INT175986

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Context Info
Confidence 0.01
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 4.75
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) intracellular (Gtf3a) DNA binding (Gtf3a)
cell proliferation (Ros1) signal transduction (Ros1) RNA binding (Gtf3a)
Anatomy Link Frequency
neurons 1
microglial cells 1
oligodendrocytes 1
Ros1 (Mus musculus)
Gtf3a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 6 99.70 Very High Very High Very High
Inflammation 128 96.24 Very High Very High Very High
cytokine 26 95.72 Very High Very High Very High
ischemia 40 91.48 High High
Inflammatory mediators 12 78.60 Quite High
cINOD 81 64.80 Quite High
Dopamine 63 46.92 Quite Low
midbrain 36 36.40 Quite Low
antagonist 3 27.20 Quite Low
COX-2 inhibitor 9 22.68 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 158 99.54 Very High Very High Very High
Drug Induced Neurotoxicity 30 97.16 Very High Very High Very High
Parkinson's Disease 324 95.96 Very High Very High Very High
Apoptosis 13 94.60 High High
Death 9 93.60 High High
Reperfusion Injury 17 92.28 High High
Cv Unclassified Under Development 36 91.48 High High
Adhesions 3 90.16 High High
Injury 35 88.12 High High
Necrosis 8 84.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ROS activate transcription factors, such as nuclear factor-?
ROS Positive_regulation (activate) of factor
1) Confidence 0.01 Published 2003 Journal Crit Care Section Body Doc Link PMC374373 Disease Relevance 1.56 Pain Relevance 0.34
Inflammatory stimuli together with ROS and RNS activate nuclear factor-kB (NF-kB) in microglial cells, oligodendrocytes and neurons to promote the transcription of inflammatory cytokines, COX-2, iNOS, and apoptosis-promoting factor including p53/Bax [see [45,46]].
ROS Positive_regulation (activate) of factor in microglial cells associated with inflammation, apoptosis, cytokine and inflammatory stimuli
2) Confidence 0.00 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.06 Pain Relevance 0.46
Inflammatory stimuli together with ROS and RNS activate nuclear factor-kB (NF-kB) in microglial cells, oligodendrocytes and neurons to promote the transcription of inflammatory cytokines, COX-2, iNOS, and apoptosis-promoting factor including p53/Bax [see [45,46]].
ROS Positive_regulation (activate) of factor in neurons associated with inflammation, apoptosis, cytokine and inflammatory stimuli
3) Confidence 0.00 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.06 Pain Relevance 0.46
Inflammatory stimuli together with ROS and RNS activate nuclear factor-kB (NF-kB) in microglial cells, oligodendrocytes and neurons to promote the transcription of inflammatory cytokines, COX-2, iNOS, and apoptosis-promoting factor including p53/Bax [see [45,46]].
ROS Positive_regulation (activate) of factor in oligodendrocytes associated with inflammation, apoptosis, cytokine and inflammatory stimuli
4) Confidence 0.00 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 1.06 Pain Relevance 0.46

General Comments

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