INT176063

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 4.28
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (SQLE) oxidoreductase activity (SQLE) endoplasmic reticulum (SQLE)
SQLE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 89 96.72 Very High Very High Very High
Angina 12 94.32 High High
depression 45 92.16 High High
Neuropathic pain 3 43.08 Quite Low
cytokine 2 34.52 Quite Low
imagery 2 29.12 Quite Low
IPN 6 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
beta blocker 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 72 98.12 Very High Very High Very High
INFLAMMATION 89 96.72 Very High Very High Very High
Arrhythmias 2 Under Development 2 96.68 Very High Very High Very High
Cancer 240 95.88 Very High Very High Very High
Disorder Of Lipid Metabolism 10 94.48 High High
Angina 6 94.32 High High
Bundle-branch Block 2 94.08 High High
Pressure And Volume Under Development 4 92.68 High High
Disease 57 92.64 High High
Depression 45 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that the upregulation of SQLE associated with gain or amplification could be a specific oncogenic mechanism in IBC whereas the upregulation of RSF1could be explained by others mechanisms such as hypomethylation of its promoter.


Positive_regulation (upregulation) of SQLE associated with inflammation
1) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.25 Pain Relevance 0.13
SQLE (8q24.13) (p = 0.0268) and RSF1 (11q13.5) (p = 0.0067) were upregulated in ERBB2-amplified IBCs.
Positive_regulation (upregulated) of SQLE
2) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.62 Pain Relevance 0.22
Only C8orf53, MAL2, LOC286052, SQLE and KIAA0196 were upregulated in proportion to copy number gain or amplification of the 8q23.3-q24.21 region in the ERBB2-amplified tumors.
Positive_regulation (upregulated) of SQLE associated with cancer
3) Confidence 0.24 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.80 Pain Relevance 0
2 mm 0.08 s after the J point in the precordial leads) during a SE with no changes in wall motion score, (4) coronary angiogram performed within 20 days after SE, (5) no nitrate therapy at the time of SE.
Positive_regulation (time) of SE
4) Confidence 0.20 Published 2004 Journal BMC Cardiovasc Disord Section Body Doc Link PMC387825 Disease Relevance 0.95 Pain Relevance 0.33
All of the patients underwent dipyridamole SE.
Positive_regulation (underwent) of SE
5) Confidence 0.18 Published 2004 Journal BMC Cardiovasc Disord Section Body Doc Link PMC387825 Disease Relevance 1.44 Pain Relevance 0.33
The impact of imperfect Se and Sp on estimates of heritability can be deduced assuming that the classification errors are independent for u and w, and unrelated to Du or Dw.
Positive_regulation (deduced) of Se
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812510 Disease Relevance 0.21 Pain Relevance 0

General Comments

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