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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.36
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Tek) kinase activity (Tek)
Anatomy Link Frequency
endothelial cell 1
retina 1
bone marrow 1
Tek (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 1 85.16 High High
ischemia 48 81.96 Quite High
imagery 103 79.52 Quite High
tolerance 17 46.28 Quite Low
Inflammation 16 35.36 Quite Low
cytokine 13 25.92 Quite Low
withdrawal 5 24.96 Low Low
anesthesia 7 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Burns 15 98.76 Very High Very High Very High
Diabetes Mellitus 89 97.32 Very High Very High Very High
Wound Healing 5 91.28 High High
Targeted Disruption 85 90.56 High High
Diabetic Retinopathy 22 90.08 High High
Cancer 82 88.72 High High
Vibrio Infection 23 85.08 High High
Peripheral Arterial Disease 6 84.32 Quite High
Cv Unclassified Under Development 47 81.96 Quite High
Leukemia 1 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In TIE2-lacZ mice, a portion of the promoter and first intron of the gene encoding TIE2, the receptor for the vascular differentiation factor angiopoietin-1, drives the expression of ?
Regulation (intron) of TIE2
1) Confidence 0.37 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 0.51 Pain Relevance 0
In order to do so, this mouse expresses Biotin Ligase (BirA) and a cluster of BirA substrate sequences (Biotags) fused to a transmembrane domain under control of the endothelial cell specific Tie2 promoter.
Regulation (control) of Tie2 in endothelial cell
2) Confidence 0.32 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 0.59 Pain Relevance 0.11
In this study, we investigated the anti-angiogenic activity of strategies targeting VEGF, Tie2, and Endo to inhibit alkaline burn-induced corneal NV in mice.

Regulation (targeting) of Tie2 associated with burns
3) Confidence 0.19 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2830023 Disease Relevance 0.39 Pain Relevance 0.04
Tie2 and Hes3 immunoreactivity are lost following induction of differentiation.
Regulation (immunoreactivity) of Tie2
4) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.23 Pain Relevance 0
Our previous data revealed the importance of the Ang-2/Tie-2 system in the regulation of vascular morphological changes in the diabetic retina.
Regulation (importance) of Tie-2 in retina associated with diabetes mellitus
5) Confidence 0.11 Published 2008 Journal Diabetes Section Body Doc Link PMC2518502 Disease Relevance 1.02 Pain Relevance 0.04
One of the first observations that bone marrow contains high numbers of endothelial progenitor cells was by Ashara et al using infusion of bone marrow cells in which the beta-galactosidase marker was expressed under control of endothelial cell-specific promoters such as Flk-1 and Tie-2.
Regulation (control) of Tie-2 in bone marrow
6) Confidence 0.04 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0.61 Pain Relevance 0.22

General Comments

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