INT176079

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.15
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Tek) kinase activity (Tek)
Anatomy Link Frequency
pericytes 1
thymus 1
Tek (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 17 99.38 Very High Very High Very High
Potency 4 64.20 Quite High
anesthesia 7 59.80 Quite High
Inflammation 26 58.40 Quite High
cytokine 11 57.36 Quite High
chemokine 4 41.88 Quite Low
metalloproteinase 10 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 86 99.72 Very High Very High Very High
Hyperglycemia 27 98.16 Very High Very High Very High
Cancer 186 93.12 High High
Diabetic Retinopathy 22 93.12 High High
Leukemia 5 89.28 High High
Colon Cancer 6 89.12 High High
Carcinoma 1 82.08 Quite High
Burns 30 81.24 Quite High
Melanoma 17 80.40 Quite High
Metastasis 14 66.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it is possible that undetectable levels of expression in the thymus or elsewhere in VWF-lacZ and TIE2-lacZ mice cause an incomplete central tolerance that is responsible for their acceptance of TIE2-lacZ skin.
Positive_regulation (acceptance) of TIE2 in thymus associated with tolerance
1) Confidence 0.41 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 0.22 Pain Relevance 0.18
The cells were then trypsinized for 1 minute, centrifuged, washed with PBS, fixed in 4% paraformaldehyde for 0.5 hour at room temperature, washed and blocked in 2%FCS for 0.5 hour at room temperature with agitation. 1.5×105cells were then incubated with each of the following conjugated monoclonal antibodies: Tie-2, Flk-1, CD34, c-Kit, Thy-1, Sca-1 (PharMingen, San Diego, CA) for 90 mins at room temperature.
Positive_regulation (incubated) of Tie-2
2) Confidence 0.37 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0.24 Pain Relevance 0.06
The DNA fragments of murine endostatin (mEndo), murine-soluble vascular endothelial growth factor receptor 2 (msFlk-1) and murine-soluble Tie2 (msTie2) were generated by polymerase chain reaction (PCR).
Positive_regulation (generated) of Tie2
3) Confidence 0.32 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2830023 Disease Relevance 0.34 Pain Relevance 0.03
The DNA fragments of murine endostatin (mEndo), murine-soluble vascular endothelial growth factor receptor 2 (msFlk-1) and murine-soluble Tie2 (msTie2) were generated by polymerase chain reaction (PCR).
Positive_regulation (generated) of msTie2
4) Confidence 0.28 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2830023 Disease Relevance 0.33 Pain Relevance 0.03
Another approach targeting this complex pathway has been to block Tie2 activation by the presence of a recombinant, soluble Tie2 receptor.
Positive_regulation (activation) of Tie2
5) Confidence 0.16 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 1.05 Pain Relevance 0.06
Like E-RoSH cells, plating of E-RoSHL1 cells on matrigel dramatically increased expression of endothelial markers such as Tie-2, Flk-1, c-kit, Sca1 and thy1 within 60 hours (fig. 5d) and they formed a network of vascular structures that covered the entire culture dish after one week (fig. 5e).


Positive_regulation (ly increa) of Tie-2
6) Confidence 0.15 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0 Pain Relevance 0
Because methylglyoxal is the predominant intracellular AGE in the diabetic retina, this study links biochemical changes of diabetes to increased activation of the Ang-2/Tie-2 system and therefore to our observation that hyperglycemia enhances detachment and migration of pericytes from microvasculature, resulting in the typical pericyte loss of diabetic retinopathy.
Positive_regulation (activation) of Tie-2 in pericytes associated with hyperglycemia, diabetes mellitus and diabetic retinopathy
7) Confidence 0.10 Published 2008 Journal Diabetes Section Body Doc Link PMC2518502 Disease Relevance 0.97 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox