INT175966

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Context Info
Confidence 0.09
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.82
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Kctd1, CASP3) nucleoplasm (CASP3) mitochondrion (CASP3)
cytoplasm (CASP3) cytosol (CASP3) peptidase activity (CASP3)
Kctd1 (Rattus norvegicus)
CASP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 59.00 Quite High
rheumatoid arthritis 19 49.08 Quite Low
methotrexate 5 31.36 Quite Low
Inflammation 8 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Rheumatism 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 53 95.60 Very High Very High Very High
Death 4 91.76 High High
INFLAMMATION 10 58.76 Quite High
Rheumatoid Arthritis 19 49.08 Quite Low
Cancer 7 43.20 Quite Low
Disease 5 42.16 Quite Low
Stomach Cancer 1 22.24 Low Low
Hyperplasia 3 7.24 Low Low
Necrosis 3 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This triptolide-induced activation of caspase-3 was suppressed by Z-VAD-FMK, a pan-caspase inhibitor.
VAD Negative_regulation (suppressed) of Positive_regulation (activation) of caspase-3
1) Confidence 0.09 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC373449 Disease Relevance 0.82 Pain Relevance 0.06

General Comments

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