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Context Info
Confidence 0.20
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.36
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CG) plasma membrane (PIK3CG) cytoplasm (PIK3CG)
Anatomy Link Frequency
macrophages 2
PIK3CG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 26 87.92 High High
antagonist 1 85.68 High High
chemokine 3 74.88 Quite High
cytokine 29 72.12 Quite High
tolerance 20 67.68 Quite High
Inflammatory stimuli 2 37.60 Quite Low
Kinase C 8 5.00 Very Low Very Low Very Low
bradykinin 4 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 21 97.40 Very High Very High Very High
Insulin Resistance 38 93.60 High High
INFLAMMATION 31 87.92 High High
Apoptosis 28 86.24 High High
Endometrial Cancer 20 76.36 Quite High
Metabolic Syndrome 25 70.80 Quite High
Diabetes Mellitus 203 68.16 Quite High
Impaired Glucose Tolerance 20 67.68 Quite High
Atherosclerosis 27 66.04 Quite High
Disorder Of Lipid Metabolism 6 64.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As hypothesized, the results demonstrate that PI 3-K inhibition results in the reduction I?
Positive_regulation (results) of Neg (inhibition) Gene_expression (inhibition) of PI 3-K
1) Confidence 0.20 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.38 Pain Relevance 0
Second, insulin is a vasodilator stimulating expression of eNOS through the phosphatidylinositol 3-kinase (PI3K) pathway (Zeng et al 2000).
Positive_regulation (stimulating) of Gene_expression (expression) of PI3K
2) Confidence 0.13 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 0.84 Pain Relevance 0.08
In addition, it accelerates cholesteryl ester accumulation in human monocyte-derived macrophages by increasing ACAT-1 expression via JAK2 and PI3K, thereby suppressing cholesterol efflux [29].
Positive_regulation (increasing) of Gene_expression (expression) of PI3K in macrophages
3) Confidence 0.11 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.14 Pain Relevance 0.14

General Comments

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