INT176063

Context Info Confidence 0.36 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 6 Disease Relevance 4.28 Pain Relevance 1.00

small molecule metabolic process (SQLE) oxidoreductase activity (SQLE) endoplasmic reticulum (SQLE)

SQLE (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 89 96.72 Angina 12 94.32 depression 45 92.16 Neuropathic pain 3 43.08 cytokine 2 34.52 imagery 2 29.12 IPN 6 5.00 alcohol 3 5.00 beta blocker 2 5.00 antagonist 2 5.00

Disease Link Frequency Relevance Heat Breast Cancer 72 98.12 INFLAMMATION 89 96.72 Arrhythmias 2 Under Development 2 96.68 Cancer 240 95.88 Disorder Of Lipid Metabolism 10 94.48 Angina 6 94.32 Bundle-branch Block 2 94.08 Pressure And Volume Under Development 4 92.68 Disease 57 92.64 Depression 45 92.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This suggests that the upregulation of SQLE associated with gain or amplification could be a specific oncogenic mechanism in IBC whereas the upregulation of RSF1could be explained by others mechanisms such as hypomethylation of its promoter.

Positive_regulation (upregulation) of SQLE associated with inflammation

1) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.25 Pain Relevance 0.13

SQLE (8q24.13) (p = 0.0268) and RSF1 (11q13.5) (p = 0.0067) were upregulated in ERBB2-amplified IBCs.

Positive_regulation (upregulated) of SQLE

2) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.62 Pain Relevance 0.22

Only C8orf53, MAL2, LOC286052, SQLE and KIAA0196 were upregulated in proportion to copy number gain or amplification of the 8q23.3-q24.21 region in the ERBB2-amplified tumors.

Positive_regulation (upregulated) of SQLE associated with cancer

3) Confidence 0.24 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.80 Pain Relevance 0

2 mm 0.08 s after the J point in the precordial leads) during a SE with no changes in wall motion score, (4) coronary angiogram performed within 20 days after SE, (5) no nitrate therapy at the time of SE.

Positive_regulation (time) of SE

4) Confidence 0.20 Published 2004 Journal BMC Cardiovasc Disord Section Body Doc Link PMC387825 Disease Relevance 0.95 Pain Relevance 0.33

All of the patients underwent dipyridamole SE.

Positive_regulation (underwent) of SE

5) Confidence 0.18 Published 2004 Journal BMC Cardiovasc Disord Section Body Doc Link PMC387825 Disease Relevance 1.44 Pain Relevance 0.33

The impact of imperfect Se and Sp on estimates of heritability can be deduced assuming that the classification errors are independent for u and w, and unrelated to Du or Dw.

Positive_regulation (deduced) of Se

6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812510 Disease Relevance 0.21 Pain Relevance 0

General Comments

This test has worked.