INT176133

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Context Info
Confidence 0.12
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.84
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (AKT1, BCL2) cytoplasm (AKT1, BCL2) cytosol (AKT1, BCL2)
cell differentiation (AKT1) nucleoplasm (AKT1) mitochondrion (BCL2)
AKT1 (Homo sapiens)
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 91.28 High High
cINOD 2 63.80 Quite High
Inflammation 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 48 100.00 Very High Very High Very High
Apoptosis 58 99.48 Very High Very High Very High
Aggression 2 80.36 Quite High
Cancer 33 79.76 Quite High
Endometrial Cancer 20 76.96 Quite High
Death 2 71.44 Quite High
Colon Cancer 2 68.00 Quite High
INFLAMMATION 4 63.24 Quite High
Malignant Neoplastic Disease 4 60.52 Quite High
Prostate Cancer 1 24.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Akt also blocks cytochrome C release from the mitochondria through the regulation of Bcl-2 [31] and regulates expression of cIAP-1 [32].
Akt Regulation (regulation) of Bcl-2
1) Confidence 0.12 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 1.08 Pain Relevance 0.17
Apoptosis-associated proteins Bax, Bcl-2, BAD and survivin have all been demonstrated to be involved in the chemoresistance of pancreatic cancer cells and be regulated by FAK or Akt [29-33].
Akt Regulation (regulated) of Bcl-2 associated with pancreatic cancer and apoptosis
2) Confidence 0.00 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.76 Pain Relevance 0

General Comments

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