - R722H (1)
Pain Link Frequency Relevance Heat
imagery 2 79.68 Quite High
Inflammation 27 69.92 Quite High
headache 4 61.52 Quite High
metalloproteinase 4 51.40 Quite High
COX-2 inhibitor 5 51.36 Quite High
Inflammatory mediators 3 50.00 Quite Low
cINOD 4 41.32 Quite Low
Angina 2 40.24 Quite Low
rheumatoid arthritis 19 31.40 Quite Low
methotrexate 5 13.68 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 63 99.92 Very High Very High Very High
Systemic Lupus Erythematosus 2 89.68 High High
Cancer 45 83.68 Quite High
Reprotox - General 1 1 82.36 Quite High
Solid Tumor 1 75.44 Quite High
Death 5 74.08 Quite High
INFLAMMATION 40 69.92 Quite High
Decompression Sickness 2 64.00 Quite High
Headache 4 61.52 Quite High
Convulsion 6 61.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The p.W748S mutation alone has been shown to cause a catalytic defect involving poor DNA synthesis and primer extension [33], which suggests that the compound p.R722H + p.W748S mutation in POLG1 may lead to dysfunction of the polymerase by alteration of the linker region according to a similar pattern.
Protein_catabolism (dysfunction) of polymerase
1) Confidence 0.08 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2873323 Disease Relevance 0.35 Pain Relevance 0.06
Molecular modeling of the wild-type or R722H mutation-carrying DNA polymerase-?
Protein_catabolism (carrying) of polymerase (R722H)
2) Confidence 0.08 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2873323 Disease Relevance 0.09 Pain Relevance 0.04
In addition, Sal-B induced caspase-dependent apoptosis by cleavage of a caspase substrate, poly (ADP) ribose polymerase (PARP).
Protein_catabolism (cleavage) of polymerase in poly associated with apoptosis
3) Confidence 0.03 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010684 Disease Relevance 0.61 Pain Relevance 0.09
Yang et al. [12] reported that over expression of Bcl-2, which inhibit mitochondrial intrinsic pathway, suppressed triptolide-induced degradation of poly ADP-ribose polymerase, a caspase substrate, and apoptosis of T lymphocytes.
Protein_catabolism (degradation) of polymerase in T lymphocytes associated with apoptosis
4) Confidence 0.02 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC373449 Disease Relevance 0.89 Pain Relevance 0
Nevertheless, as previously described, by exploiting the fact that the mismatched primers have slower reaction kinetics, the problems associated with ASE can be circumvented by including a protease (Proteinase K) that degrades the polymerase [14].
Protein_catabolism (degrades) of polymerase
5) Confidence 0.01 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1657021 Disease Relevance 0 Pain Relevance 0

General Comments

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