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Context Info
Confidence 0.18
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.68
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CD58) plasma membrane (CD58)
Anatomy Link Frequency
T-cell 2
CD58 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 76.96 Quite High
cytokine 27 75.92 Quite High
tolerance 19 66.56 Quite High
chemokine 1 65.04 Quite High
palliative 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fowlpox 19 100.00 Very High Very High Very High
Renal Cancer 5 98.34 Very High Very High Very High
Cancer 203 97.74 Very High Very High Very High
Pox Virus Infection 30 97.28 Very High Very High Very High
Pancreatic Cancer 25 91.04 High High
Colon Cancer 3 87.92 High High
INFLAMMATION 5 76.96 Quite High
Death 3 76.84 Quite High
Disease 11 68.48 Quite High
Targeted Disruption 68 68.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human EC express CD40, CD58 (LFA-3), CD134 (OX40) ligand and ICOS ligand, which can contribute to T cell activation in vitro [21-23].
Gene_expression (express) of CD58 in T cell
1) Confidence 0.18 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 0 Pain Relevance 0.10
Similarly, treatment of renal cell carcinoma cells with subtoxic concentrations of adriamycin has been shown to upregulate the expression of ICAM-1 and LFA-3, as well as to enhance T-cell mediated killing, Fas-mediated, and TRAIL-mediated killing of tumor cells [86].
Gene_expression (expression) of LFA-3 in T-cell associated with cancer and renal cancer
2) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 0.93 Pain Relevance 0.08
The vaccination regimen consisted of vaccinia virus expressing tumor antigens carcinoembryonic antigen (CEA) and mucin-1 (MUC-1) with three costimulatory molecules B7.1, ICAM-1 and LFA-3 (TRICOM) (PANVAC-V) and fowlpox virus expressing the same antigens and costimulatory molecules (PANVAC-F).
Gene_expression (expressing) of LFA-3 associated with pox virus infection, cancer and fowlpox
3) Confidence 0.02 Published 2007 Journal J Transl Med Section Abstract Doc Link PMC2217514 Disease Relevance 0.75 Pain Relevance 0

General Comments

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