INT176088

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 39
Total Number 40
Disease Relevance 14.25
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Tek) kinase activity (Tek)
Anatomy Link Frequency
skin 3
adult brain 2
TEK 2
tongues 1
bone marrow 1
Tek (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 9 99.68 Very High Very High Very High
imagery 231 98.04 Very High Very High Very High
anesthesia 40 95.24 Very High Very High Very High
Arthritis 6 91.52 High High
tolerance 119 89.88 High High
rheumatoid arthritis 30 87.32 High High
Inflammation 203 85.36 High High
ischemia 48 82.60 Quite High
cytokine 65 69.72 Quite High
ketamine 26 57.00 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 533 100.00 Very High Very High Very High
Vibrio Infection 69 99.58 Very High Very High Very High
Infection 147 99.28 Very High Very High Very High
Cancer 386 98.78 Very High Very High Very High
Pox Virus Infection 42 98.64 Very High Very High Very High
Injury 132 98.28 Very High Very High Very High
Sprains And Strains 68 94.56 High High
Diabetes Mellitus 89 93.76 High High
Autoimmune Disease 22 92.84 High High
Arthritis 5 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fixed tongues were then embedded in Tissue-Tek OCT compound (Sakura, Tokyo, Japan) and 12–20 ?
Gene_expression (compound) of Tek in tongues
1) Confidence 0.65 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.08 Pain Relevance 0
The sampled tissue was immediately embedded in Tissue-Tek® OCT compound (Sakura, Zoeterwoude, the Netherlands) and snap frozen in liquid nitrogen.


Gene_expression (compound) of Tek
2) Confidence 0.65 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064871 Disease Relevance 0.74 Pain Relevance 0.34
Despite the relatively high transcript levels of PDGFRa, Tie2, c-kit, CD59, CD63, CD44 and CD24 in RoSH and E-RoSH cells, they were not immunoreactive against PDGFRa, Tie2, c-kit, CD59, CD63, CD44 and CD24 (data not shown).
Gene_expression (levels) of Tie2
3) Confidence 0.57 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0.25 Pain Relevance 0
-gal mRNA in VWF-lacZ hearts and TIE2-lacZ thymus tissues (not shown).
Gene_expression (hearts) of TIE2 in hearts
4) Confidence 0.56 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 0.31 Pain Relevance 0.16
Wild type FVB, VWF-lacZ, and TIE2-lacZ mice all responded to ?
Gene_expression (responded) of TIE2
5) Confidence 0.56 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 1.35 Pain Relevance 0
-gal in immunized and unimmunized TIE2-lacZ and VWF-lacZ mice but not in control FVB mice (Figure 4A).
Gene_expression (unimmunized) of TIE2
6) Confidence 0.56 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 0.40 Pain Relevance 0
Wild type FVB, VWF-lacZ, and TIE2-lacZ mice all responded to ?
Gene_expression (Wild type FVB) of TIE2
7) Confidence 0.56 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 1.40 Pain Relevance 0
Skin grafts between transgenic TIE2-lacZ and wild type FVB mice appeared to survive equivalently on both hosts (5 separate experiments, totaling over 20 host mice of each strain).
Gene_expression (grafts) of TIE2 in Skin associated with targeted disruption and sprains and strains
8) Confidence 0.56 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 0.46 Pain Relevance 0.04
All TIE2-lacZ skin grafts transplanted onto VWF-lacZ mice contained many ?
Gene_expression (grafts) of TIE2 in skin
9) Confidence 0.56 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 0.11 Pain Relevance 0
-gal+ EC in TIE2-lacZ skin grafts (Figure 6B) strongly suggests that specific lymphocytes directly recognize and are rendered unresponsive by resting, endogenous, ?
Gene_expression (gal+) of TIE2 in skin
10) Confidence 0.56 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 0.15 Pain Relevance 0.09
Despite the relatively high transcript levels of PDGFRa, Tie2, c-kit, CD59, CD63, CD44 and CD24 in RoSH and E-RoSH cells, they were not immunoreactive against PDGFRa, Tie2, c-kit, CD59, CD63, CD44 and CD24 (data not shown).
Neg (not) Gene_expression (immunoreactive) of Tie2
11) Confidence 0.50 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0.24 Pain Relevance 0
Expression of endothelial genes such as Flk-1, Kit, Pdgfra and Tek was also increased with increased immunoreactivity against the gene products (fig. 3g).
Gene_expression (Expression) of Tek
12) Confidence 0.45 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0.23 Pain Relevance 0
Within 60 hours after plating on matrigel, the proportion of E-RoSH2.1 cells that expressed Tie-2 and Flk-1, the key receptors in the regulation of embryonic vascular development[27] was dramatically increased from <1% of undifferentiated E-RoSH2.1 cells to 61.5% and 40.25%, respectively (fig. 3f).
Gene_expression (expressed) of Tie-2
13) Confidence 0.45 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0 Pain Relevance 0
l of msTie2 retroviral particles, and 2.3 ?
Gene_expression (particles) of msTie2
14) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2830023 Disease Relevance 0.19 Pain Relevance 0
l of vehicle retroviral particles; msFlk-1/msTie2, 3.5 ?
Gene_expression (/) of msTie2
15) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2830023 Disease Relevance 0.12 Pain Relevance 0.09
l of vehicle retroviral particles; msFlk-1/msTie2, 3.5 ?
Gene_expression (3.5) of msTie2
16) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2830023 Disease Relevance 0.12 Pain Relevance 0.09
l of mEndo retroviral particles; msFlk-1/msTie2/mEndo, 2.3 ?
Gene_expression (2.3) of msTie2
17) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2830023 Disease Relevance 0.14 Pain Relevance 0
l of mEndo retroviral particles; msTie2/mEndo, 3.5 ?
Gene_expression (3.5) of msTie2
18) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2830023 Disease Relevance 0.13 Pain Relevance 0.05
l of mEndo retroviral particles; msFlk-1/msTie2/mEndo, 2.3 ?
Gene_expression (/) of msTie2
19) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2830023 Disease Relevance 0.14 Pain Relevance 0
l of msTie2 retroviral particles; msFlk-1/mEndo, 3.5 ?
Gene_expression (particles) of msTie2
20) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2830023 Disease Relevance 0.13 Pain Relevance 0.09

General Comments

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