INT1760

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Context Info
Confidence 0.57
First Reported 1975
Last Reported 2010
Negated 6
Speculated 5
Reported most in Abstract
Documents 524
Total Number 529
Disease Relevance 226.94
Pain Relevance 96.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER2) signal transducer activity (PTGER2)
Anatomy Link Frequency
PGE2 33
osteoblasts 33
cartilage 19
chondrocytes 19
fibroblasts 19
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 8724 100.00 Very High Very High Very High
Inflammation 6681 100.00 Very High Very High Very High
cytokine 2625 100.00 Very High Very High Very High
Inflammatory mediators 440 100.00 Very High Very High Very High
COX2 410 100.00 Very High Very High Very High
cINOD 1840 99.82 Very High Very High Very High
Inflammatory stimuli 222 99.82 Very High Very High Very High
dexamethasone 41 99.78 Very High Very High Very High
COX-2 inhibitor 1447 99.76 Very High Very High Very High
Kinase C 180 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoarthritis 9073 100.00 Very High Very High Very High
INFLAMMATION 8074 100.00 Very High Very High Very High
Cancer 2697 100.00 Very High Very High Very High
Herpes Simplex Virus 2618 100.00 Very High Very High Very High
Adhesions 642 100.00 Very High Very High Very High
Osteoporosis 321 100.00 Very High Very High Very High
Necrosis 291 100.00 Very High Very High Very High
Fever 258 100.00 Very High Very High Very High
Breast Cancer 668 99.98 Very High Very High Very High
Infection 1759 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although a novel promoter polymorphism (-765G > C) of COX-2 was not associated with AIA, the CC homozygote of this promoter polymorphism was associated with increased PGE2 production by creating an E2F transcription factor binding motif.27 Further studies are needed to clarify the role of COX-2 and PG imbalance in the pathogenic mechanisms of AIA in a Korean population.
Gene_expression (production) of PGE2 associated with asthma
1) Confidence 0.57 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 0.71 Pain Relevance 0.15
The PGE2-dependent stimulation of IGF-1 synthesis was due in part to the cAMP/protein kinase A pathway since both the direct inhibition of this pathway with H-89 and the inhibition of EP2 or EP4 receptors, linked to cAMP production, reduced IGF-1 synthesis.
Gene_expression (synthesis) of EP2 in PGE2
2) Confidence 0.53 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.25 Pain Relevance 0.70
There was a significant negative trend between the doses (10(-7)-10(-3) M) of each of indomethacin, piroxicam, and ibuprofen, and the amounts of PGF2 alpha, PGE2, PGD2, and 15-keto-PGE2 produced.
Gene_expression (produced) of PGE2
3) Confidence 0.53 Published 1983 Journal J. Dent. Res. Section Abstract Doc Link 6576002 Disease Relevance 0.15 Pain Relevance 0.15
With respect to PGE2 receptors, CRC cells and their neighboring cells have augmented expression of receptors EP2 and EP4, while initially the EP3 receptor expression often is lowered [4,8,12-15], Figure 1.
Gene_expression (expression) of EP2 in PGE2 associated with colorectal cancer
4) Confidence 0.51 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 0.77 Pain Relevance 0.41
COX, PGE2, and TBXA2R polymorphism
Gene_expression (COX) of PGE2
5) Confidence 0.50 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 0.61 Pain Relevance 0.09
We studied all aspects of the actual measurement of PGE2 including the extraction efficiency of the PGE2 from the mucosa, the precision of the assay and calculation of the PGE2 content in terms of milligrams of protein in the sample, the inhibition of PGE2 by indomethacin over time, the reproducibility of the measurement within one homogenate, the rate of PGE2 production over time, the effect of adding indomethacin versus snap freezing on PGE2 production, the stability of PGE2 in tissues over time stored in liquid nitrogen, and the variability of the measurement of PGE2 in separate biopsies from one individual.
Gene_expression (production) of PGE2 in PGE2
6) Confidence 0.48 Published 1995 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 7606198 Disease Relevance 0.54 Pain Relevance 0.20
We studied all aspects of the actual measurement of PGE2 including the extraction efficiency of the PGE2 from the mucosa, the precision of the assay and calculation of the PGE2 content in terms of milligrams of protein in the sample, the inhibition of PGE2 by indomethacin over time, the reproducibility of the measurement within one homogenate, the rate of PGE2 production over time, the effect of adding indomethacin versus snap freezing on PGE2 production, the stability of PGE2 in tissues over time stored in liquid nitrogen, and the variability of the measurement of PGE2 in separate biopsies from one individual.
Gene_expression (production) of PGE2 in PGE2
7) Confidence 0.48 Published 1995 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 7606198 Disease Relevance 0.56 Pain Relevance 0.21
These apparent COX-isotype dependencies of TXA2 and PGE2 synthesis can be explained by differences in the affinities of TXA synthase and PGE synthase for the common substrate, PGH2.
Gene_expression (synthesis) of PGE2 in PGE2
8) Confidence 0.47 Published 2001 Journal Inflamm. Res. Section Abstract Doc Link 11409487 Disease Relevance 0.33 Pain Relevance 0.25
Therefore, it is potentially significant that production of TXA2 and PGE2 by stimulated monocytes have very different time courses.
Gene_expression (production) of PGE2 in monocytes
9) Confidence 0.47 Published 2001 Journal Inflamm. Res. Section Abstract Doc Link 11409487 Disease Relevance 0.36 Pain Relevance 0.23
There was a significant negative trend between the doses (10(-7)-10(-3) M) of each of indomethacin, piroxicam, and ibuprofen, and the amounts of PGF2 alpha, PGE2, PGD2, and 15-keto-PGE2 produced.
Gene_expression (produced) of PGE2
10) Confidence 0.46 Published 1983 Journal J. Dent. Res. Section Abstract Doc Link 6576002 Disease Relevance 0.15 Pain Relevance 0.15
Furthermore, an in vitro study performed on inflammatory cells demonstrated that eosinophils express high levels of EP2 and EP4 mRNA in comparison with EP1 and EP3, which were almost not present in these cells and that deficiency of PGE2 production may up-regulate the expression of EP2 and EP4 molecules [30].
Gene_expression (expression) of EP2 in eosinophils associated with inflammation
11) Confidence 0.46 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.31 Pain Relevance 0.25
Furthermore, an in vitro study performed on inflammatory cells demonstrated that eosinophils express high levels of EP2 and EP4 mRNA in comparison with EP1 and EP3, which were almost not present in these cells and that deficiency of PGE2 production may up-regulate the expression of EP2 and EP4 molecules [30].
Gene_expression (express) of EP2 in eosinophils associated with inflammation
12) Confidence 0.46 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.36 Pain Relevance 0.29
These mutations may both affect PGE2 production per se via a regulation of COX enzymes in pro-inflammatory cells including epithelial cells as well as the PGE2-dependent signaling pathways in target cells, Figure 1.
Gene_expression (production) of PGE2 in PGE2 associated with inflammation
13) Confidence 0.45 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 1.17 Pain Relevance 0.27
Human peripheral blood mononuclear cells produce a factor (MCF) that regularly stimulates the production of PGE2 and collagenase from resting ASC often by over 100-fold.
Gene_expression (production) of PGE2 in ASC
14) Confidence 0.43 Published 1979 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 231404 Disease Relevance 0.46 Pain Relevance 0.27
Conversely, only the high OA group showed a significant inhibition of IGF-1 production when PGE2 synthesis was reduced with Naproxen, a non-steroidal antiinflammatory drug (NSAID) that inhibits cyclooxygenases (COX).
Gene_expression (synthesis) of PGE2 in PGE2 associated with inflammation, cinod and osteoarthritis
15) Confidence 0.42 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.53 Pain Relevance 0.68
We previously reported that OA osteoblasts (Ob) show abnormal phenotypic characteristics possibly responsible for bone sclerosis and that two subgroups of OA patients can be identified by low or high endogenous production of prostaglandin E2 (PGE2) by OA Ob.
Gene_expression (production) of PGE2 in osteoblasts associated with sclerosis and osteoarthritis
16) Confidence 0.42 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.34 Pain Relevance 0.49
Analysing closely these results one may suggest that although synthesis of PGE2 may be related to eosinophil activation, regulation of its receptors at least at mRNA levels depends of mechanisms involving other cellular sources as showed recently by Ying and col. [15].
Gene_expression (synthesis) of PGE2 in eosinophil
17) Confidence 0.40 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.11 Pain Relevance 0.14
Furthermore, an in vitro study performed on inflammatory cells demonstrated that eosinophils express high levels of EP2 and EP4 mRNA in comparison with EP1 and EP3, which were almost not present in these cells and that deficiency of PGE2 production may up-regulate the expression of EP2 and EP4 molecules [30].
Gene_expression (production) of PGE2 in eosinophils associated with inflammation
18) Confidence 0.40 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.31 Pain Relevance 0.25
However, in the CRS and EP1 and EP3 receptors were down-expressed compared to EP2 and EP4 and this difference was more accentuated in the CRS-NP subjects.
Gene_expression (expressed) of EP2
19) Confidence 0.40 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.22 Pain Relevance 0.07
Of the four employed EP receptor agonists, PGE2 induced the largest increase in SCC (i.e. electrogenic secretion), which is not surprising as PGE2 stimulates all four EP receptor subtypes.
Neg (not) Gene_expression (stimulates) of PGE2 associated with agonist
20) Confidence 0.39 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 0 Pain Relevance 0.05

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