INT176080

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 2.34
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Fgfr2) Golgi apparatus (Fgfr2) plasma membrane (Fgfr2)
nucleus (Fgfr2) kinase activity (Fgfr2) cell-cell signaling (Fgfr2)
Anatomy Link Frequency
keratinocytes 2
mesenchyme 1
exocrine pancreas 1
epidermis 1
T cells 1
Fgfr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 112 82.40 Quite High
cytokine 34 55.28 Quite High
tolerance 17 37.52 Quite Low
psoriasis 4 23.84 Low Low
Inflammatory response 20 5.00 Very Low Very Low Very Low
member 8 8 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 158 98.36 Very High Very High Very High
Congenital Anomalies 44 94.24 High High
Acanthosis 32 91.68 High High
Aging 16 86.64 High High
Psoriasis 28 85.92 High High
INFLAMMATION 124 82.40 Quite High
Alopecia 12 78.44 Quite High
Sprains And Strains 21 76.36 Quite High
Apoptosis 24 71.52 Quite High
Immunization 21 70.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fgfr2 is expressed in the pancreatic epithelium and is activated by Fgf10 from the mesenchyme, a signal that is important for proliferating pancreatic progenitor cells [19,32,33].
Gene_expression (expressed) of Fgfr2 in mesenchyme
1) Confidence 0.68 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0.07 Pain Relevance 0
This was surprising because FGFs are potent mitogens for keratinocytes, and because epidermal hypotrophy was observed in the skin of newborn mice lacking FGFR2IIIb in all cells (Petiot et al., 2003) as well as in the skin of adult mice expressing a dominant-negative FGFR2IIIb mutant in keratinocytes (Werner et al., 1994).
Neg (lacking) Gene_expression (lacking) of FGFR2IIIb in keratinocytes
2) Confidence 0.64 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.49 Pain Relevance 0.08
Genotyping PCR for the Fgfr2 floxed allele was performed using primers FGFR2F5 (5?
Gene_expression (floxed) of Fgfr2
3) Confidence 0.64 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.13 Pain Relevance 0
This was surprising because FGFs are potent mitogens for keratinocytes, and because epidermal hypotrophy was observed in the skin of newborn mice lacking FGFR2IIIb in all cells (Petiot et al., 2003) as well as in the skin of adult mice expressing a dominant-negative FGFR2IIIb mutant in keratinocytes (Werner et al., 1994).
Gene_expression (expressing) of FGFR2IIIb in keratinocytes
4) Confidence 0.58 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.60 Pain Relevance 0.16
Real-time RT-PCR using RNA from isolated epidermis of control and mutant mice demonstrated a strong reduction of Fgfr1 and Fgfr2 expression (Fig. 1 B) in newborn single and double knockout mice, which further declined until postnatal day 18 (P18; Fig. 1 B and not depicted).
Gene_expression (expression) of Fgfr2 in epidermis associated with targeted disruption
5) Confidence 0.58 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.26 Pain Relevance 0
GeneChip studies also revealed a 1.7 fold decrease in the expression of transcripts encoding Fgfr2 at E14.5, consistent with the role of this receptor in exocrine pancreas development [19].
Gene_expression (expression) of Fgfr2 in exocrine pancreas
6) Confidence 0.51 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1783845 Disease Relevance 0 Pain Relevance 0
Activated T cells were detected by their expression of CD25 (IL-2 growth factor receptor) and effector functions were assessed by measuring IFN-?
Gene_expression (expression) of IL-2 growth factor receptor in T cells
7) Confidence 0.15 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 0.78 Pain Relevance 0

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