INT176039

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.17
First Reported 2004
Last Reported 2009
Negated 2
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.32
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMGCR) oxidoreductase activity (HMGCR) endoplasmic reticulum (HMGCR)
peroxisome (HMGCR)
Anatomy Link Frequency
SCP 1
ovary 1
HMGCR (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 10 100.00 Very High Very High Very High
abdominal pain 4 86.48 High High
backache 1 84.96 Quite High
Bile 31 77.36 Quite High
antagonist 37 5.00 Very Low Very Low Very Low
Inflammation 37 5.00 Very Low Very Low Very Low
Angina 17 5.00 Very Low Very Low Very Low
local anesthetic 11 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dysgerminoma 29 99.68 Very High Very High Very High
Stomach Cancer 3 98.28 Very High Very High Very High
Leukemia 3 97.32 Very High Very High Very High
Malignant Neoplastic Disease 11 96.04 Very High Very High Very High
Renal Disease 5 95.20 Very High Very High Very High
Cancer 165 93.60 High High
Fatigue 2 88.96 High High
Arthralgia 1 88.24 High High
Cardiovascular Disease 33 87.76 High High
Disorder Of Lipid Metabolism 78 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ezetimibe had no significant effects on the bioavailability of warfarin, fenofibrate, HMG CoA reductase inhibitors, or digoxin [16,18-20].
Regulation (effects) of HMG CoA reductase associated with bioavailability
1) Confidence 0.17 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC524501 Disease Relevance 0.86 Pain Relevance 0.25
In contrast, we observed that SCD1 was strongly underexpressed while HMGCR was not affected in the dysgerminoma compared to normal ovary.
Neg (not) Regulation (affected) of HMGCR in ovary associated with dysgerminoma
2) Confidence 0.16 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2727492 Disease Relevance 0.67 Pain Relevance 0
and atorvastatin in the presence or absence of mevalonate, FPP, and GGPP to determine whether atorvastatin inhibition of ENA-78 production was dependent on HMG-CoA reductase inhibition and subsequent downstream pathways.
Spec (whether) Regulation (dependent) of HMG-CoA reductase
3) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518836 Disease Relevance 0 Pain Relevance 0
Deregulated or elevated HMG-CoA reductase activity has been shown in colorectal and gastric carcinomas, and leukemia [319-321].
Regulation (Deregulated) of HMG-CoA reductase associated with leukemia and stomach cancer
4) Confidence 0.14 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.44 Pain Relevance 0
Unlike statins which inhibit cholesterol biosynthesis by directly affecting the rate-limiting enzyme HMG-CoA reductase, SCP seems to have a different, more complex mechanism of action [5].
Regulation (affecting) of HMG-CoA reductase in SCP
5) Confidence 0.08 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2390548 Disease Relevance 0.06 Pain Relevance 0
Lovastatin could have different effects on HMG-CoA reductase and other enzymes than simvastatin, and was not however examined in the above study.
Regulation (effects) of HMG-CoA reductase
6) Confidence 0.04 Published 2004 Journal Lipids Health Dis Section Body Doc Link PMC385249 Disease Relevance 0.06 Pain Relevance 0.04
Similarly no significant changes were observed in any of the three regulatory hepatic enzymes involved, namely CYP7, ACAT and HMG-CoA Reductase (Table 5).


Neg (no) Regulation (changes) of HMG-CoA Reductase
7) Confidence 0.01 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1262701 Disease Relevance 0.23 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox