INT176013

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.18
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MTHFR) small molecule metabolic process (MTHFR) oxidoreductase activity (MTHFR)
cellular amino acid metabolic process (MTHFR)
MTHFR (Homo sapiens)
MTHFR - C677T (1)
Pain Link Frequency Relevance Heat
Migraine 77 100.00 Very High Very High Very High
depression 45 100.00 Very High Very High Very High
Serotonin 1 64.32 Quite High
Dopamine 3 63.12 Quite High
monoamine 2 62.44 Quite High
antidepressant 19 5.00 Very Low Very Low Very Low
headache 8 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
fluoxetine 3 5.00 Very Low Very Low Very Low
sSRI 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 79 100.00 Very High Very High Very High
Depression 70 100.00 Very High Very High Very High
Disease 13 74.20 Quite High
Migraine With Aura 44 71.08 Quite High
Migraine Without Aura 18 70.60 Quite High
Reprotox - General 1 1 44.72 Quite Low
Stroke 11 5.00 Very Low Very Low Very Low
Cognitive Disorder 7 5.00 Very Low Very Low Very Low
Cardiovascular Disease 5 5.00 Very Low Very Low Very Low
Mental Disorders 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then conducted a meta-analysis of studies investigating the association between depression and MTHFR genotype, including our own data from HIMS.
Spec (investigating) Negative_regulation (depression) of MTHFR Binding (association) of associated with depression
1) Confidence 0.42 Published 2010 Journal Trials Section Body Doc Link PMC2822769 Disease Relevance 0.56 Pain Relevance 0.37
That is, inheritance phase was indiscernible in many families and therefore the power to detect the expected association of the MTHFR C677T variant and migraine, as detected in the unrelated case-control analysis, was severely diminished.
Negative_regulation (diminished) of MTHFR C677T (C677T) Binding (association) of associated with migraine
2) Confidence 0.42 Published 2004 Journal BMC Med Section Body Doc Link PMC375543 Disease Relevance 0.62 Pain Relevance 0.26

General Comments

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