INT17612

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Context Info
Confidence 0.78
First Reported 1981
Last Reported 2011
Negated 16
Speculated 14
Reported most in Body
Documents 676
Total Number 690
Disease Relevance 580.61
Pain Relevance 119.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP) extracellular region (CRP)
Anatomy Link Frequency
plasma 33
blood 29
erythrocyte 25
liver 20
white blood cell 18
CRP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 9464 100.00 Very High Very High Very High
cytokine 2527 100.00 Very High Very High Very High
Inflammatory marker 852 100.00 Very High Very High Very High
Serotonin 72 100.00 Very High Very High Very High
Osteoarthritis 433 99.84 Very High Very High Very High
dexamethasone 224 99.84 Very High Very High Very High
rheumatoid arthritis 3909 99.74 Very High Very High Very High
Angina 1288 99.68 Very High Very High Very High
metalloproteinase 482 99.64 Very High Very High Very High
methotrexate 917 99.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 10847 100.00 Very High Very High Very High
Disease 6773 100.00 Very High Very High Very High
Rheumatoid Arthritis 4346 100.00 Very High Very High Very High
Diabetes Mellitus 4184 100.00 Very High Very High Very High
Obesity 2850 100.00 Very High Very High Very High
Nicotine Addiction 2384 100.00 Very High Very High Very High
Infection 1891 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 1414 100.00 Very High Very High Very High
Metabolic Syndrome 800 100.00 Very High Very High Very High
Pathologic Dilatation 750 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although C-reactive protein (CRP) as a serum marker is highly predictive for cardiovascular events, the intimal expression of CRP in clinically relevant coronary lesions is unknown, in particular in acute coronary syndromes (ACS).
Gene_expression (expression) of CRP associated with acute coronary syndrome
1) Confidence 0.78 Published 2002 Journal Z Kardiol Section Abstract Doc Link 12442194 Disease Relevance 0.98 Pain Relevance 0.20
In 40 of 90 lesions (44%), immunoreaction specific for CRP was observed demonstrating a mean CRP expression of 1.7%.
Gene_expression (expression) of CRP
2) Confidence 0.78 Published 2002 Journal Z Kardiol Section Abstract Doc Link 12442194 Disease Relevance 1.38 Pain Relevance 0.35
However, few studies have comprehensively examined six common single-nucleotide polymorphisms (SNPs) in the CRP gene, haplotypes, and plasma CRP levels with risk of coronary heart disease (CHD).


Gene_expression (levels) of CRP gene in heart associated with coronary artery disease
3) Confidence 0.77 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2148071 Disease Relevance 0.60 Pain Relevance 0.05
However, few studies have comprehensively examined six common single-nucleotide polymorphisms (SNPs) in the CRP gene, haplotypes, and plasma CRP levels with risk of coronary heart disease (CHD).


Gene_expression (levels) of CRP in heart associated with coronary artery disease
4) Confidence 0.77 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2148071 Disease Relevance 0.60 Pain Relevance 0.05
Oral hypoglycemic medications such as metformin and rosiglitazone, singly or as combined treatment resulted in lower CRP levels in subjects with T2D [16,17].
Gene_expression (levels) of CRP associated with diabetes mellitus
5) Confidence 0.77 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872322 Disease Relevance 1.38 Pain Relevance 0.41
On the other hand, local CRP synthesis and secretion by smooth muscle cells, including those of the human coronary artery, have been suggested to play an important role as well [22].
Gene_expression (synthesis) of CRP in coronary artery
6) Confidence 0.77 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2975076 Disease Relevance 1.32 Pain Relevance 0.11
Results of CRP are expressed in mg/l.
Gene_expression (expressed) of CRP
7) Confidence 0.76 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC115848 Disease Relevance 0.11 Pain Relevance 0
We suggest that the epithelial expression of CRP in autografts is characteristic of this model.
Gene_expression (expression) of CRP
8) Confidence 0.76 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 0.49 Pain Relevance 0.09
CRP expression has previously been observed also in endothelial cells [7] and smooth muscle-like cells [9, 10].
Gene_expression (expression) of CRP in endothelial cells
9) Confidence 0.76 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 0.46 Pain Relevance 0.10
C-reactive protein (CRP) is an acute-phase protein that is predominantly synthesized by hepatocytes in response to inflammation, infection, and tissue damage [3, 4].
Gene_expression (synthesized) of CRP in hepatocytes associated with inflammation and infection
10) Confidence 0.76 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 1.28 Pain Relevance 0.21
Our study found CRP expression in early obliterative plugs, but not in the mature, scar-like lesions, in which the existence of ?
Gene_expression (expression) of CRP in plugs associated with cicatrix
11) Confidence 0.76 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 0.97 Pain Relevance 0.22
However, our study does not support the use of CRP measurement in the lavation fluid as an early marker of OB, because local CRP is also expressed in human lungs in other inflammatory conditions in response to inflammatory stimuli [24, 34].
Gene_expression (expressed) of CRP in lungs associated with inflammation, respiratory syncytial virus and inflammatory stimuli
12) Confidence 0.76 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 0.73 Pain Relevance 0.10
In autografts, mural CRP production was turned off.
Gene_expression (production) of CRP
13) Confidence 0.76 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 0.45 Pain Relevance 0.17
C-reactive protein (CRP) is an acute-phase protein that is predominantly synthesized by hepatocytes in response to inflammation, infection, and tissue damage [3, 4].
Gene_expression (synthesized) of C-reactive protein in hepatocytes associated with inflammation and infection
14) Confidence 0.76 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 1.29 Pain Relevance 0.21
During the initial ischemic damage on follow-up day 2, 57% of the respiratory epithelial cells in the autografts and 48% in the allografts expressed CRP.
Gene_expression (expressed) of CRP in respiratory
15) Confidence 0.76 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 0.15 Pain Relevance 0
CRP expression was observed in all implants in the bronchial wall during initial ischemic damage, and then decreased in the autografts.
Gene_expression (expression) of CRP
16) Confidence 0.76 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 0.06 Pain Relevance 0
Extrahepatic synthesis of CRP was first described in human peripheral blood lymphocytes [5].
Gene_expression (synthesis) of CRP in lymphocytes
17) Confidence 0.76 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 1.28 Pain Relevance 0.21
on CRP expression.
Gene_expression (expression) of CRP
18) Confidence 0.76 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 0.95 Pain Relevance 0.30
The most intense CRP expression was observed during the accelerated inflammatory phase.
Gene_expression (expression) of CRP associated with inflammation
19) Confidence 0.76 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 1.20 Pain Relevance 0.20
Alveolar macrophages are known to express CRP [15].
Gene_expression (express) of CRP in Alveolar macrophages
20) Confidence 0.76 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 0.46 Pain Relevance 0.10

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