INT175968

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Context Info
Confidence 0.74
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.54
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
fat 1
cardiomyocytes 1
muscles 1
hearts 1
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 40 75.64 Quite High
tolerance 5 71.48 Quite High
Inflammation 10 35.04 Quite Low
Somatostatin 34 5.00 Very Low Very Low Very Low
Central nervous system 14 5.00 Very Low Very Low Very Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lifespan 68 100.00 Very High Very High Very High
Apoptosis 44 99.28 Very High Very High Very High
Aging 32 98.52 Very High Very High Very High
Injury 19 98.28 Very High Very High Very High
Disorders Of Creatine Metabolism 11 95.28 Very High Very High Very High
Myocardial Infarction 9 93.12 High High
Edema 12 89.80 High High
Hypertrophy 23 83.84 Quite High
Reperfusion Injury 17 81.44 Quite High
Cv Unclassified Under Development 33 75.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is also consistent with the cardiac performance and left ventricular contractility of IGF-1 treated hearts, that exhibited a greater ?
Phosphorylation (performance) of IGF-1 in hearts
1) Confidence 0.74 Published 2003 Journal Crit Care Section Body Doc Link PMC374373 Disease Relevance 0.95 Pain Relevance 0.07
Thereafter, however, mortality rate of bIGF1RKO+/?
Phosphorylation (rate) of bIGF1RKO
2) Confidence 0.58 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0.59 Pain Relevance 0
We therefore measured the lifespan of bIGF1RKO+/?
Phosphorylation (lifespan) of bIGF1RKO associated with lifespan
3) Confidence 0.51 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0.49 Pain Relevance 0.04
Unaltered IGF-I content in treated muscles supports a mechanism of increased Akt phosphorylation achieved through the inhibition of myostatin rather than increased IGF-I.
Phosphorylation (phosphorylation) of IGF-I in muscles
4) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.08 Pain Relevance 0
Shyu et al. have demonstrated that IGF-1, myostatin, and p38 phosphorylation increase subsequent to cyclic stretch of cardiomyocytes [27].
Phosphorylation (phosphorylation) of IGF-1 in cardiomyocytes
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2856679 Disease Relevance 0.32 Pain Relevance 0
The expression levels of the angiogenic factors, bFGF, IGF-1, PDGF-BB, VEGFR-2, EPOR and MMP-2, the cell survival factor PKB and phosphorylated PKB, and the pro-apoptotic factors caspase 3 and cytochrome c were determined in homogenates of the harvested fat grafts using western blot analysis.
Phosphorylation (phosphorylated) of IGF-1 in fat associated with apoptosis
6) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.10 Pain Relevance 0

General Comments

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