INT176033

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Context Info
Confidence 0.33
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.56
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMGCR) oxidoreductase activity (HMGCR) endoplasmic reticulum (HMGCR)
peroxisome (HMGCR)
Anatomy Link Frequency
blood 1
adipocytes 1
HMGCR (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 1 51.60 Quite High
agonist 42 50.00 Quite Low
Inflammatory mediators 7 39.24 Quite Low
Bile 31 31.56 Quite Low
Inflammation 41 23.16 Low Low
antagonist 40 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
local anesthetic 11 5.00 Very Low Very Low Very Low
Bioavailability 9 5.00 Very Low Very Low Very Low
Angina 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 208 98.96 Very High Very High Very High
Disorder Of Lipid Metabolism 113 98.64 Very High Very High Very High
Stomach Cancer 3 98.28 Very High Very High Very High
Leukemia 3 97.32 Very High Very High Very High
Malignant Neoplastic Disease 10 95.44 Very High Very High Very High
Stress 42 94.76 High High
Lung Cancer 10 86.56 High High
Hematologic Neoplasms 1 79.68 Quite High
Breast Cancer 29 78.64 Quite High
Hypoxia 24 77.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased blood cholesterol, APOE 4 allele, increased blood hcy, increased ACT and VitB12, and the mutate allele of HMGCR gene.
Positive_regulation (increased) of HMGCR in blood
1) Confidence 0.33 Published 2010 Journal Immun Ageing Section Body Doc Link PMC3024878 Disease Relevance 0.38 Pain Relevance 0
In order to determine whether the apoA-I induced efflux derives from a regulatory pool of cholesterol and is therefore associated with an increase in HMG-CoA reductase activity, we treated the adipocytes with a statin, which is a known inhibitor of this enzyme.
Positive_regulation (increase) of HMG-CoA reductase in adipocytes associated with obesity
2) Confidence 0.25 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.31 Pain Relevance 0
Inhibition of HMG-CoA reductase by simvastatin has no effect on the apoA-I induced release of cholesterol (figure 4) suggesting that the increase in cholesterol in the cell medium derives from a cholesterol storage pool not related to a feed-back activation of HMG-CoA reductase.
Positive_regulation (activation) of HMG-CoA reductase
3) Confidence 0.18 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.19 Pain Relevance 0
Thirdly, apoA-I does not induce an increase in extracellular cholesterol by the activation of HMG-CoA reductase since the use of specific inhibiting molecules does not block the effect of the apoA-I (figure 4).
Positive_regulation (activation) of HMG-CoA reductase
4) Confidence 0.18 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.13 Pain Relevance 0
Other studies have shown a down-regulation of SREBP-2, a gene encoding the sterol regulatory element-binding protein-2 that mediates cholesterol synthesis, as well as the two SREBP-2 target genes, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR) and low density lipoprotein receptor (LDLR), in HepG2 cells exposed to 30??
Positive_regulation (encoding) of HMGCR
5) Confidence 0.17 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.56 Pain Relevance 0.03
Finally, transcripts of several enzymes of the cholesterol biosynthesis pathway (CYP51A1, FDFT1, HMGCR, SC4MOL, SC5DL) were marginally increased.


Positive_regulation (increased) of HMGCR
6) Confidence 0.15 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.47 Pain Relevance 0
Deregulated or elevated HMG-CoA reductase activity has been shown in colorectal and gastric carcinomas, and leukemia [319-321].
Positive_regulation (elevated) of HMG-CoA reductase associated with leukemia and stomach cancer
7) Confidence 0.10 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.44 Pain Relevance 0
Due to removal of the drug, other statins have even been found to increase ex-vivo HMG-CoA reductase activity [56].
Positive_regulation (increase) of HMG-CoA reductase
8) Confidence 0.04 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC385249 Disease Relevance 0.08 Pain Relevance 0

General Comments

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