INT176144

Context Info Confidence 0.36 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.29 Pain Relevance 0.04

lipid binding (PTEN) cell proliferation (PTEN) cytosol (PTEN) plasma membrane (PTEN) nucleus (PTEN) enzyme binding (PTEN)

PTEN (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 4 80.20 cINOD 2 5.00 Inflammation 2 5.00 Inflammatory response 1 5.00

Disease Link Frequency Relevance Heat Endometrial Cancer 20 94.44 Apoptosis 21 61.72 Cancer 16 5.00 INFLAMMATION 4 5.00 Aggression 2 5.00 Malignant Neoplastic Disease 2 5.00 Colon Cancer 2 5.00 Death 1 5.00 Prostate Cancer 1 5.00 Adhesions 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PTEN is a crucial phosphatase involved in the regulation of Akt phosphorylation: the presence of an active PTEN protein blocks Akt phosphorylation by the dephosphorylation of PI 3-K product, PIP3 [45].

Positive_regulation (active) of Phosphorylation (phosphorylation) of PTEN

1) Confidence 0.36 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.29 Pain Relevance 0.04

General Comments

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